Where can I get methycobalamin injectable to buy in bulk . I live in USA.

[FabiMckay]

I've been buying from a pharmacy with prescription and I pay 140 dollars for only 4 doses. I know they have to ship it with ice to keep in the right temperature. Is it possible to ship from another country to here ? I buy the serigens by 100s .

[fbirder]

Surely it would be easier to source cyanocobalamin. There’s no reason why that should not be as good as, if not better than, methylcobalamin.

[FabiMckay in reply to fbirder]

Thank you so much. I always thought that methylcobalamim was better absorbed then cyanocobalamin because is already methyled . I do have 2 mutations in my dna and I have 40 %less absorption than a normal one. Do you think I can do cyanocobal? It would be easier for me. Please advise.Thanks again

[fbirder in reply to FabiMckay]

I guess the mutations you are referring to are to the MTHFR gene. And I'll bet that they are heterozygous for C677T and A1298G. If that is the case then the only effect is to diminish the stability of the MTHFR enzyme by about 30%. The body can easily make up for this by making more of the enzyme.

Even if there were a problem with MTHFR it has no bearing at all on whether you should take methylcobalamin or cyanocobalamin.

MTHFR does one job. It converts methylenetetrahydrofolate into methyltetrahydrofolate (aka methylfolate or metafolin). So you can avoid any potential problem just by supplementing with methylfolate instead of folic acid. A very small proportion of people may find that helpful.

Methylfolate is involved in one reaction that also requires B12. The conversion of homocysteine to methionine by the addition of a methyl group.

Whichever form of B12 you take, as soon as it enters the cell the top ligand (methyl, cyano, hydroxo, adenosyl) is removed to form cob(II)alamin. This then gets converted to cob(I)alamin. When cob(I)alamin attaches to the methionine synthase enzyme, along with a molecule of methylfolate and a molecule of homocysteine, the methyl group passes from the methylfolate to the homocysteine, via the cob(I)alamin. For a very brief moment methylfolate if, indeed, formed. But it soon transfers the methyl to homocysteine, regenerating cob(I)alamin.

So both methylcobalamin and cyanocobalamin need to be converted to cob(I)alamin, before that is converted to methylcobalamin - briefly.

Taking methylcobalamin offers no advantage. It cannot take part in the reaction until the methyl group is removed.

Here's a picture - frankhollis.com/temp/B12%20...

Finally, here is what the genetic testing company 23andMe say about MTHFR - blog.23andme.com/health-tra...

"Based on the existing data, scientists at 23andMe have concluded that people should not interpret their genotypes at the common MTHFR variants as having an effect on their health."

tl:dr

There is no scientific reason why methylcobalamin should be better than cyanocobalamin. And plenty of reasons why it's worse. ncbi.nlm.nih.gov/pmc/articl...

[FabiMckay in reply to fbirder]

Oh my so much good information! You are really good! I take everything you said. I was going to get my injections in another pharmacy but your explanation was very easy to understand. Now my injection can 0l be covered by my heath insurance.

Can you help me here too? My homoceystein is always high but my levels of b12 are very high too...I do not understand why and also why I still have all the symptoms of b12 deficency.

Thank you so much!

[fbirder in reply to FabiMckay]

High homocysteine can have many causes, but the most common are B12 deficiency or folate deficiency. How are your folate levels? If they are low you need to take folic acid. If they are high I would try taking methylfolate supplements.

[FabiMckay in reply to fbirder]

I'm going to check my levels and follow your advise. Thank you a lot!

[wedgewood]

I agree with fbirder , but if you are hell-bent on using Methycobalamin, a US source is vitaminquick.com . If you put some in the basket , but don’t pay , they will get back to you eventually and offer it at a lower price !

[FabiMckay in reply to wedgewood]

Thank you so much. I always thought that methylcobalamim was better absorbed then cyanocobalamin because is already methyled . I do have 2 mutations in my dna and I have 40 %less absorption than a normal one. Do you think I can do cyanocobal? It would be easier for me. Thanks.

[wedgewood in reply to FabiMckay]

I really do not know , so I can’t advise because you mention mutations , of which I have no knowledge. fbirder is a scientist and more qualified to answer that question . I can only speak about my own experiences , and I don’t have any mutation issues as far as I know . But I tried Methylcobalamin, and found it no better than Hydroxocobalamin, which is the commonly used B12 here in the U.K. . I have no experience at all of Cynocobalamin, which is hardly not used in U.K. . Sorry I can’t help you on this , but I’m sure that fbirder could . He knows about mutations .

[FabiMckay in reply to wedgewood]

Thank you anyway!

[EllieMayNot]

You can also use hydroxocobalamin. You can order in bulk from mycare.de or bodfeld-apotheke.de/ in Germany. Shipping from mycare is less expensive. The mycare website converts to English, top right hand side of web page. I have to use Google Translate for bodfeld.

Some sources claim hyroxoB12 stays in the system longer than cyano:

pubchem.ncbi.nlm.nih.gov/co...

"Both hydroxocobalamin and cyanocobalamin are excreted mainly via the kidneys in dogs. In human volunteers, hydroxocobalamin was also excreted mainly via the renal route (58-74% of total clearance). The mean half-lives for free cobalamins were 3 hr in the rat, 6 hr in the dog and 28 hr in humans. For cyanocobalamin, the half-lives were 0.3 to 0.5 hr in rats, 0.8 to 1hr in dogs and 9.3 + or - 3.2 hrs in humans."

[FabiMckay]

Thank you. I'm going to check it out!

[Elgrimshaw]

I get methylcobalamin from a compounding pharmacy in NY and I get 5 doses for $59.00

[FabiMckay in reply to Elgrimshaw]

Can u send me the name of your pharmacy?

[FabiMckay in reply to FabiMckay]

Thank you so much!

[fancycake1946]

Ii

[fancycake1946]

I get mine at drug mart. I paid 15.00 for two weeks worth.

[Elgrimshaw in reply to fancycake1946]

Where is drug mart?

[bquoss]

Hello, I am also in the U.S. I used methylcobalamin injections for several years but then could not get it. I've used cyanocobalamin for the last 2 years and have not noticed any difference. In fact, the cyano might be working better. Good luck with finding whichever you choose and doing well.

[FabiMckay in reply to bquoss]

Thank you

[BirdlessBox]

I think the one we get prescribed here is Hydroxocobalamin and I can also buy it over the counter unprescribed for $12 per pack of 3 ampoules. I have no idea why yours are so extremely expensive other than what we hear about the whole medical system in the U.S. is a complete wrought. I'm sure you'll be able to access it much cheaper from somewhere else.

[FabiMckay in reply to BirdlessBox]

Thanks! I'm looking to buy it someplace else.