Hi, I am 45 and diagnosed with PBC ten years ago! Last summer I was signed off my work as I couldn't cope any longer - I had tried every medication possible for the itch, Naltrexone had worked for a year but suddenly stopped. I was referred to the Liver Transplant Unit and it was suggested I try Plasma Exchange Treatment. Very intense to begin with as it's 5days, then down a day every week until I was going once a week, now after seven months I go every two weeks and I have my life back, I still take 10mls Naltrexone at night but my itch has gone!! I am quite small so my treatment only takes two hours, I can now drive to and from the hospital but have to come home for a sleep afterwards as it does make me tired and a bit nauseous. I just wanted to share this with all the sufferers of itchy skin, it has completely changed my life.