It is just about a year since the severity of my "itch" became almost intolerable. I have seen the GP and have been prescribed Ranatidine which helps my reflux (was on omeprazole) and quietened the itch, this was at my request following a post from another contributor and not because of GP suggestion. Unfortunately it did not get on top of it completely so two days ago whilst in the Supermarket I just thought I would speak to the Pharmacist about the antihistamines that can be taken 3-4 times a day instead of the one a day I have taken for many years now. I asked her to confirm that it had similar properties and was cautioned about the drowsiness effect. Dare I say I am on day 3 of Pollenase 4mg tablets (chlorphenamine maleate) and have found the itching very quietly in the background rather than that itch which requires the nails to be dug deep into the flesh. So far I do not appear to have suffered with the drowsiness but then I rarely have the brick wall of PBC fatigue. Also because of another contributor I regularly use doublebase cream and with this combination I have had three very tolerable days!
I post this in case it is of any help.