Intermittent ADT? Anyone tried this ... - Prostate Cancer N...

Prostate Cancer Network

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Intermittent ADT? Anyone tried this approach?

JPnSD profile image

I begin monthly Firmagon injections tomorrow. This drug can reduce testosterone 88% in 24 hrs.94% in 3 days...ànd some have reported their T will not recover for 2-3 months after an injection. After reading here about the idea that intermittent ADT may be as productive as full bore constant ADT (which may force malignant cell adaptation)....has anyone tried this approach?

12 Replies

Wait a minute - wasn't your situation that you are getting adjuvant ADT with radiation to try to cure you? If so intermittent is definitely not for you. Even if it did apply in your situation, beware of the large amount of misinformation on this site.

JPnSD profile image
JPnSD in reply to Tall_Allen

More of a question. I dread the effects of no testosterone. Was curious if I might have missed any recent developments. Start ADT today.

Tall_Allen profile image
Tall_Allen in reply to JPnSD

Nothing new on intermittent for adjuvant ADT with SRT. My point was that the misinformation you read on this site was about men with known distant metastases. Even for those people, we can not rule out that intermittent is inferior, and it has been proven that "full bore constant ADT" does NOT force "malignant cell adaptation" compared to intermittent.

I know it's not what you want to hear, but the opposite may be true - that stronger adjuvant ADT may be more effective than just Firmagon (or similar) alone for SRT.

Adding Xtandi to salvage radiation may be beneficial:

pubmed.ncbi.nlm.nih.gov/320...

And there are about a dozen clinical trials using advanced hormonals with SRT in the works.

BTW: I think you will get more relevant replies if you put some details of your current diagnosis and treatment history in your profile. It is not possible from your post here to figure out what your current situation is. I had to read through several of your old posts to figure out that you were talking about adjuvant ADT in the salvage situation.

I watched your IPSCG webinar link yesterday on YouTube, liked it very much. I plan on moving back to Phoenix and connect with Mayo clinic, and will see about intermittent ADT with hope I may be able to use proton radiotherapy at some point. I will also call the hotline provided by IPSCG to see if they have any suggestions. Thanks, it seems optimistic for you. Good luck.

6357axbz profile image
6357axbz in reply to jjpeabody

What link are you talking about? There is no link in this string.

JPnSD profile image
JPnSD in reply to 6357axbz

He referred to post I made on Saturday. Search IPCSG.org website. Their last presentation is on you tube - IMRT vs. Proton Beam.

Tall_Allen profile image
Tall_Allen in reply to JPnSD

There is no known advantage of proton over IMRT. A lot of hype about Bragg peaks from the proton folks though. Theoretical ideas don't necessarily result in clinical advantages. Here's what we know so far:

prostatecancer.news/2016/08...

JPnSD profile image
JPnSD in reply to Tall_Allen

You might be interested in this presentation by Dr Carl Rossi and Dr. John Einck of California Proton at Saturday's IPCSG.org meeting: m.youtube.com/watch?v=qeneBJaEGy4. (Start at minute 19 to bypass the membership housekeeping)

Tall_Allen profile image
Tall_Allen in reply to JPnSD

No, definitely not interested.- if he has something worth knowing, he will publish it in a peer-reviewed journal instead of a youtube video.

JPnSD profile image
JPnSD in reply to Tall_Allen

It was a presentation he participated in for the San Diego Informed Prostate Cancer Support Group as part of the annual presentation by the UCSD Team that deals with Prostate Cancer. Very kind of the Drs. at UCSD to do this and answer very specific questions from the attendees.

Tall_Allen profile image
Tall_Allen in reply to JPnSD

We're constantly getting requests from doctors to do presentations for our support groups in LA. We reject requests for our support groups (because peer-to-peer support takes up all our time) but sometimes they present to anyone interested in the Cancer Support Community offices.

6357axbz profile image
6357axbz in reply to JPnSD

TY

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