IF Test and supplementation - Pernicious Anaemi...

Pernicious Anaemia Society

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IF Test and supplementation

User2020-1 profile image
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Hi all,

I’ve often questioned myself about my PA diagnosis because it’s been playing on my mind that I had an injection 1 month, and daily sublinguals before the day I had my blood test that showed +ve antibodies…

Knowing there’s recommendations to not supplement before the test - does anyone know if taking supplements/injections beforehand leads to false positives OR usually false negatives?

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User2020-1
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Gambit62 profile image
Gambit62Administrator

The injection a month before won't be an issue ie won't have affected the result.I really don't know if the oral dose would be enough to influence the result - suspect it wouldn't. If it did have an influence then it would be to increase the chance of a false positive but I'm not sure by how much.

PA is the most likely B12 absorption problem and the main interpretation problem with the IFAB test is false negatives (40-60%).

FlipperTD should be able to give you a more precise answer.

User2020-1 profile image
User2020-1 in reply to Gambit62

Thanks Gambit62 - I was hoping it would increase likelihood of false negative rather than positive as my diagnosis is 100% accurate as PA then….

Thanks

User2020-1 profile image
User2020-1 in reply to User2020-1

In a nutshell, I had a +ve diagnosis despite the supplements and injections so glad if it decreases likelihood of positive result - I’m 100% PA basically

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