I am having increasing pain in my right shoulder, buttocks, thighs. I was taken off Actemra for the GCA in November due to severe GI problems, although we are not sure if they are related. What I have been thinking is Restless Leg Syndrome, could the severe pain with the restless legs be PMR relapse. My ESR and CRP have returned to normal levels while I have been on Actemra. I am really confused what all this muscle/joint pain means. Any comments or suggestions is appreciated. Thank you, and Happy New Year to all of you!