I was diagnosed in 2010 after elevated labs and AMA. Biopsy from 2010 states:
Morphologic features consistant with an early stage of primary biliary cirrhosis (stage 1 of possible 4). Presence of periductal granulomas and small duct epithelial damage. Reticulin stain reveals clumping of reticulin fibers around necrotic liver cells. All other stains normal.
I have been on Urso this whole time. My labs have been normal except for one outlier. I had another biopsy (my choice) to check for progression. My new biopsy states:
Focal nonspecific inflammation in the portal areas, without increase in periportal fibrous connective tissue, there are no diagnostic histologic features of cirrhosis or hepatitis, all stains normal (including Reticulin stain). The submitted biopsy does not have any diagnostic features of primary biliary cirrhosis.
I am still AMA positive.
While this is great news for me it leaves me with so many questions. Anyone else ever have a followup biopsy that revealed a reversal of damage?