New insights into mysterious blood vessel disease temporal arteritis...medicalxpress.com/news/2023...
Found this on FB....: New insights into mysterious... - PMRGCAuk
Found this on FB....
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That second trigger is the reason that half of patients with GCA do not respond entirely to TCZ s the T-cell factor produces IL-9, TCZ works on IL-6 and that alone.
Not a bad historical article - more about the T-cell stuff would have been nice!
Thank-you
Is IL-6 the cytokine that is referred to as the first breakpoint?
My understanding is that it is the main culprit...buy for me, I don't know. because I have problems getting under 20 mg prednisone.
Not familiar with the term - what is it?
Breakpoint? It was my predhead recollection of 'checkpoint' in the article, eg 'They found a second immune checkpoint that is not working in GCA.' (CD155)
Hahahahaha!!!! Well done - like it
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Some interesting points - but I wish "they" would explain that -
a. a bulging temporal artery is not ALWAYS present, and
b. and even if it is affected, it does not cause sight loss- it's the ophthalmic artery deeper within within the brain that starves the optic nerve and affects sight.
I know - I didn't have an affected temporal artery [so no "obvious" sign] but I sure as heck had GCA and lost sight. .. and sure I wasn't, nor will continue to be the only one.
Thank you. That was very interesting
Interesting article. Food for thought. Thank you.
Probably not unreasonable to extrapolate these findings and speculate a similar process occurs in PMR although I am not aware of any evidence for irreversible vascular damage in PMR and complete remission does occur.
A step too far to speculate that the abnormal immune response may protect those who suffer from GCA/PMR from some cancers though!