i lowered my psa again down from 3.3 to 2.45

[iloweredmypsa]

Just pleased to report out that I have managed to lower my PSA for a third time in a row over the last 11 months, starting from when my prostate cancer was diagnosed last January. In January 2024 my PSA was 6.4, then in April to 4.7, July 3.3, and now November it's 2.45. I have only made diet changes and I now take some supplements. No surgery or radiation. Am I on to something real, or is this something others have done in the past? Thanks for any information.

[G6AS]

Sounds positive! What is your diet & supplement approach?

[iloweredmypsa in reply to G6AS]

I kept detailed notes, month to month. My kids organized my notes into this: iloweredmypsa.com

[conbio]

What is your status? MRI? Gleason?

[iloweredmypsa in reply to conbio]

Gleason 3-4. A second MRI to be scheduled shortly

[JVARA]

Hi, Yes Diet /lifestyle makes a massive differance. I also have the done the same, plus supplements among other things . Feel free to PM me if you want to discuss.

[Laguy01]

what is your diet?

[iloweredmypsa in reply to Laguy01]

I kept detailed notes, month to month. My daughters organized my notes into this: iloweredmypsa.com

[leach234]

You still have cancer no matter how you try to mask it. It’s not going away. What was your Gleason Score after your biopsy? You did have a biopsy didn’t you?

[iloweredmypsa in reply to leach234]

yes, a biopsy. 3-4 Gleason. So it's just a masking, not the actual death of cancer cells that is going on?

[Vynbal]

In addition to the comments I left on your post in the APC forum, let me say that some supplements can cause a false negative PSA reading. Trace elements of these supplements or their metabolites disrupt the chemical reactions used to identify and measure PSA levels.

[iloweredmypsa in reply to Vynbal]

Thank you for that information. any details you have would be appreciated.

[ironmanburg]

I don’t know if you’re on to something but I’d like to know what you’re doing.

[iloweredmypsa in reply to ironmanburg]

I kept detailed notes, month to month. My children created this out of my notes: iloweredmypsa.com

[Bryan46]

what supplements & diet changes

[Murk]

Your not trying to cure your PSA level, you're trying to cure PCa. IMO the only indicator that your regiment of vitamins & supplements is working is if you can measure the actual Cancer decline or progress. A baseline with following on measurements of the Cancer itself through regular biopsy test would show if its decreasing or increasing.

I am a total believer in taking vitamins & supplements and take my fair share. As we grow older our body's can benefit from adding these to our diets. I also believe that they can mask issues such as PCa.

Look at it this way... The best flag for PCa is PSA tests. What if these supplements are diluting the PSA tests results while the Cancer continues on its merry path...

[iloweredmypsa in reply to Murk]

Thanks for your thoughtful reply. There is is fair amount of University research that shows punicic acid, ursolic acid, carnosic acid can and do fight prostate cancer. Experiments show that. anyway, I will have an MRI soon and that will measure the current size of my tumor. If that is smaller, that may indicate that my actions could very well be reducing the amount of cancer in my body. I am cautiously optimistic.

[addicted2cycling in reply to Murk]

Murk wrote -- " ... What if these supplements are diluting the PSA tests results while the Cancer continues on its merry path... "

👍👍

[iloweredmypsa in reply to addicted2cycling]

My Harvard-trained urologist opines that once it's known that prostate cancer is present, that PSA test results correlate pretty tightly with prostate cancer cell volume, no matter where it exists in the body. Of course even my urologist admits he doesn't have the world cornered on brains. On the other hand, Murk's concept of 'diluting the PSA test results' is something I have yet to come across in the medical literature and I will be sure to bring up with my urologist the next time I see him. Thank you for your thoughtful reply.

[addicted2cycling in reply to iloweredmypsa]

iloweredmypsa wrote -- " ..... On the other hand, Murk's concept of 'diluting the PSA test results' is something I have yet to come across in the medical literature and I will be sure to bring up with my urologist the next time I see him.... "

A quick search showed the following and additional info available ----

* ..... According to current research, curcumin, the active compound in turmeric, may potentially lower PSA levels by inhibiting the androgen receptor, which is involved in prostate-specific antigen production, suggesting that it could potentially "mask" a slightly elevated PSA reading by reducing its level; however, more research is needed to definitively confirm this effect and its clinical implications, and it's crucial to always consult with a healthcare professional before relying on curcumin to alter PSA test results .... *

[lokibear0803 in reply to addicted2cycling]

Green tea extract has also been implicated in masking PSA, if I recall correctly.

I would think the tell is radiographic, not lab results. OP should get the MRI he mentions, if not a PSMA PET.

Speaking strictly for myself - using supplements against Gleason 3+4 is a flyswatter against Godzilla.

[iloweredmypsa in reply to addicted2cycling]

thank you so much. I will keep that in mind. And the MRI will be the final arbiter in determining whether my PSA reductions have been corresponding to reductions in the volume of cancer cells in my body.

[dhccpa in reply to addicted2cycling]

Your advice is wise, though I notice that the source you cited uses the dreaded words "may lower" and "more research is needed," just like articles recommending curcumin and other supps. Nevertheless, well worth noting the article's info.

[Thunderball1 in reply to addicted2cycling]

"Potentially"? 'Suggesting"? Any links to more definite information?

[lokibear0803 in reply to iloweredmypsa]

What I try to keep in mind when my MO tells me stuff is that these experts are speaking of dynamics across large populations, from controlled studies. They are not speaking directly about me.

My impression is that PSA test results generally, across large populations, correlate pretty tightly with prostate cancer cell activity vs volume, but I could have that wrong - regardless, that doesn't necessarily mean my PSA correlates tightly with my PC activity/volume/etc.

My volume, e.g., is quite low from PSMA PET results - I have one tiny spot near seminal vesicles. But my PSA doubling rate is quite aggressive. Everyone's situation is unique. My particular situation is an SPOP mutation, which has been seen to generate higher levels of PSA for a given volume.

The best way to determine volume is radiographic - get your MRI, and consider getting PSMA PET. One possibility is higher volume, but lower PSA activity. And, yes, another possibility is either efficacy or masking from your diet/supplements.

Get the scans.

[iloweredmypsa in reply to lokibear0803]

thanks for all that great information. this place amazes me. I get one free MRI a year, and now is the time. I have a dm into my urologist to schedule it now, and not wait for our appt dec 12. We will see what happens. thanks again.

[mac-12]

Chemo poisons all the cells and weakest(cancer) die first. Fasting weakens cells and the weakest die first, yes diet/suppliments. AS w/MRI/biopsies/PETscans w/contrast, to show shrinking of legion is gold standard to ultimatly kill all enemies on beachhead. Stay away from sugar, saturated fats. Stop everything that is feeding the enemy cells .I take Dutesteride/Fenbendazole/ and natural testosterone lowering, flaxseed/licorice root/, excercise, think Jack Lalanne routine of diet/excersise, we all pilgrims just passing thru

[BettyandBob]

Well, you might just be on to something. That’s pretty damn cool, IMO. However, talk with your docs to get their opinion. You’ll definitely have more information to work with following the MRI.

You have tapped an incredible resource here for soliciting opinions and help in addressing any questions you may have. One of our members is Tall Alan — I put a lot of stock into his feedback. I don’t think he has offered his opinion yet.

Wishing you the best in your journey.

[iloweredmypsa in reply to BettyandBob]

I may or may not be on to something. But I am inspired by the level of intellectualism as well as practical knowledge I am experience here. I think Tall Alan has had something to say. I will have to look back into the history if I can figure out how to do it.

[iloweredmypsa in reply to BettyandBob]

I found Tall Allen's remarks. Unfortunately he did not yet address my medical situation other than to dismiss out of hand as insufficient for his opinion.

[Lrv44221]

hi lower, i sent you a rather lengthy reply this morning but I must have accidentally sent it to someone else. Sorry I will write another to you later today. Basically I was agreeing with you and added a couple nutricuticals and a couple other suggestions

I’m so inept with technology so later i will send you a new one

💜💜💜💜

[BioPhile]

Thank you for sharing your journey, and documenting it month-by-month. Inspirational!

[iloweredmypsa in reply to BioPhile]

Thank you, you are too kind. What I am learning here from all you is incredible and is equally Inspirational. thanks again.

[leach234]

The smartest thing to do is to stop the supplements and see if your PSA level goes back up. That will tell you whether you’ve been masking your cancer or not.

[iloweredmypsa in reply to leach234]

thank you for that suggestion. I appreciate it. I am considering that after my next MRI.

[MrG68 in reply to iloweredmypsa]

No!

IMO the smart thing to do is continue what you are doing BUT also do the MRI. If you're doing an MRI you're not relying on the PSA test anyway. It's possible from your good results that you're benefitting in some way. Why stop that because people don't believe what you're doing has any credability? From what I can see, even if the PSA test is inaccurate from your protocol, where's the downside if you're doing the MRI? There is none - just possible upside. Unless someone can show some evidense of why your protocol would affect the MRI results.

Even if it was a placebo effect, so what? If it works, do you care? You know they include placebos for a reason, right? Why do people accept the scientific need for placebos, but reject other stuff?

Maybe you are benefitting, maybe you're not. Why change that?

Fingers crossed for you.

[iloweredmypsa in reply to MrG68]

Thanks for your post. I was just being honest. I was thinking about doing it. Since I am doing about 7 different research-based approaches to fighting PC, I would be nice to know which of them are the effective ones. The only way I have figured to do it is to stop some of them and see what the different is.

[dhccpa in reply to MrG68]

Excellent all around!

[WilsonPickett]

Bravo to you for investing in and doing all the work, and taking all the supplements. I do however concur with the advice given on this forum that we have no idea whether the supplements are reducing the growth of the cancer and thus lowering the PSA or masking the cancer by lowering the PSA. I would certainly continue with the MRI and maybe even consider a PET Scan if your insurance will pay for it. I personally would remain quite skeptical of your results.

[Thunderball1]

Metformin, atorvastatin, and mebendazole, are worth your researching into also as they are well-known repurposed drugs for PCa. I read your blog website account of your history. You are doing the right things and getting great results. The metabolic approach to starving cancer using natural supplements and old repurposed inexpensive drugs is becoming increasingly known. That's good for all patients and especially their families to know about in case PCa strikes others at an early stage. PCa has a strong familial aspect. I am also on active surveillance and taking all those supps too to try and stay that way. My PSA also dropped roughly two points (6 to 4). Just had MRI and a second biopsy; waiting biopsy results. But my brother had it worse so hopefully I can avoid that.