Hello everyone! This is addressed to the ladies, which most of us are (not all though! Waving at our men PBC friends!) In March I had to undergo emergency surgery to remove my 1 remaining ovary, as it had become twisted and full of blood. I was in horrible pain and was given a lot of pain medicine. It really threw my liver into a tailspin and caused increased liver inflammation. It eventually passed, but now I seem to be having that pain more, coupled with a great deal of back pain. My question is, did any of you in regular menopause or the surgically induced kind notice a spike in your PBC symptoms? I also had my thyroid removed last year, so I am dealing with regulation of thyroid hormone, PBC and now this. I have rejected HRT because of the liver, but I don't know if I can continue with this. I was just having the hot flashes, which aren't that bad, but now I am having a lot of joint and muscle pain. I am concerned because when I was in the hospital, they did a CT of my abdomen to visualize the ovary and saw a small (very small) spot on my liver that they said was "too small to characterize" and said likely a cyst. So in the back of my mind I am worried that this was a small carcinoma that has grown. But then my brain says, you are dealing with a drop in estrogen as well. Any suggestions?