Vitamin B6 injections?

[qwertystar]

I found out I’m deficient in B6. I was taking p5p supplements but stopped.

Has anyone tried B6 injections if so, which type of B6 would you recommend?

[wedgewood]

I haven’t the need to have B6 injections , but if I did , I would buy from the companies that I know are very reliable for b12 ampoules . Obtainable at our usual German online pharmacies of apohealth.de and versandapo.de

Pascoe manufacture a packet of 10 ampoules of B6 . Ref. 02180182 25mg x 2ml

Pascoe manufacture 100 ampoules of B6 Ref 02180213. 25mg x 2ml

Hevert manufacture the same .

[qwertystar in reply to wedgewood]

I’ve seen so many posts on fb saying how bad b6 injections are.

I think I’ll inject b6 once a week. I’m clueless with the protocol

[wedgewood in reply to qwertystar]

I would take great care with B6 injections. What have you heard about them on fb? They can probably be overdosed .

.

[Lurcher-lady in reply to wedgewood]

They can be overdosed. I had a multivitamin which I later found after reading the ingredients had over 700% rda I developed tingling hands and feet, which stopped when I stopped taking them.

[KTW029 in reply to Lurcher-lady]

Yes same thing happened to me too. I am very wary of B6 now. I know we need some but not too much.

[Baklava22 in reply to qwertystar]

Too much B6 can cause peripheral neuropathy. Apparently B6 is often added to health supplements and people aren’t aware. I think it was an Australian news story where the woman couldn’t walk and they diagnosed B6 toxicity. Do your research first and everything in moderation. It’s such a minefield of what’s good and what’s not 😝

[Sea-blue]

Hi Quertystar. I would be very careful with B6 supplementations as it can easily become toxic in higher levels . You should be surpervised by your medical team and have regular blood tests to see how high your B6 is during treatment .

[Oneash]

From what I learned last night, you need to balance B6 with zinc, so it functions properly.More beef and eggs to get both naturally.

[qwertystar in reply to Oneash]

Thank you! I’ve upped my beef intake and egg yolk. That’s all I ever eat lol

[Technoid]

How did you find out you were deficient in B6?

[qwertystar in reply to Technoid]

I had blood test in the nhs ms clinic. I just let them test all my bloods and not take the ms meds. They just want to keep giving me medication which I never take!)

They said I’m deficient in pyridoxine and not to worry. I’m able to read bloods as I use to work for the nhs and I’m aware of how awful they are.

I haven’t got ms, my private doctors have tested me and said it’s not ms.

[Technoid in reply to qwertystar]

Interesting. There are some conditions that can cause B6 deficiency, a deficiency from diet alone is rare and if present, other nutrients would likely be low also. Do they have any idea the cause or a plan to investigate? If they don't find out why, it could happen again after corrective supplementation finishes.

[helvella]

Do you have a reason to want injections rather than oral B6?

After all, I'm sure the majority on this forum would choose oral B12 over injections but inability to absorb makes that non-feasible.

I'm not ware of any specific B6 absorption issue that would force the use of injections except in somewhat extreme cases. But that could just be my ignorance.

[qwertystar in reply to helvella]

I just assumed it would be better absorbed.

[helvella in reply to qwertystar]

I tend to use the word "absorb" to refer to the taking from mouth/gut into the bloodstream.

Obviously, something directly injected into the bloodstream achieves 100%.

But unless you know for sure that the oral form has a significantly lower absorption, the difference could be close to nothing. I simply do not know the percentage absorption of oral B6. Nor if it varies by vitamer. If it is high, then you might well be able to compensate for that by taking a slightly higher dose. I think it would have to be relatively low to justify an injection - or the need be pretty urgent - or both.

[EiCa]

I was going to write about B6 this week so this post is timely. I have had blood work that shows I am deficient. Also I have high homocysteine and one of the protocols is B12, B6 and folate. So I have been experimenting with P-5-P dosing as I am very sensitive. I have considered injections but I am reacting pretty strongly to oral, so I guess I am absorbing it. Why did you stop the P5P? I was taking 20 mg. and was not feeling much. I upped it to about 40 mg. (once a week) and got pretty severe burning feet, which goes away in 1-2 days and then comes back. So I think the oral is working. My problem is I started having pretty severe gut pain right around when I started supplementing with this. I can actually put up with the burning feet (I ice them) but the GI pain makes me not eat for a day. I know B6 can have many toxic effects and erring on the side of caution is better but B6 is sorely needed for proper methylation and many other bodily functions so a deficiency really needs to be addressed. If I were to get injections, it would most likely be B6 and not P-5-P. I have not seen those offered anywhere.

[JesusMercy60 in reply to EiCa]

hello all, so I read on a section on our forum that p5p can be taken in higher doses and not cause any harm, I hope thats true. my new multi that I got has too much mg like 75 m so I take 1/4 of the tablet. what do you think about the p5p and the post on it not being toxic.

[Technoid in reply to JesusMercy60]

There is no separate tolerable upper limit for the P5P form of B6. There is no expert consensus on whether B6 in the P5P form would be nontoxic in doses exceeding the B6 upper limit (which unfortunately also varies by country).

[EiCa in reply to JesusMercy60]

Because I am trying to figure out the dose that is right for me, I have read a lot about P-5-P toxicity. There are frequent warnings about toxicity and neuro symptoms from taking too much. The upper limit (I assume of daily ingestion) is usually 50 mg. For me, I get burning feet with that much. I don't know if burning feet indicates that it is toxic, but it is obvioiusly some sort of warning signal. I would not refer to it as "reversing out," but who knows? Trial and error is the only answer here.

[Technoid in reply to EiCa]

Neither the US, Europe nor the UK have set separate upper limits for any specific B6 form, such as P5P.

The US upper limit for B6 is 100mg

ref: ods.od.nih.gov/factsheets/V...

In Europe the EFSA have set an upper limit of 12mg

ref: efsa.europa.eu/en/efsajourn...

The UK has the most conservative B6 upper limit, of 10mg.

ref: nhs.uk/conditions/vitamins-...

Do you have a reference for a 50mg upper limit? Other countries may vary.

The problem with a trial and error approach to B6 when taking doses above the upper limit is that high doses of B6 have led to neurological issues. If you were to interpret neurological symptoms from excess B6 as reversing out, you might be making a mistake if they are not actually "reversing out" symptoms but symptoms of B6 toxicity.

If one was to persist with high dose B6 supplementation regardless, in the hope that the "reversing out" would eventually disappear, that misinterpretation could result in permanent neurological damage, if the B6 megadoses continue for long enough.

Trial and error is fine when a mistake is easily spotted and corrected. But in this case its possible to make a foreseeable mistake whose outcome is not reversible and the result is not a learning experience but a lifetime of regret.

[EiCa in reply to Technoid]

I agree Technoid. I am not really buying the "reversing out" explanation in my case of burning feet. (I was "heading off" any ideas that that was my symptoms are, really) That is why I am being so careful but I really need to supplement. I have read dozens and dozens of articles that suggest 50 mg. as the upper limit (and I should have said that even those recommendations say not every day, or for an extended period of time) Everything I have learned is to be careful and go slow so I am doing just that...trying to find a non-toxic dose which seems to be pretty low for me, somewhere between 20 mg and 50 mg/ week. I am now going to go really low and try the smallest dose I can measure. I do know that I need B6. I am at the bottom of the range and have a lot of B6 deficiency symptoms. I wrote this before but I had burning feet before I started taking B6, just not as bad, but 3 times I have taken a higher dose I had really bad burning feet. I am in the US and I just read multiple times that 50 mg. could be a decent upper limit but everyone is different so proceed with caution, which I am, and which is why I wrote my post as this is tricky navigating this. I especially need the B6 as a cofactor with B12 and B9 because of my high homocysteine. I eat meat, but don't absorb enough I guess. I don't know how to figure this out without trial and error, but I am being exceedingly cautious which is why I wrote. I was encouraging the original poster to go slow and take B6 seriously. I also have noted that since adding B6 to my folate and B12 injection, I am tolerating those better. I definitely need to supplement all three...per blood tests and symptoms.

[SuperhydroIM]

I inject Pascoe B6 25mg 2ml. I take it when I feel like it. The injection makes me feel very very good. You would have to inject doses like 300mg daily to get into toxicity from what I know.

[EiCa in reply to SuperhydroIM]

Would you mind expanding on that comment that it makes you feel very very good. In what ways? Did you always respond favorably to it?

[SuperhydroIM in reply to EiCa]

I am aware I can only talk for myself and everyone is different, especially our methylation status. Through a few years I noticed I must be careful with B9 - folate. However I have injections of B9, I learned to mostly stay away from it. A naturopath once analysed my body and energy and told me exactly the one thing I knew and two new things, one was lead overload, second was B6 deficiency, the third one was low on digestion/peptides, but this I already knew. When I started supplementing with B6 injections, my left leg numbness which I had in certain conditions went away. I injected the way I felt about it, and I do not encourage anyone doing the same, this is just my personal approach that works for me, I learned to go by the gut feeling. B6 I injected a few times a week at peak. Now I have it once or twice a month. I love to combine it with my 1500mcg hydroxocobalamin 1ml dose in a 3ml dose. I use a 5ml injection for this. I have big muscles on my legs and 3ml is not the upper limit for me. I am aware not everyone would be comfortable with such volume or do this. B6 makes me feel more alive than B12. Yes, B12 corrected my biggest problems in the long run, but it never gave me such a boost as B6. My body comes alive with B6. I also do take a B complex without folate but not always. If that helps somehow, I do also inject B1, B2, B9 and B12 in methyl, adeno and hydro form. I use Pascoe homepathic line a lot too. I know this is not something many of you will agree, but my life is back. I am 48 now and feel in best shape of my life and still getting better. I belive in orthomolecular approach. I megadose on B1(thiaminhydrocloride) and on B3(instant release Niacin form). I eat a carnivore diet mainly and am in ketosis almost every day, I do not eat breakfast. 10 years of vegetarian diet brought me to my knees, my body could not handle it. I am aware some people do ok and thrive on vegan or vegetarian, it is just not for me. I eat beef, eggs, butter, raw honey before sleep, never have it for breakfast, having sugar carbs for breakfast will ruin your blood glucose for the whole day. Sounds like a crazy men talking, I can workout for two times a day and have energy for long walks every day, years ago I struggled and gasped for air many times just sitting and getting tired of thinking. Sorry for this long story, just felt like it. I feel like it is always the best to paint a whole picture, so you can understand the aspect of the subject, and still the painting is always cut at the borders

[qwertystar in reply to SuperhydroIM]

Wow that’s amazing! Did you ever check your b6 levels?

B12 also doesnt give me a boost. I also inject b1, b2, b9, methyl, adeno and hydro by Pascoe. I’m deficient in b6, b2 and low in b1, but I’m struggling with eating b6 foods.