Yesterday when I woke up to my alarm I had the worst charley horse I've ever had in my entire life. It brought tears to my eyes even though it only lasted for 20-30 seconds. The weird part is that it happened the very second I moved to get up. Now, the next morning, it still is sore and stiff laying in bed. My calf muscle seems to not be relaxed completely either. I have been diagnosed with PA and have been on bi-weekly cyanocobalamin shots for 4 months now. I am also taking gabapentin for RLS, iron supplements for anemia, d3 vitamins, acne medication, a probiotic, a multivitamin, melatonin, and lexapro for anxiety. I was wondering if anyone knew what caused the muscle cramp or if it's related to any of the medications/supplements I'm taking? Also, is it normal to still have pain/tension in my muscle? I am an athelete currently in the off season and just turned 20 if that helps.