"All of the three highlighted B vitamins may create the necessary environmental conditions for successful nerve regeneration, each of which via individual modes of action (concluded in Figure 1). Vitamin B1 essentially facilitates the energy production needed for the process and acts as a site-directed antioxidant, while vitamin B6 is vital for neurotransmitter synthesis and for inhibiting the release of neurotoxic glutamate [29, 32, 40]. Vitamin B12, on the other hand, largely promotes nerve cell survival and is strongly and directly involved in remyelination and the maintenance of myelin sheaths [41, 42, 46, 47, 56]. However, to elucidate molecular mechanisms, prove nerve-regenerating functions, and investigate neuroprotection, further experimental in vitro and in vivo studies with the individual B vitamins and the combination are needed.
Very useful, thank you!I know I need money knowledge on B1 and B6 but don't get the spare time these days (because I'm reasonably well and active) to stop and look them up.
I like this bit: ‘If the amount of B12 does not cover the demand (which is significantly increased during nerve regeneration and myelin formation), not only can important proteins (e.g. the myelin basic protein) not be generated but also homocysteine accumulates and promotes oxidative stress and damage’.
Sorry for the duplication. I don't have an online computer. Phones are useful for phone things, but are not that good for word processing or document management. So I don't have a useful record even of the articles I have posted links to.
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