GABA Supplementation

[BluesHealer]

1) The cerebellum controls voluntary movements such as:

• walking.

• posture.

• balance.

• coordination.

• eye movements.

• speech.

2) Being "Progressive Supranuclear Palsy with Predominant Cerebellar Ataxia" a new identified variant of PSP, does anybody tried supplementation with GABA and what were the outcomes?

Kind regards,

Progressive Supranuclear Palsy with Predominant Cerebellar Ataxia

ncbi.nlm.nih.gov/pmc/articl...

[ChocolateFaceTeddy]

tell me more about this please

[ChocolateFaceTeddy]

sorry can you tell me more about this please

[BluesHealer in reply to ChocolateFaceTeddy]

Thank you so much for your interest.

Please find here a copy of the reply I sent to easterncedar some instants ago.

Best wishes

“In middle of February this year, PSP “offered” me a one-day lull:• The day before this event, my wife noticed that I was turning much better (freezing of gait in turns is my main claim concerning PSP).• On the second day I felt a full remission of PSP symptoms (no freezing of gait, no cervical pain, no unbalance). I felt myself as I was 20 years old. • Unfortunately, during the third day symptoms came back.Then I contacted two renamed neurologists and both were unable to find an explanation for this event.I decided to learn a little bit more about brain areas involved in pain AND in movement disorders.(I’m not a doctor, so it’s being difficult for me to investigate my case. Nevertheless, I’m the only person who knows better than any Doctor about my claims and symptoms).I found that the cerebellum is a brain area involved in1. PAIN (link.springer.com/article/1...“The functional role of the cerebellum in pain processing remains largely unclear. The most widely accepted idea is that cerebellar activity is related to the fine-tuning of the motor output when we experience pain, in order to protect it from further harm [8, 9].26/02/2018”and in2. MOVEMENT (simplypsychology.org/what-i...On one hand, since I suffer from severe pain in my cervical (... so close to the cerebellum) due to surgery and myelomalacia C4-C5, that is always preventing me, as a reflex, of moving the head freely (by sending alert signals to the cerebellum).Also the Westphal's sign in both knees and the neuropathic peripheral pain in my right side leg may be linked to the cerebellum.On the other hand my PSP, may be is a “mild” variant (PSP – PAGF or LD-PSP)onlinelibrary.wiley.com/doi...----What is GABA?There’s a lot of information in the web about the GABA neurotransmitter and the GABA supplement.For example: frontiersin.org/articles/10...When I was investigating what supplements I was taking by the occasion of this event I found that I had taken some days before the supplement PharmaGABA (and many others – this is making difficult for me to replicate the event).This is the reason why I’m looking forward experiences with this supplement (I ordered it yesterday and expect to try it again next week).Kind regards

[ShellTaylor]

Hi, I have had my Dad taking quicksilver liposomal GABA with L theanine to help with sleep for the past month, along w/ liposomal melatonin. It's tough to say if it's helped or not. I'll let you know if I determine anything further. His sleep varies so much and there are so many factors, it's always tough to tell what's working and whats not, plus he has sleep apnea and uses a cpap, but I certainly didn't notice a significant consistent difference. I will say we've tried all sleep meds possible (almost) and nothing helped without side effects that stopped us from taking it, so I'm trying all natural stuff now for sleep. I have heart PSP patients say extended release 10mg melatonin helped so you might try that and anything "nano" or liposomal form will be able to cross the blood brain barrier and get where you need it.

[BluesHealer in reply to ShellTaylor]

Many thanks for your kind reply. Concerning sleep issues, I suggest you to try Magnesium L-Threonate. It goes directly into the brain and also is a great help to control high blood pressure. I’m taking Magtein (a trade mark of this magnesium) since November last year and don’t need to take hidrochlorothiazide/losartan anymore. Best wishes

[ShellTaylor]

Great! thank you! Yes, I have him taking that already. How much do you take and when? I think I may not be giving him enough.

[BluesHealer in reply to ShellTaylor]

2 capsules before bed time and 1 cap in the morning. I realize that it may not work with some persons (it's the case of my wife). Thx

[ShellTaylor]

Thank you!!

[SandyMae42]

Haven't tried them yet, but I'm on a quest, and just ran across this: Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy ncbi.nlm.nih.gov/pmc/articl...

Also found this:

Neurological Improvement with Medical Cannabis in a Progressive Supranuclear Palsy Patient: A Case Report ncbi.nlm.nih.gov/pmc/articl...

[BluesHealer in reply to SandyMae42]

Thank you so much, SandyMae42, for your so kind support and useful info. I just restarted yesterday to take the Pharma Gaba by Thorne Research - let's wait and see...Best wishes

[ChocolateFaceTeddy]

I have found a online shop but which do you recommend please

[BluesHealer in reply to ChocolateFaceTeddy]

Hi, ChocolateFaceTeddy.

The one I (re-)started taking yesterday is PHARMA GABA 60 CAPS (THORNE RESEARCH).

Too soon to provide my impressions.

Best wishes

[ChocolateFaceTeddy in reply to BluesHealer]

thanks for the reply I’ll try them as anything to help x