Unusually high dose B12 supplement

[helvella]

Someone has just mentioned the product below. (As with most things people are trying to flog, easy to find by searching - and I do not want to put a link and there be any possibility of someone clicking and buying from it.)

Your opinions, please?

B-12 Extreme™- 35 mg , 30 Lozenges by ProHealth

#PH314 - Vitamin B12 Complex Lozenge - by ProHealth

4.5 star rating

60 Reviews

The Most Potent Vitamin B-12 on Earth

For mental acuity, energy, liver support, and detoxification

Provides all four forms of B-12

Includes the only two biologically active forms of B-12

Description

ProHealth's founder, Rich Carson, set out to develop the most potent B-12 supplement on the market - and that he did! B-12 Extreme contains the world's most potent single dose of all four forms of B-12 on the market, including the only two biologically active forms in humans - methylcobalamin and dibencozide. Low blood levels of vitamin B-12 are frequently associated with fatigue and malaise. Hydroxocobalamin and methylcobalamin have also recently gained attention from leading CFS and FM researchers and doctors.

MENTAL ACUITY - Methylcobalamin 12,500 mcg

Methylcobalamin, perhaps the most important and potent of the essential cobalamins, plays a vital part in cell growth. Particularly important for your central nervous system, it helps promote healthy homocysteine levels and helps increase the brain's focus and clarity, and the spinal cord's function.

ENERGY - Dibencozide 12,500 mcg

Dibencozide- also known as Adensylcobalamin- metabolizes essential fatty acids to produce more energy. As a biologically active form of B-12, this B-12 lozenge reacts with cells to provide muscles and nerves with bursts of energy.

LIVER SUPPORT - Cyanocobalamin 7,500 mcg

Cyanocobalamin, the most common of the cobalamins, becomes active in your liver, creating enzymes to help the body with blood formation, cell reproduction, iron utilization, and tissue synthesis, while aiding the digestion and absorption of foods.

DETOXIFICATION - Hydroxocobalamin 2,500 mcg

Hydroxocobalamin, one of the three essential cobalamins that make up the vitamin B-12 complex, helps support overall detoxification. Contained in ProHealth's sublingual B12 supplement, it also assists with methylation and energy production.

[Gambit62 Administrator]

sounds like a product that is more marketing hype than a good idea

The dose of B12 is enormous and I wouldn't recommend it to anyone who doesn't have a B12 absorption problem. It might possibly be of use to a very very small minority of people who have specific genetic variants affecting the metabolism of B12.

Personally I wouldn't touch it with a barge pole.

[fbirder]

A waste of money.

The amount of B12 that can be absorbed in one go is limited to about 13 mcg. So taking a 35000 mcg tablet means that about 34,987 mcg are going straight through you and down the toilet.

Their claims for the different types of B12 having different effects is total shullbit. b12science.com/B12Science/T...

If this were in the UK I'd be sending another letter off to the Advertising Standards Authority.

As a clue - any advert that mentions 'detoxification' is talking rubbish.

[helvella in reply to fbirder]

Another clue, in my experience, is using the name dibencozide instead of adenosylcobalamin.

(Very rarely is the name dibencozide used in PubMed.)

[Gambit62 Administrator in reply to helvella]

however, dibencozide is the name frequently used for supplements. Personally I wouldn't read too much into the use of the term.

[Hidden]

When i worked in a care home (psychiatric) there was a man who apparently drank a whole bottle of concentrated orange juice, with the inevitable bright yellow result.

[pvanderaa]

Your body pees away the excess and all four forms are converted into each other in the body as needed. Total hype.

I bet you can get a pretty good headache from it if you are deficient.

[Hidden]

medindia.net/doctors/drug_i...

"• The side-effects of adenosylcobalamin may include the following:

• General: Fever, low blood potassium levels

• Allergic reaction: Rash, itching, swelling under the skin, possible anaphylactic shock

• Digestive tract: Mild transient diarrhea, nausea, vomiting

• Nervous system: Tingling and numbness, headache, dizziness

• Blood: Polycythemia vera (increased production of red blood cells by the bone marrow)

• Heart: Congestive heart failure, low blood pressure, fluid accumulation in the lungs

• Eyes: Vision problems"

[BarryBuchy in reply to Hidden]

The side effects can happen with any amount of adenosylcobalamin.

[fbirder in reply to Hidden]

Try this list of nasty sounding side effects:

Metabolism and Nutrition disorders: Hyponatremia, fluid overload, fluid absorption, electrolyte imbalance

Nervous System Disorders: Cerebral edema

General Disorders and Administration Site Conditions: Burning sensation (with irrigation of eyes and skin wounds)

Musculoskeletal and Connective Tissue Disorders: Rhabdomyolysis (myoglobinuria)

Renal and Urinary Disorders: Renal failure

Other Adverse reactions which may occur in association with absorption of water for irrigation include:

Blood and Lymphatic System Disorders: Hemolysis (hemoglobinemia, hemoglobinuria)

Metabolism and Nutrition Disorders: Hypervolemia, hypoosmolality, hyperkalemia, acid/base balance disorder

Nervous System Disorders: Encephalopathy (seizure, loss of vision, lethargy, disorientation, irritability, vomiting, nausea, headache)

Cardiac Disorders: Cardiac arrest, cardiac failure, bradycardia, electrocardiogram abnormal

Vascular Disorders: Hypertension, postoperative hypotension

Respiratory, Thoracic and Mediastinal Disorders: Respiratory arrest, respiratory failure, pulmonary edema

That must be one nasty drug.

It is sterile water - rxlist.com/sterile-water-si...

[DecadesUndiagnosed]

Just as a note - I suffered with pernicious anemia for 30 years precisely because of people calling various facets of it 'rubbish and hype' - so you will forgive me if I say - calling things rubbish and hype, out of hand... is vastly more harmful on average than promoting rubbish and hype. You do not know if you are harming people, with flippant cynicism and pretending to impress everyone by being the No BS person.

The four forms of B-12 have different influences on my energy levels. Do NOT tell people that this is false unless you have extensive and dramatically sufficient deductive evidence which falsifies that principle exhaustively. And I do mean exhaustively.

The same thing with 'you pee it all out so you only need a little bit' - the amount of harm this fairy tale has done to me is enormous. I take 3 x B-12 now each day - and it has helped me enormously. I believed the 'pee it all out' lie for decades. So the 'tell it like it is' shtick is harming people folks. Stop with your smarter-than-thou crap.

Sometimes the 'No Bullmalarkey' poseurs - are the ones who are ironically the most full of malarkey.

[fbirder in reply to DecadesUndiagnosed]

I am calling it rubbish and hype. Not ‘out of hand’ but bcause of real science.

You cannot absorb more than a few 10s of micrograms - maximum. bloodjournal.org/content/11...

All forms of B12 are identical once it enters the cells. b12science.com/B12Science/T...

Anecdote is not the singular of data.

The placebo effect is powerful and real.

[palmier in reply to fbirder]

I think it is IF-mediated absorption that is limited to roughly 10 mcg at a time, not the passive non-IF absorption. It is the IF that is produced only (if any) in a limited amount at each meal. Don't mix up these two kinds of absorption.

[fbirder in reply to palmier]

There is no 'passive' absorption. Otherwise people with PA would absorb less than people without PA. But all the studies that claim to have compared oral absorption in those with PA and Controls have found the same amount is absorbed.

[palmier in reply to fbirder]

If the supplement is not taken at meals there might be no gastric juice with IF produced, so the resultat might be the same for everyone.

[deniseinmilden in reply to DecadesUndiagnosed]

Wow! I'm sorry that you've suffered so much but really appreciate your reply - excellent and well said! Thank you - on behalf of me and several other friends who have also been negatively affected by the sort of responses you are highlighting as potentially damaging. I would be dead now if I had followed this unhelpful advice in the past.

[palmier]

Sounds like one tablet corresponds roughly to a 1000 mcg hydroxycobalamin injection. 30 % of such an injection is retained, and around 1 % of an oral dose is absorbed.