Good methyl folate

[Heidiv]

Hi all, this is such a wealth of information. I am new to PA and have been having injections 1000 Hydrocobalamine for 6 weeks now. The hematologist prescribed twice a week but this is practically not realistic as I'm not self injecting yet.

My question is now: I'm going to make the switch to Methylcobalamin (from a reliable source thanks to this forum) because I suspect I have MTHFR and the Cyanocobalamine and the Hydro seem to be helping, but not enough.

I was wondering at what dosage people have the MethylB12 (also once a week?).

Also I heard I would need to take good Methyl folate to take with it. What brands are you taking and from where?

Thanks a lot!

[fbirder]

If you have a problem with MTHFR then taking methylcobalamin will make no difference.

MTHFR is responsible for converting methylenetetrahydrofolate into methyltetrahydrofolate (MTHF). A molecule of MTHF combines with a molecule of the enzyme Methionine Synthase, along with a molecule of cob(I)alamin and a molecule of homocysteine. The methyl group from the MTHF passes to cob(I)alamin and then one to the homocysteine, forming methionine.

As you can see - no methylcobalamin. The cob(I)alamin is produced from B12, but it is produced from all forms of B12, not just methylcobalamin.

If you do have a problem with MTHFR then the only supplement that might help is methylfolate (which is MTHF). I take the cheapest methylfolate I can get from Amazon. amazon.co.uk/gp/product/B01... It's 1000 mcg, rather than the recommended 400 mcg, but it's the price that's the winner for me.

[Heidiv in reply to fbirder]

Hi, thanks for your answer! Does that mean that you don't take any vit.B12 at all, just methyl folate? I'm a bit confused now. Taking supplements by mouth is hard because I have a very sensitive GI system and I was told my body couldn't absorb well.

I suppose I should get tested for MTHFR to be sure.

[olga67 in reply to Heidiv]

I do not think that @Fbirder takes methylfolate on its own. Supplementing folate in the presence of B12 deficiency can cause nerve damage.

[fbirder in reply to Heidiv]

I inject hydroxocobalamin twice a week.

I started taking methylfolate because I am homozygous for the C677T mutation (the only one with any evidence of any bad effects). That was before I'd read up on the subject and realised that most of the stuff in the interwebs was rubbish. So I stopped the methylfolate as went on to folic acid.

The story about why I went back onto the methylfolate is related here - healthunlocked.com/pasoc/po....

I wouldn't advise getting tested for the MTHFR mutation. And nor would the top genetic testing company 23andMe - blog.23andme.com/health-tra...

Based on the existing data, scientists at 23andMe have concluded that people should not interpret their genotypes at the common MTHFR variants as having an effect on their health.

What I would advise is that you try methylfolate for three months to see if it makes any noticeable difference.

[Heidiv in reply to fbirder]

Great, thanks for your reply!

[Hidden]

I use this Jarrow formulas methyl folate 400mcg. On Amazon for £9.99 for 60 so two months supply. I do well on it.

[fbirder in reply to Hidden]

Yes, that's the only disadvantage. It is expensive. A lot of people will find £60 a year a lot, especially compared to £3 a year for folic acid.

[Heidiv in reply to Hidden]

Thanks, just ordered a bottle from a Dutch pharmacy (I'm in Belgium)