Someone has just mentioned the product below. (As with most things people are trying to flog, easy to find by searching - and I do not want to put a link and there be any possibility of someone clicking and buying from it.)
Your opinions, please?
B-12 Extreme™- 35 mg , 30 Lozenges by ProHealth
#PH314 - Vitamin B12 Complex Lozenge - by ProHealth
4.5 star rating
60 Reviews
The Most Potent Vitamin B-12 on Earth
For mental acuity, energy, liver support, and detoxification
Provides all four forms of B-12
Includes the only two biologically active forms of B-12
Description
ProHealth's founder, Rich Carson, set out to develop the most potent B-12 supplement on the market - and that he did! B-12 Extreme contains the world's most potent single dose of all four forms of B-12 on the market, including the only two biologically active forms in humans - methylcobalamin and dibencozide. Low blood levels of vitamin B-12 are frequently associated with fatigue and malaise. Hydroxocobalamin and methylcobalamin have also recently gained attention from leading CFS and FM researchers and doctors.
MENTAL ACUITY - Methylcobalamin 12,500 mcg
Methylcobalamin, perhaps the most important and potent of the essential cobalamins, plays a vital part in cell growth. Particularly important for your central nervous system, it helps promote healthy homocysteine levels and helps increase the brain's focus and clarity, and the spinal cord's function.
ENERGY - Dibencozide 12,500 mcg
Dibencozide- also known as Adensylcobalamin- metabolizes essential fatty acids to produce more energy. As a biologically active form of B-12, this B-12 lozenge reacts with cells to provide muscles and nerves with bursts of energy.
LIVER SUPPORT - Cyanocobalamin 7,500 mcg
Cyanocobalamin, the most common of the cobalamins, becomes active in your liver, creating enzymes to help the body with blood formation, cell reproduction, iron utilization, and tissue synthesis, while aiding the digestion and absorption of foods.
DETOXIFICATION - Hydroxocobalamin 2,500 mcg
Hydroxocobalamin, one of the three essential cobalamins that make up the vitamin B-12 complex, helps support overall detoxification. Contained in ProHealth's sublingual B12 supplement, it also assists with methylation and energy production.
Written by
helvella
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sounds like a product that is more marketing hype than a good idea
The dose of B12 is enormous and I wouldn't recommend it to anyone who doesn't have a B12 absorption problem. It might possibly be of use to a very very small minority of people who have specific genetic variants affecting the metabolism of B12.
The amount of B12 that can be absorbed in one go is limited to about 13 mcg. So taking a 35000 mcg tablet means that about 34,987 mcg are going straight through you and down the toilet.
however, dibencozide is the name frequently used for supplements. Personally I wouldn't read too much into the use of the term.
When i worked in a care home (psychiatric) there was a man who apparently drank a whole bottle of concentrated orange juice, with the inevitable bright yellow result.
Just as a note - I suffered with pernicious anemia for 30 years precisely because of people calling various facets of it 'rubbish and hype' - so you will forgive me if I say - calling things rubbish and hype, out of hand... is vastly more harmful on average than promoting rubbish and hype. You do not know if you are harming people, with flippant cynicism and pretending to impress everyone by being the No BS person.
The four forms of B-12 have different influences on my energy levels. Do NOT tell people that this is false unless you have extensive and dramatically sufficient deductive evidence which falsifies that principle exhaustively. And I do mean exhaustively.
The same thing with 'you pee it all out so you only need a little bit' - the amount of harm this fairy tale has done to me is enormous. I take 3 x B-12 now each day - and it has helped me enormously. I believed the 'pee it all out' lie for decades. So the 'tell it like it is' shtick is harming people folks. Stop with your smarter-than-thou crap.
Sometimes the 'No Bullmalarkey' poseurs - are the ones who are ironically the most full of malarkey.
I think it is IF-mediated absorption that is limited to roughly 10 mcg at a time, not the passive non-IF absorption. It is the IF that is produced only (if any) in a limited amount at each meal. Don't mix up these two kinds of absorption.
There is no 'passive' absorption. Otherwise people with PA would absorb less than people without PA. But all the studies that claim to have compared oral absorption in those with PA and Controls have found the same amount is absorbed.
Wow! I'm sorry that you've suffered so much but really appreciate your reply - excellent and well said! Thank you - on behalf of me and several other friends who have also been negatively affected by the sort of responses you are highlighting as potentially damaging. I would be dead now if I had followed this unhelpful advice in the past.
Sounds like one tablet corresponds roughly to a 1000 mcg hydroxycobalamin injection. 30 % of such an injection is retained, and around 1 % of an oral dose is absorbed.
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What type/dose of Vitamin B12 do I need?
Can too much B12 damage the liver?
Hydroxocobalamin in the US
