I found a Haematologist consultant's powerpoint presentation about the "diagnosis and management of vitamin B12 disorders" which, in discussing pernicious anaemia, made reference to an association with blood group A.
No more detail than that, it being mainly bulletpoint prompts, but this interested me as it is something I'd never heard before.
Made me wonder about statistics : how many of you, like me, are in this blood group, and whether that is significantly more than the general population ?
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Cherylclaire
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Thanks, fbirder - I'll give it a try.I can only find a reference in a paper from 1956 - which can't have prompted inclusion by a haematology consultant for a major hospital's training session on B12. There must be more somewhere , surely ?
Interesting. We've had a similar discussion about general autoimmunity prevalence by blood group on one of the Sjogren's forums, (and Covid risk) but with no conclusion.
Peter D'Adamo has a paragraph in Eat Right For Your Type where he states that PA is higher in Type As. He suggests that PA and B12D is most common in Type As, followed by ABs, because they have lower levels of intrinsic factor and produce less stomach acid, hence absorbing less B12 from food and benefitting from injections. (He says that Os and Bs have higher stomach acid and sufficient levels of intrinsic factor. But as other autoimmune conditions seem to hit type Os and other things will affect your intrinsic factor/parietal cells (Coeliac for example) this presumably is not an absolute rule.) It isn't a terribly satisfactory paragraph of explanation, and the book is outdated, but an interesting idea. I found this bit on his website, dadamo.com/txt/index.pl?3006, from The Lancet (1966).
I'm an O with B12D and other autoimmune conditions. Sadly I don't know blood groups for PA family members.
I wouldn't pay too much attention to it. I'm group O and have PA with both IF and PC antibodies. My mum is group A and her b12 is fine, dad is group O and has low b12 but not low enough for his GP to agree to treatment.
I agree! I was intrigued when first lent the book, because the suggested 'good' foods for type O were so similar to what experimentation, and testing, had showed, but it doesn't seem to hold up that well. He makes some interesting points on susceptibility to childhood illness. Sorry about your dad, I hope GP will change opinion. Is oral supplementation any use to him. Got my dad started on Better You Boost and it has made a vast difference. Cheers
Thanks for the recommendation but I’ve only just persuaded him to add solgar gentle iron to his many medications, the iron tablets he was prescribed by his GP didn’t agree with him. He now has 3 of those 7 day boxes that I’ve labelled and I fill with tablets for the morning, tablets for bedtime and now capsules for 4pm with orange juice. Besides his 3-4 times a day insulin and blood testing and other meds as needed my parents can’t cope with anymore.
Dad is blind, mum has dementia and my sister and I are unable to go in every day as we both have health problems ourselves. Things are rather difficult at the moment! We’re trying to sit tight and cope for a few months hoping that the Covid immunisation program makes looking into a care plan of some sort easier.
Hi showgem that’s harsh for you I’m sorry to hear about your family.Better You do a complete b daily oral spray this would bypass his stomach and not cause those issues,we use it ourselves also the vit d3/k2 by better you is excellent you can buy reasonable on amazon ,have a look at the better you oral spray ,products they do a few.best of luck x
I'm so sorry to hear that. The Solgar iron is good and I have used Spatone sachets too which you could maybe try if the Solgar don't suit. My mum had dementia too (although mainly it was an unidentified homocysteine issue), and it was after she died that Dad's B12 got so low. I hope things settle and improve for you all and wish you all the best.
With a blood test, but too late, after she had developed Myelodysplasia . I have (theoretical - genetic, and actual) problems with the folate cycle so use a small amount of methylfolate along with B12 which has helped me considerably . Best wishes x
I'm rhesus B negative and so were both of my parents - very rare and lucky for me! My Dad had PA and my Mum probably has at least folate deficiency problems - she certainly has the symptoms! There are a lot of malabsorption/metabolism/heart problems in most of my family on my Dad's side (we're discovering as we're getting older!) so there's definitely a genetic link somewhere!
If Dad and I are B- there's a good chance others in my family are too.
I'm intrigued now and will ask them at some point!
Well, thanks to everyone who replied, shared, joined in with this post. I'm now thinking that the best way of finding out the source of this information is to ask the haematologist consultant herself- after all, she wouldn't have put an unsubstantiated comment into a powerpoint lecture, surely.
I'll let you know if I get an answer.
Hidden - I also gave blood when young, and remember bring surprised about the cups of tea, biscuits and/or crisps offered and the advice about taking it easy. Funny -It always made me feel so much better and more energetic after I'd given blood; I told the nurses that I maybe had too much to start with ! I used to practically skip the three miles home afterwards.
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