Panadol and Prednisone interaction

[AussieKid]

I was interested to read PMRpro's comment within a recent post concerning how Panadol interacts with Pred during metabolism. I am trying to find that comment and would ask PMRpro for any further information and reference to more fully understand the process please. My background is PMR 10 yrs/GCA 6 yrs for past 10/6 and having had a number of orthopedic operations. rotator cuff repair 2022, full lumbar fusion 2023 and reverse shoulder replacement 2024. Pred dose 10mgs for a week with each procedure. (currently 3mgs). I found myself very sensitive to any of the opoid painkillers and directed to taking regular PanadolOsteo for a month or so and then intermittently following each procedure. During this time my Kidney function has declined dramatically GFR 70 down to currently 44. Upon reading your reply to that post I have stopped taking any Panadol or other pain medication other than the low dose aspirin. Thanks for any further insights about Panadol and Pred interaction.

Absolutely love this site, great information, great people and lots of empathy

[AussieKid]

Please ignore 10/6 - should have deleted it before posting.

[DorsetLady PMRGCAuk volunteer]

I can’t recall the comments, PMRpro replies to a lot of posts ..but she will explain again.

Can I suggest that if in future you see something that you think you might be useful to you, you save the post, or just the reply in it… quite easy-

3. SAVING POSTS OTHER MEMBERS HAVE WRITTEN

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To retrieve - tap Home - top left in banner, takes you to new screen which gives options - News Feed, Explore and Saved, tap "Saved" and hey presto there it is /they are.

You will also be advised of any new replies provided you have selected that option in your email notifications - see profile (avatar) top right of screen

When you receive email notification- there’s a See all my Saved Posts> link written in blue to access them

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Under each reply if you tap More V - you get a box - “Copy reply link” . Just tap that - and you should get message at top of your screen on this page which says “reply link copied “ green background. That then disappears - and hyperlink is saved.

Then save it where you like - into a Word document, into Notes - or maybe just email to yourself until you decide where you want to keep it. But you do need to paste it somewhere otherwise it just sits in the ether.

Once it’s pasted successfully, you’ll see the hyperlink in blue…

**these are from my post in the FAQs -

healthunlocked.com/pmrgcauk....

Under the heading -

NON MEDICAL QUESTIONS

FAQs- How To Use HealthUnlocked - Help Us To Help You 💻

[Mrsd12f in reply to DorsetLady]

That’s helpful info, DL.. Thanks.

[AussieKid in reply to DorsetLady]

Thank you so much, I’ll try and use the info asap.

[PMRpro Ambassador]

Can you direct me to the post concerned - subject or context even if you don't know the post itself? Because I'm having a total blank moment!!!

Normally there are no interactions listed for paracetamol and prednisolone.

[AussieKid in reply to PMRpro]

Hi PMRpro, thanks for responding so quickly. The post was within the last 2 weeks or so. You were commenting how Paracetemol is processed I think at the cellular level when a person is on cortisone. You made the comment when you worked in some pharmacy/pathology laboratory you would occasionally see something different and not readily explainable. You might make a recommendation to your senior that another blood sample be drawn and submitted to make sure the result was true. That Panadol was not always as free of problems as has been assumed.

I cannot recall the title of the original post.

Hope this helps.

[AussieKid in reply to PMRpro]

Hi PMRpro, thanks for responding so quickly. The post was within the last 2 weeks or so. You were commenting how Paracetemol is processed I think at the cellular level when a person is on cortisone. You made the comment when you worked in some pharmacy/pathology laboratory you would occasionally see something different and not readily explainable. You might make a recommendation to your senior that another blood sample be drawn and submitted to make sure the result was true. That Panadol was not always as free of problems as has been assumed.

I cannot recall the title of the original post.

Hope this helps.

[PMRpro Ambassador in reply to AussieKid]

I'm so sorry - I should have got back to you sooner. I have written dozens of replies in the last few weeks and although I have gone through a lot of them on my profile page, I don't have time to go through the process of calling each up to read in full - you are very welcome to do it yourself though!!

There is some evidence that paracetamol may encourage production of cortisol but I doubt that has any effect on tapering. It has been known by the medical community that paracetamol isn't a medication with no adverse effects for years - but some doctors seem to suggest it is perfectly safe.

This is a paper referring to that error

researchgate.net/publicatio...

[AussieKid in reply to PMRpro]

Thank you PMRpro. I quite understand how busy you must be on this site. Your knowledge is immensely important.