I was diagnosed with PBC 3 years ago. I don't always take my urso because I feel the side effect of weight gain is too scary for me. I had a gastric sleeve done 2 years ago and lost 80 lbs. Im terrified I will gain it back. I started rapidly gaining after taking the urso, so I read up on it on the internet and found out it was a side effect of the medication. I told my doctor I would not take it anymore and he told me to try just taking it once a day and see how that goes. My liver enzyme levels are 4 times higher than normal still and now he is doing a new liver test on me tomorrow. Im terrified i sacrificed my liver for my weight. Is anyone else out there gaining weight from this drug?