I've been taking sublingual for months now. I would like to know WHY I'm always low in range (between 150 and 200) without supplementing, but would prefer to keep supplementing instead of quitting for months.
Are MMA/Homocysteine/Active B12 tests reliable while supplementing?
Written by
Laura221
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My understanding (I'm not medically trained) is that MMA/Homocysteine/Active B12 (transcobalamin) test results can be affected by prior supplementation.
Do you have recent results for folate, ferritin and full blood count tests? My understanding is that iron, B12 and folate metabolism is interlinked so l think good levels of each are needed.
Have you had an Intrinsic Factor Antibody test? IFA test can help to diagnose PA but it's still possible to have PA even if IFA test result is negative or normal range.
In UK, two first line tests are recommended for Coeliac disease.
1) tTG IgA
2) Total IgA
Have you had both tests? My experience is that the Total IgA test is not always done. I think it's important because people with IgA deficiency will need different tests for Coeliac disease.
Unfortunately the MMA and homocysteine tests would require you to stop supplementing for at least three months. I have stopped all supplements of B12 at the moment for a second MMA test. I'm now wondering whether it is the best thing, as I feel awful. To be honest, I didn't think that the extra B12 was working as the tiredness didn't really go away, but other symptoms are returning. Now I have a sore tongue again and pins and needles seem to be worse, I have a feeling that I will deteriorate more as time goes on. Not sure it's actually worth it!
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