B12 anxiety.

[Shipra33]

Is it normal to feel unexpectedly anxious and have sleep disturbances after your intial b12 Injection?

Isn't b12 supposed to make things better

[fbirder]

It’s not at all uncommon. Stick with it.

[Shipra33 in reply to fbirder]

Thank you!

[Nackapan]

It does happen. Nerves seem to get stirred up. Not pleasant. Try and go with it . If will pass soon hopefully.

[pvanderaa]

To give you some understanding of what is happening with the B12D and then how B12 works.

Before you started injections, your cells in your body had built up a backlog of metabolism in the methionine loop due to the deficiency. Some of these chemicals and molecules were doing their normal jobs in excess and eroding myelin off your nerves and decreasing the efficiency of the connections between nerves.

Your body had compensated to keep things “normal” by creating additional connections. Your brain had adjusted to the lower levels of B12.

You most likely had neurological damage of the brain and subsequently psychological symptoms of the mind started. Depression, brain fog, short term memory loss.

When you get B12, the backlog of metabolism takes off like a dam breaking and floods your blood stream with byproducts as well as chemicals, molecules, amino acids, hormones, etc needed for life. The methionine loop starts DNA methylation up again and things start to get back to normal with energy production and cell replication.

You get additional symptoms, which are counterintuitive because they are similar to your existing symptoms so things in general seem to get worse.

The circuits in the brain are now overcompensating and so you can feel supercharged. In my case, agression was one of these psychological symptoms from the overcompensating. Over thinking, anxiety, crazy dreams put on what I describe as a roller coaster ride. These highs and lows continue until you’ve filled in the low points by getting enough B12.

Start a logbook of all your symptoms before and after your jab. Try to assess a daily severity score to each one. The ones that appear after the jab are good indications that B12 is working. Once you know what your pattern is, you get some control back and can start to relax.

I get a huge soft poo about 6 hours after the jab. This, I now expect, so I don’t get anxious wondering what it was that I ate to cause it.

Anxiety, if you can measure a severity level for your anxiety, is just another symptom to be logged. Stress is another. It consumes B12 and uses it up faster.

I’m currently on weekly cyano injections. But I split them in half and take half on Mondays and the rest on Thursdays . I spread my folic acid throughout the day and don’t take it all in one go.

Are you supplementing with a daily multivitamin and folic acid?

Using the logbook I also identified new intolerance to gluten and dairy, which probably had been there all along but I had built up a tolerance to which my body was overcompensating after I got on B12 injection.

Good luck in your hunt for your smooth ride.

[fbirder in reply to pvanderaa]

There is no such thing as a ‘methionine loop’.

Supplementing with B12 does not “flood your blood stream with byproducts as well as chemicals, molecules, amino acids, hormones, etc.

[Shipra33 in reply to pvanderaa]

Makes sense pretty much. My anxiety, brain fog everything is worse than before the shot. I don't know how long till I start feeling normal again.

The shot I take includes some folic acid too. Currently not on multivitmains but will start soon.

Also, just an anxious thought but it would be great if addressed. Do you think some of my symptoms could be irreversible? I've had them for like 3 months and oral supplementing didn't help. Started with shots just two days ago. So, could it be possible that I waited too long and now there's no going back?

I had a level of 300ish.

[pvanderaa in reply to Shipra33]

Neurological damage is sometimes irreversible but the body tries to build new pathways.

Nerve repair is triggered by usage. Gentle range of motion exercises for long and muscular nerves. Brain exercises - Daily short term memory tests to measure -games like mahjong and solitaire to exercise thought. Passive watching doesn’t cut it.

Anxiety, at least for me, comes and goes. The way I monitor progress is to compare the peak to the same peak the previous cycle , (i.e. the same day after the jab). Day to day comparison is useless because of the roller coaster ride. The logbook becomes your memory as well. If you just remember to get into the habit of writing everything in it when it occurs, not writing a summary when you think you will have more time.

[Nackapan]

I hope not. Healing can take some time and if can depend on how long you were low for.

Just keep up your 12 treatment .

Early days

[anonymous1279]

It's not normal. But I did face similar issues...extreme anxiety 24-48 hours after injection.

Here is what I did:

1. If it's a B-complex injection, stick to B12, folic acid and niacinamide.

2. Eating potassium rich foods.

Hope this helps

[Shipra33 in reply to anonymous1279]

Yeah my anxiety started after about 24 hours too.

I hope it's better after the next shot

[SouthSounder]

I've had mild RLS most of my adult life. The condition got slightly worse w/injections, and has eased a bit again after decreasing them post-loading, though I can't be sure the B12's the cause.