Link between PA and Liver function

[Ronty86]

Hey everyone, does anyone know of there is a link between PA and liver. I’ve been recently diagnosis with PA following B12 level at 128 pg/ml and positive anti-parietal test (treatment starting next week). I also had anti-smooth muscle (liver) antibodies come back as positive and my doctor states they are both linked to PA so no further action required.

[FlipperTD]

Scientist, not medic.

PA is an auto-immune condition, where your body produces antibodies against 'self'. The 'best' autoantibody test for PA diagnosis is against Intrinsic Factor, which is produced by parietal cells, but it's only positive in about half of the cases of PA. Parietal cell antibodies are often found in PA, but they're not specific as they're found in other conditions as well, so it's less useful as a diagnostic test in this instance. Listen to your doctor, but it may be worth asking about the IFAb test as well. The important thing here is your low B12 level has been spotted and you're going to be treated.

Good luck!

[Sleepybunny]

Hi,

Sorry, I don't know much about about liver and PA but will look into it if I have time.

A few links that might be of interest...

Link about "What to do next" if B12 deficiency suspected or recently diagnosed.

b12deficiency.info/what-to-...

PAS (Pernicious Anaemia Society)

Based in Wales, UK.

pernicious-anaemia-society....

There is a helpline number that PAS members can ring.

PAS website has useful leaflets

pernicious-anaemia-society....

Unhappy with Treatment (UK info)?

Letters to GPs about B12 deficiency

b12deficiency.info/b12-writ...

UK B12 documents

BSH Cobalamin and Folate Guidelines

b-s-h.org.uk/guidelines/gui...

Summary of above document

pernicious-anaemia-society....

BNF Hydroxocobalamin

bnf.nice.org.uk/drug/hydrox...

NICE CKS B12 deficiency and folate deficiency

cks.nice.org.uk/topics/anae...

Each CCG/Health board in UK is likely to have its own local guidelines on management of B12 deficiency. I suggest you track down the local guidelines on B12 deficiency for your CCG/Health board and compare them with BNF, BSH and NICE CKS links.

Some local guidelines in UK are unhelpful. See blog post below about a UK area that has a poor reputation on this forum for how B12 deficiency is managed.

b12deficiency.info/blog/202...

Two useful B12 books

"What You Need to Know About Pernicious Anaemia and B12 Deficiency" by Martyn Hooper

Martyn Hooper is the chair of PAS (Pernicious Anaemia Society).

BNF treatment info in book is out of date. See BNF hydroxocobalamin link in this reply.

"Could it Be B12?: An Epidemic of Misdiagnoses" by Sally Pacholok and JJ. Stuart (USA authors)

Very comprehensive with lots of case studies.

B12 article from Mayo Clinic in US (aimed at researchers and health professionals)

ncbi.nlm.nih.gov/pmc/articl...

Table 1 in above article is about frequent misconceptions about B12 deficiency that health professionals may have.

Links below are to forum threads where I left detailed replies with lots of B12 info which you may find useful eg causes and symptoms of B12 deficiency, more UK B12 documents, more B12 books, B12 websites, B12 articles and a few hints on dealing with unhelpful GPs.

healthunlocked.com/pasoc/po...

healthunlocked.com/pasoc/po...

healthunlocked.com/pasoc/po...

I am not medically trained.

I hope you get the treatment you need.