I asked a question of Robin Riddle of CurePSP. Brain donation is presented as an option for PSP and CBD patients in the USA and they will facilitate it happening.
This was my question: A brain is donated, diagnosis is determined. Then what? How do they use the tissue to aide in finding a cure? Clearly it is too late for the donor.
Her answer: Truth is that a cure is far away. Closer is understanding the causes and figuring out a treatment.
Example - my dad's brain was one of 1K confirmed PSP brains that were used in a genetics study. Researchers found three new genes highly associated with PSP. (Finding not possible w/o brain donations.) Researchers are looking into all of these genes to try to understand the association with PSP. Can we modify these genes at all?
Same thing with CBD genetics. We discovered through brain donation many new genes highly associated with CBD. (BTW, Brain Support Network was responsible for a high percentage of those CBD brains studied.)
Researchers ONLY know there's something called Richardson's Syndrome in PSP from brain donations. We also know that those with PSP-RS have far more rapid brain atrophy than those with Alzheimer's. And we ONLY know there's tau in the PSP brain because of brain donation. Pharmaceuticals companies interested in a treatment for AD can far more effectively study experiemental medications in PSP-RS patients. Those clinical trials are only possible through discoveries made through brain donation. If a treatment is found for PSP, chances are high that the same treatment can be used for CBD.
Yes, clearly too late for the donor. But lots of brain donors, like my father, wanted to do something to fight back against the disease in hopes that others in the future would not have to be challenged by it.