I have been on the Leflunomide for a year now and for 4months on an increased dose, and I am having a nasty flare which started on 21st Dec. At the same time, my blood test results showed up some renal issues and I have already had increased blood pressure, both of which are side effects from the Lef. I spoke to Rheumy today and he agreed that the Lef. isn't working and I will come off it. He mentioned trying Mycophenolate once the Lef. is out of my system and commented that my PMR is "Refractory" (meaning stubborn) and that I am quite resistant to the Pred. Both of these are bad news! The only other option he can see is to apply for funding ,which I may not get, for Toxilizumab .
I think he is worried that I am needing too much Pred. I keep flaring every time that I get below 11mgs and I have lost count of how many flares I have had in the last 2 years. I don't seem to have made any progress, despite doing very careful reductions and have had PMR for nearly 3 years now.
Any information about Mycophenolate would be gratefully received and any other words of hope or comfort while I am feeling a bit hopeless about ever making progress with either the drugs or with the PMR reducing or dying away.