Pernicious Anaemia Society

Confused MS or B12 deficiency??????

I was diagnosed with MS 9 years ago and upon further investigation I think I have been misdiagnosed. I have come to a point now where I am desperate to discover if I am actually b12 deficient or not.

When I was 1.5 yrs old I went into hospital with diarehia and a swollen stomach and pale skin, the doctor at the hospital kept me in for 4 days and treated me for folate deficiency anemia. I left the hospital with the same swollen stomach with which I entered and the doc put it down to constipation.

I always had a big distended stomach as a child and in to my later life, does this suggest that I had penicious anemia? Which has caused scarring on my brain and spinal cord which led to an incorrect MS diagnosis.

What is worse is I resently had a private heamotoligist take bloods and test me for the following:

1. full blood count

2. anti intrinic factor antibody screen

3. folate serum

4.thyroid stimulating hormone

5. Vit b12 Cyanocobalamin

The qustion I am asking myself is was the test carried out a SERUM b12 test or an active b12 test which would give very differing results...

2 Replies

A serum B12 will give different results to active B12. But that's because only 0,2 fraction of the B12 in your blood is 'active'. That's the same for just bout everybody so it is taken into account when they do the ranges.

If you really want to know - ask for MMA and total homocysteine tests.


I think the same thing has happened to my brother. He either has both M.S and B12 deficiency or Pernicious Anemia or is misdiagnosed. A very difficult situation to be in. The Gp wouldn't test his MMA or Homocysteine said it was too expensive but very grudgingly gave b12 loading doses.

I won't hijack your post but if you are interested you can read past posts by clicking on peoples ID. And write personal messages.

Good luck.

M 😀


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