Rintatolimod

[Babylon5]

Chronic fatigue syndrome/ Myalgic encephalomyelitis (CFS/ME) is a poorly understood seriously debilitating disorder in which disabling fatigue is an universal symptom in combination with a variety of variable symptoms. The only drug in advanced clinical development is rintatolimod, a mismatched double stranded polymer of RNA (dsRNA). Rintatolimod is a restricted Toll-Like Receptor 3 (TLR3) agonist lacking activation of other primary cellular inducers of innate immunity (e.g.- cytosolic helicases). Rintatolimod also activates interferon induced proteins that require dsRNA for activity (e.g.- 2ʹ-5ʹ adenylate synthetase, protein kinase R). Rintatolimod has achieved statistically significant improvements in primary endpoints in Phase II and Phase III double-blind, randomized, placebo-controlled clinical trials with a generally well tolerated safety profile and supported by open-label trials in the United States and Europe. The chemistry, mechanism of action, clinical trial data, and current regulatory status of rintatolimod for CFS/ME including current evidence for aetiology of the syndrome are reviewed.

tandfonline.com/doi/abs/10....

[CheshireKatz]

Confused until doing a search and finding also known as Ampligen.

[Ian123 in reply to CheshireKatz]

Saved me looking.

[Dunnlyn]

Some of the drugs history phoenixrising.me/treating-c...

[ukmsmi4]

Some links regarding Ampligen/Rintatolimod

cfstreatmentguide.com/blog/...

meaction.net/2015/12/21/nih...

meactionuk.org.uk/treatment...