New Study : Vitamin B12 boosts cellular reprogramming

[Technoid]

" In the context of aging, although most diets across the world contain sufficient amounts of B12, older individuals often present poor B12 absorption and, therefore, partial deficiency of B12. Our work suggests that this could in part contribute to the lower tissue repair capacity of older people, and thereby to the higher levels of inflammation (inflammaging)”, continues Serrano."

"this study not only increases our understanding of the molecular and metabolic mechanisms of cellular reprogramming, but also closely links vitamin B12 levels with epigenetic regulation; it thus highlights vitamin B12 supplementation as a potential therapeutic strategy for enhancing cell plasticity and tissue repair."

nature.com/articles/s43587-...

[JGBH]

Unfortunately behind a paywall… so can’t see the article.

[Technoid in reply to JGBH]

Sorry about that, hopefully it should turn up in a site like sci-hub soon.

[JGBH in reply to Technoid]

Let’s hope so. …

[Technoid in reply to JGBH]

Try this link

rdcu.be/dtbWs

[JGBH in reply to Technoid]

It works! Thank you. So important information regarding the role B12 plays in cell repairs and inflammation. So one could deduce people who have autoimmune diseases (RA, Sjogren’s, Lupus, hypothyroidism etc.) could reduce inflammation with the help of B12. It also mentions people who have surgery would benefit of supplements of B12 to speed their recovery. Yet, most doctors do not seem to know, nor care. B12 supplements are cheap to prescribe… so no gains for Big Pharma…

[Marz]

My friends Dad has just passed away at 97. His notes indicated Low Thyroid and for the very first time he had been recently prescribed Levothyroxine/T4 !

For the last few years he has been in and out of hospital being patched up after falls. A symptom of both low B12 and Thyroid. No doubt costing 1.000's when inexpensive meds could be preventative....

Sadly so many with low thyroid suffer low B12 - and still adequate testing remains elusive - without a fight.

When will the correct testing become routine enabling inexpensive treatments help the elderly have a better QOL

I am 77 - taking T3 - self prescribed and self-prescribed B12 injections weekly ! So far - so good.... 🥰

[Mixteca in reply to Marz]

I'd be interested to see your thyroid test results. My T3 was a tad low and I'll be retesting my levels again very soon.

[Marz in reply to Mixteca]

When taking T3 only results are of little meaning. TSH is suppressed - FT4 low in range - and hopefully T3 in range. Not had a test since late 2019....

[Mixteca in reply to Marz]

Yes, they are, so I was thinking of the initial tests you had that convinced you to self treat - if it worked that way of course.

[Marz in reply to Mixteca]

I had read about taking T3 with T4 on TUK and spoke with my German/Greek GP. She agreed my conversion could be better and prescribed T3 which I bought in the local pharmacy for a couple of euro. This was over 10 years ago. I then dropped the T4 and slowly increased the T3.

[MorningMist in reply to Marz]

What was your reason for weekly b12 injections? Was it to complement your thyroid treatment?

[Marz in reply to MorningMist]

I had extensive gut surgery for ileo-caecal TB some 50 years ago - so no Terminal Ileum. I learnt about the importance of B12 from TUK forum and began reading. B12 is metabolised in the Ileum and transported back to the liver for recycling - simply put 🌻

[MorningMist in reply to Marz]

The need for b12 injections after your surgery is clear. I was struck that they were self prescribed and not advised by a doctor.

[Marz in reply to MorningMist]

I had 6 monthly check ups for Crohns for years when Docs had plenty of opportunity to test and treat for B12D ! If they knew that is !

I joined TUK in 2011 - you can click onto my username and read my Bio. That is when I began to read, learn and understand more. From reading posts/replies here it is clear many Docs are lacking in B12 knowledge - sadly.

[charks]

Can't read the article. Can you copy and paste it?

[Technoid in reply to charks]

linked one that works now, above ^

[WiscGuy]

Another article by different authors but a similar title was published recently enough that you might not yet have seen it. Though the title is similar, I don't know how similar the content might be. This is the link:

nature.com/articles/s42255-...