Full blood count near top range mchc

[Ldhall]

Full blood count

Haemoglobin concentration 151 g/L [120.0 - 150.0]

Above high reference limit

Total white blood count 10.7 10*9/L [4.0 - 11.0]

Platelet count - observation 262 10*9/L [150.0 - 400.0]

Neutrophil count 7.1 10*9/L [2.0 - 7.5]

Lymphocyte count 2.7 10*9/L [1.5 - 4.0]

Monocyte count - observation 0.6 10*9/L [0.2 - 1.0]

Eosinophil count - observation 0.3 10*9/L [0.0 - 0.5]

Basophil count 0.1 10*9/L [0.0 - 0.1]

Red blood cell count 4.85 10*12/L [3.8 - 4.8]

Above high reference limit

Haematocrit 0.423 L/L [0.36 - 0.46]

Mean cell volume 87.2 fL [80.0 - 100.0]

Mean cell haemoglobin level 31.1 pg [27.0 - 32.0]

Mean cell haemoglobin concentration 357 g/L [320.0 - 360.0]

Nucleated red blood cell count 0.0 10*9/L

I am also pregnant 11 weeks. I have ulcerative colitis too.

Would the near top mchc and mch point towards b12 deficiency,

Plasma ferritin level 44 ug/L [11.0 - 307.0]

Plasma folate level > 25.0 ug/L [3.8 - 25.0]

been supplementing with folic acid as pregnant

Serum transferrin level 2.46 g/L [1.9 - 2.8]

Serum total 25-hydroxy vitamin D level 114 nmol/L

Serum vitamin B12 level 587 ng/L I had been taking high dose b12 5000 sublinguals in January so think I tested too early for clear result. Does mchc and mch lean towards b12

What do these look like please

[Gambit62 Administrator]

it could be an indication of macrocytosis - larger rounder red blood cells.

Macrocytosis is a symptom of B12 and folate deficiency - though your results don't show folate deficiency.

If you have a deficiency then most likely that it is at the cell level rather than absorption issues. MMA/homocysteine tests might help to clarify.

[Ldhall in reply to Gambit62]

Thank you Gambit62 , if it is not absorption issue what do you think might be the issue to cause it at cell level, would homocysteine be any use as i have been taking folic acid for pregnancy wonder if that lowers homocysteine levels. thank you for your reply.

[Gambit62 Administrator in reply to Ldhall]

all tests need to be done in a context.

some people have genetic variants that affect how well their cells are able to run processes that use B12 and may need higher levels of B12 anyway as a result. However, if you were supplementing and raised your serum B12 levels then that may have resulted in another reaction kicking in which affects the efficiency with which your B12 is transferred from your blood to your cells, meaning that you now need much more B12 in your blood for enough to get through to your cells.

homocysteine is a measure of what is happening in your cells - it will build up if folate or B12 are low - having folate levels high means it would be a good test for B12.

MMA is another measure of what is happening in your cells - it will build up if folate is low but will also be raised by other factors - so needs to be looked at in the context, particularly of kidney function.