Could somebody advise me please ? Hi its trish 29 here and I have just started taking Leflunomide 20 mg this week after 10 years of PMR and many failed attempts to reduce steroids.. In this 10 years I have taken Methotrexate .. Azathiaprine ./ Salphasalazine / Amitriptyline but something usually sets off a flare and I have to start again .. I asked my consultant for this medication as I read up that Prof Gaspatu has a high success rate with it with his patients particularly the long time steroid users like me . My pain level is already slightly easier but I wondered when others taking this medication can advise when the best time is to take it as I take it with a meal about 5pm and find that I still toss and turn at night and I am waking in the morning very drugged up as though I am away with the faries and this takes until lunchtime or after I have an afternoon nap to clear, plus of course I get steroid euphoria .. Through flare-ups this year I have been back up to 18.05mg steroid but at the moment I am on 15mg but I need to drop another half mg in a few weeks .. I have a meeting with my GP next Thursday for a B/p check and to discuss this New Course of steroid reduction approved by my caring Rheumatologist. Any advice will be most welcome. trish29
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