I get anxious and excitable when I am on it. I am a 65 year old male. I also retain water and have increased appetite. When taking Prednizone, the PMR pain is less but the side effects are just not worth it. Haven't taken Prednizone in over a week, BP is normal and I am much more relaxed. I am going to the gym regularly and lifting low amounts of weight with 12 reps. It is painful but I would rather live in pain than die of a heart attack or stroke. I am also doing Cardio; walking, Elipitical, Cycling, etc. My left shoulder is the worst. Thinking of asking my rheumatologist about giving me a cortisone shot.