Hypothesis XIIII

[WIZARD6787]

That a higher or lower concentration of B12 might be more bioavailable and therefore more effective and appropriate for treatment.

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The level of competence of those studying B12 is not sufficient enough to test this hypothesis or even consider it as a possibility.

B12 might be more unstable at a higher concentration and Bigmedical would not make as much profit.

Bigmedical has decided 1mg/ml is good enough for you.

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Trial of last 24 days ; 1.5mg methylcobalamin, 1.5mg adenosylcobalamin, 1mg hydroxocobalamin. SC injection 5 times a day including setting an alarm to inject at night. 50 mg B6 in the form of P-5-P or pain from peripheral neuropathy returns.

14 days ago I kept the same amounts as above and changed the concentration. I had kept the concentration of 1mg/1ml as a way to be able to compare and contrast results of different trials. I track administration by mg not jabs. I changed the concentration of methylcobalamin to 3 mg/ml and the adenosylcobalamin to 2mg/ml.

The effectiveness was increased, obvious and immediate, within 12 hours. The effect was so dramatic that I could not keep up my 5 times a day routine and injected 3 times a day, 4 times a day and 5 times a day to regulate healing. As close to finding what works as I hope to experience. I seem to be on track now and will inject 4 to 5 times a day based on healing intensity. It is not practicable to sleep and rest as much as is needed with improved regimen and therefore improved healing.

I experienced some symptoms getting worse as I healed more quickly. Nothing like all symptoms being worse when under supplementing injecting 1.5 mg every other day or even when under supplementing injecting 1 mg three times a day with 4mg SC adenosylcobalamin. (The later regime eliminated symptoms commonly associated with B12 deficiency after 6 months.)

It was a nerve racking 14 days and I had to trust my methodology when it seemed like I was making everything worse.

April 08 I took a three day trip to view the total eclipse and that was meaningful to me. The day of the eclipse I drove 5 hours in heavy traffic including a traffic jam for a couple of hours when driving the single lane highway in the Francina Notch in the White Mountains in NH. I spent three hours viewing the eclipse and drove back to my hotel.

The trip back to my hotel took 9 hours to drive 140 miles much of it bumper to bumper on dirt roads. Pretty much I was up a 6:00 am and was active until 1:00 am the next day. It was fun and much more enjoyable than it would have been before I discovered that an increase in concentration resulted in more healing.

I nor anyone else has a reason that the increase in concentration resulted in more effective healing. It does not contradict the general principles of biochemistry or even chemistry. Testing has not been done regarding frequency or concentration of B12 injections. Other than Chandy no testing has been done with regards to improved treatment and I find it likely there will be no testing of improved treatment until a biomarker in a petri dish is discovered which I find unlikely as B12 is utilized in 50 known process in the human body and 6 genetic abnormalities have been discovered. Pretty much all autoimmune diseases do not lead themselves to simple testing leading to better treatment. The promise of individualized treatment would accept the 1mg EOD concept.

It is also possible that a lower concentration would be more effective. Chemistry is like that. I am not working with more is better. I am running trials. It is a reality that I started with 1mg every day which is appropriate for some, if not, sucks to be you.

So this discovery is problematic as it requires a whole other line of inquiry which means more trials. First thing is I have to solve the logistics of being able to vary the concentrations. Good news is I can likely experience continued improvement as I design trials. With my experience and current knowledge I have an idea of what to expect with any change be it positive or negative and it does not take months to determine of the change was positive or negative as it did when under supplementing. Recovery time is at most days now other than this last improvement.

I have been in this part of NH I was traveling throughout my life starting at age 0. The pain I experienced as a child was not all in my head. Sad it took 67 years to discover this fact. It is not I have to grieve that loss as it is all I ever knew it is more of a celebrate the now. It is not that I did not lead a very meaningful life just it was harder than it needed to be. B12 was not synthesized until I was a sophomore in high school. The research for successful treatment for the most part stalled at that time. Actually in the USA the treatment was more robust and therefore more effective in 1972. The treatment in the USA has gradually been reduced by applied scientists with no regards for patients experience with the focus being on hematology not neurological symptoms.

One of the most pronounced changes that I experience is that I no longer have intense muscle cramps if I do not shower once or twice a day. Ironically I no longer have the relief from a nice hot shower as my body does not need it. This severe cramping started at age 8.

So even with the eustress of my travels it is easier to be me than 14 days ago. Rational process rules! Following with regards to B12 not so much. Much easier when there is someone to follow which is much of the time.

[GoneWithTheWind1972]

It’s so wonderful to hear of your improvement in healing. Your research is fascinating. I am curious though, if the excess B12 is excreted within a few hours and the body benefits the B12 replenishment, why aren’t we offered/recommended more than once per day?? Especially with neuropathy present, in order to heal quicker?? Yes, big pharma could not profit or benefit from vitamins and not much research has been conducted so, I assume we will never know. I’m also considering B12 twice per day now, as I can’t source Adenosylcobalamin for SC injections so, will consider my methylcobalamin twice daily. I have managed to source Adenosylcobalamin for transdermal use, have been doing this for a few weeks now.

Thank you for your thorough self research, you have given me much food for thought.

[WIZARD6787 in reply to GoneWithTheWind1972]

Hey GoneWithTheWind1972

Thank you for your reply it is appreciated.

I do not contend that the B12 I inject is excreted in a few hours. That is unknown. I do contend that when I inject B12 it not as effective after 4 to 5 hours.

The discoveries from my work to date is the length of time of a B12 injection is effective. The amount of 1mg EOD is not scientifically supported. And for me hydroxocobalamin and cyanocobalamin were at least at one time equivalent for me. And most recently a higher concentration of B12 is much more effective at the same amount.

I am still working on what form, combination of forms , amounts and frequency are the most effective.

I only post here about administration of B12 for the most part. Supplementation is only a small part of my work regarding B12.

Applying the discoveries I have made have led to healing. Exploration and discovery is like that.

>>why aren’t we offered/recommended more than once per day?? Especially with neuropathy present, in order to heal quicker??

It is the failure of those licenced by the state. Those that write the guidelines and those that fail to follow the ineffective guidelines.

It in my case is not healing quicker rather at a level that is not distressful to to point of reducing my life span.

I conclude that big pharma is being scapegoated in this case. They are not licenced by the state to write the guidelines or in control the application of those guidelines. There is no scientific reason to believe that a different compound is needed. There are currently 4 forms of B12 not tested at all by those that write the guidelines or the non-profit 'research' companies.

Big pharma created the vaccine for COVID and the treatment. Those the wrote the guidelines for number of days the treatment should be continued did not follow the science and reduced the length of time the treatment was administered causing much unnecessary suffering. Big pharma is the hero with Covid and they even made it simple enough even physicians could comprehend how to diagnose and treat.

I look to the people that do profit from the current treatment of B12 not those that do not.

[Wwwdot]

Hi Wiz

So glad you enjoyed the eclipse! What a journey on many levels.

You are obviously in top form as your post is comprehensive and packed full of info. I need far more time to read and digest.

Been under the weather lately and my B12 residence time has noticeably shortened so had to reduce time between jabs and add an extra one in to my daily routine.

Thank you for sharing your knowledge and research.

🤗🤗🤗

[WIZARD6787 in reply to Wwwdot]

Thank you!

I have turned a corner it seems and this is getting easier. Perhaps on the cusp of self treating is just something I do and not so all consuming. Very glad I did the work I needed to do. Which others had done it or at least not pretended that had done the work I could and needed to do.

I have an operational draft of how to successfully treat having been B12 deficient. I doubt I will ever have a final draft as my body is healing and that changes what is needed.

In summary I discovered that the same amount of B12 at a higher concentration is more effective. Noone has looked at that as far as I know.