AMA

[7443jec]

What is considered a high AMA. I was told that mine was 1 over 640. Is this high?

[gwillistexas]

My Mitochondrial M2 AB was 128.0. In my lab it should be less than 20.0. Is that what you’re referring to?

[luxe66 in reply to gwillistexas]

Mine was the same, the number shows the presence of AMA in 1:640 dilution, doesnt mean the amounts of AMA, just shows, that they can detect it even in such large dillution

Doesnt probably say anything about severity)

[gwillistexas in reply to luxe66]

My ANA titer was 1:640. What was your pattern? Mine was speckled.

[gwillistexas in reply to luxe66]

Your first post was about AMA. Do you have a result on that one as well? They are separate tests.

[luxe66 in reply to gwillistexas]

At the time of testing ANA was negative

And then i had biopsy as well

[iagra]

AMA is regarded as a flag, a marker for PBC, and possibly other auto-immune disorders, not a test, like ALP. The value of it is not as important, as the fact that the value is higher than the upper limit of the normal range for AMA.

"A high AMA or AMA-M2 level (titer) in the blood indicates that the most likely cause of symptoms and/or liver damage is PBC. The level of AMA is not related to the severity of PBC symptoms or to a person's prognosis. "

Cheers!

[7443jec in reply to iagra]

Thank you, I have recently been diagnosed with PBC and am trying to judge how severe it is. I am seeI got the consultant soon so hopefully will get some answers. X

[iagra in reply to 7443jec]

Of course! Best to talk to your doctor. But, don't worry too much about AMA, it is simply a marker. Good luck!

[MDE9]

It sounds like this might be an ANA result rather than AMA. ANA (Antinuclear antibodies) is a measure of autoimmunity and measured as a titer like this, and “1:640” is a common elevated finding in PBC (There’s often then an ANA “pattern” type that’s also included, and some patterns are more typically associated with PBC, like “centromere” or “speckled.”) 1:160, 1:320, 1:640, 1:1280, or 1:2560 are the possible abnormal titers, which is why it sounds like this is what you’re talking about.

[7443jec in reply to MDE9]

No it’s definitely AMA, antimitochondrial antibodies. X

[Sona_akb]

Yes it’s considered high. As I know, titers more than 1:20 are considered positive

[Ellyne]

AMA's come in titers as well and ANA.

[7443jec]

Thanks.

[claygi]

My last numbers were 1:1280. Doctor said it’s irrelevant in relation to disease progression.

[7443jec]

Mine was 1/640, but as you say this may be irrelevant. I’m having a fibroscan in October apparently this is instead of a biopsy. I’m having an endoscopy in July. What about you? Xx