My partner has PMR, was on prednisone for about 11 mo. when she had a bowel perforation. Her surgeon (who performed a colostomy) believes the prednisone was the cause of it. It seems her only alternative is methotrexate. She hates the idea of going on it as it seems poison to her. Her rheumatologist says that she can't just treat the pain of PMR (like with ibuprofen or medical marijuana for example) but must treat the underlying disease with a drug like methotrexate, otherwise, the PMR will get worse. Is that true? Any information would be greatly appreciated.