I have read in the past that some of you take your prednisone in the evening. I have always been hesitant to do that because prednisone is known is known to keep one awake. Also, I sometimes feel like the pain reduction wears off mid evening when taken in a.m. - so wonder how long it would be effective the next day if taken the evening before. Lately I have questioned my routine because I seem to have more energy in the evenings. Am wondering if I should give pm dosage a try. Am I making any sense here? Those who have tried it seem to like it. Any advice?