A couple of months ago I posted that I had been diagnosed with PBC in 1999 via having elevated AMAs, but have since been in the care of my GP . During that time I have had no treatment whatsoever , despite steadily worsening LFTs, with considerably raised Alk Phos and GGT and symptoms of intense itching and chronic fatigue. Many thanks to all who replied. Following your advice I went to see my GP and persuaded him to refer me to a consultant . The consultant was horrified that I have been left to languish for 15 years with no treatment whatsoever. The Consultant was dismayed that my GP had been telling me for more than 10 years that my symptoms of itching and fatigue could be nothing to do with PBC because my bilirubin was not elevated much. So at long last I will be getting Urso. I have had a liver scan showing my liver is enlarged. Am going for further more detailed scans. I hope that the 10 years of non-treatment whilst being symptomatic has not harmed me significantly. If there is anyone else left in the hands of a GP , do ask for a referral to a specialist!