So after 6 years on steroids Actemra finally enabled me to get down to 6.5. Started August 2017 once a week. No reaction. Inflammation immediately dropped. CRP and ESR almost none existent. Recently went to every Other week and blood markers still down no change. I am now going to wait a third week and check my blood and hope the inflammation has not gotten too bad. However the nasty thing is that I have no adrenal function as a result of the length of time and High doses of Prednisone. Got the results of a synacthen test Monday and adrenals not react at all. I am on 8.5 mg prednisone and seeing a new endocrinologist Monday. It’s really nasty having no adrenal function it affects everything. At first I thought it was the steroid reductions. When I realized my pressure went whacky and I was sweating and nausea and fatigue I realize this was different. So now I have to learn how to deal with not having adrenals. Heading back to Actemra.... my feeling is if you have the opportunity to take the drug you should. I never had an infection or any of the reactions that you can get from the drug. It only did good things for me and I took it for a short time just to get lower than 12.5 where I was relapsing time and time again. It is a gift horse for some of us And should be taken advantage of. For me steroids were and are a nightmare and have destroyed my body.