Any benefit from taking Mirapaxen and Madopar

[gp1943]

My husband has been on Mirapaxen and an increasing dose of Madopar for the last 2 years with no sign of any improvement in his mobility. The Madopar has just been increased again and he has become very agitated at the slightest thing and very shaky. Has anyone ever experienced any benefit from taking these drugs.

[ineke]

I have taken Miraxapan for 1 month, of no avail. Am not taking any

medication now! (PSP)

[dorothy-thompson]

dorothy-thompson

When my husband was first diagnosed wiith PSP he was given the the Parkinson's drug Sinemet for about 6 months. As there was no improvement his Neurologist took him of it and he does not take anything now. He is on the Davuentide trials but I can't see any progression with this either. It's all chemicals anyway so what's the point if they do no good!

[john_z]

My father was on madopar for a few weeks and we saw no help,instead he was getting worse with it.Now he is on Stalevo (it's Sinemet plus entacapone) and it offers him some help,especially in his mobility.Best wishes, John.

[Vitruvian]

Most PSP patients are first diagnosed as having Parkinson's disease, and it is often the failure to respond to the medicines which alerts the doctors to the diagnosis being incorrect. Most patients I have seen do not respond to levodopa (sinemet, madopar) though it's highly individual. Confusingly some patients, get no better on starting it, get worse on stopping it, then get better restarting it! You have to just try and see what happens. Some people get a bit sleepy or nauseous, but it will not cause any long term harm and is usually well tolerated. Good luck x

[Vitruvian]

Most PSP patients are first diagnosed as having Parkinson's disease, and it is often the failure to respond to the medicines which alerts the doctors to the diagnosis being incorrect. Most patients I have seen do not respond to levodopa (sinemet, madopar) though it's highly individual. Confusingly some patients, get no better on starting it, get worse on stopping it, then get better restarting it! You have to just try and see what happens. Some people get a bit sleepy or nauseous, but it will not cause any long term harm and is usually well tolerated. Good luck x

[jillannf6]

hi i was diaghnosed wih PSP and tried co careldopa for a few monthws

no benefit

then amantadine which seemed to stop my fallsl a littel btu them tjhey increased ihn number dramatically from SEPTtenber onwards

so i stopped the ajmantadie as well]

and now take nothign fo rteh PSP

lolc jilll

[PSPA_JillL]

It is really important that you discuss with whoever prescribed these tablets if the agitation and increased shakyness persist. Talk to your husbands neurologist or specialist or your Parkinsons or neuro nurse.

Some people have some benefit from the Levodopa drugs (Madopar , Sinemet) for some time. With any medicine it is important to consider if the benefits outweigh the disadvantages and you should discuss this with the prescriber.

[serendipity]

My mum has been on madopar for some years and is agitated and hallucinating they will not try another medication so i think side effects. worse than benefit