Spike in PSA

[WVtwinsmama]

My husband has been on Zytiga w/ prednisone for 14 months after tolerating only 3 cycles of chemo. His PSA has been below 1 for a year. This week it went from .44 in July to 2.59. It seems like a big spike with really no other physical symptoms. We retest in late Sept, but wondered if others have experienced a jump like this that was caused by something other than having run the course with Zytiga?

[Grumpyswife]

Similar to failing Xtandi, the docs mentioned having three consecutive PSAs showing a definitive rise and also prefer to cinfirm progression in a scan before discontinuation. Others swap the Prednisone for something else.

[Farmer-joe1]

Hi wvtwinsmama I had two doses of chemo and it nearly killed me so they put me on zolodex 3monthly injection with casudex my psa went down to .4 the it spiked again up to 17 so now I’m on Eligard 3monthly injection with enzalutimide 160 mg daily over 3months the psa has gone down to 7 and continues to fall hope this post helps . Ps I’m 65

[WVtwinsmama]

Thanks, I guess the good news is there are other options. We’ll see what the next test brings.

[Peterd110]

When did you switch to generic zytiga? ( if you have )

[WVtwinsmama in reply to Peterd110]

Have not.