Numbness and sharp pain after bedoyecta tri shot

[Amtz420]

Hello all, hoping to find some answers here as I'm not entirely sure where else to post. This was the main forum where I found people with adverse reactions to the b12 shot so figured I'd ask here. I recently strained my sciatic nerve and after some massage therapy I got better but then someone how I strained my calf which the massage therapist made better but then after that got better I began experiencing a dull ache in my inner thigh. Now all this was tolerable and the thigh pain was subsiding slowly but surely, until my massage therapist suggested I take the Bedoyecta Tri shot from Mexico. It contains b1, b6, b12, and folic acid. Shortly after I received the shot on my butt, the area from the injection site down to my mid thigh went numb. I was told this was a normal side effect and would subside, but maybe 3 days after I was sitting in bed and as I got up I felt a sharp burning pain in the numb area, I attributed this to the feeling trying to come back into the area but it's been 6 days now and I'm still experiencing pain. It isn't constant pain but is sensitive to touch and any movement that tugs at the area (like flushing the toilet) sets off some pain. I'm not sure if this is due to the shot or something else as I did not have these symptoms before the shot. Any advice?

[Amtz420]

I was also told the person who injected me MAY have nicked a nerve considering my sciatic nerve on that side had been the one bothering me and the pain I feel is just the nerve healing. But not sure what to think about that since I didn't feel anything out of the norm when the shot was administered. Felt like any regular shot except for the fact that it went numb.

[pvanderaa in reply to Amtz420]

The location should be the upper outer quadrant if you drew the letter t (cross shape) on the buttock cheek.

The injection may have hit a nerve to cause the numbness.

[pvanderaa]

The ingredients of the injection bind to muscle tissue and the pain of pressure on the site can last a couple of weeks.

What is also interesting is that if you get the same injection or just B12, this site will get sore again.

I alternate buttocks and the opposite cheek hurts when I inject the new one. Sorry if this is TMI.

Using the muscle releases the injection into the blood stream. That is how these injections are stored in the body since B12 is water soluable and you pee most of it away in the first two days.

You probably do not have a B12 absorption issue so your gut keeps recycling the B12 and so the pain is lasting a little longer.

[Foggyme Administrator]

Hi Amtz420. From what you say it is unlikely that the reaction you describe is due to a systemic allergic reaction to the injection.

Damage to the sciatic nerve can occur when incorrect injection technique is used, when the injection is not sited in the right area of the buttock (upper outer quadrant, well away from the sciatic nerve). (There are published studies about this if you do a search on the Internet).

The ongoing nerve symptoms you describe are not 'normal' reactions to an injection in the buttocks.

However, this kind of injury is usually found in children where the injectable area is far smaller. But it's not unheard of in adults.

Any B12 still circulating in the system (a systemic reaction) will not produce the localised nerve symptoms or pain you describe.

It's impossible to tell from a few words whether this sort of damage has actually occurred so the best course of action would be to consult a medic for further assessment and advice.

Please can I just add a comment to reassure forum members who self-inject B12: this type sciatic nerve damage cannot occur when injecting into the upper outer thigh since the injection site is well away from the path of the sciatic nerve.

Good luck with your medic 👍

[DrLarry]

I used Bedoyecta Tri I bought in Culiacan from a pharmacy near the Botanic Gardens on advice from the Pharmacist. I injected once in the right buttocks and that is ok, but I switched the next 3 days to injections in the right and left vastii lateralii as its an easy site to access. Then the pain and numbness began. That has lasted in both thighs since Christmas time. I have one injection left that I wont take. I believe it is more than a coincidental mechanical injection damage. I believe it is a toxic concentration to nerves there. I am a dentist and know a little about toxic concentrations and nerve damage as well as mechanical injection damage. Both may last. But both thighs is more likely toxic than mechanic damage.

[helvella in reply to DrLarry]

I have posted this before - and from what I could easily and quickly find, Bedoyecta Tri contains 50 milligrams of Pyridoxine:

The taking of B-complexes, and of just B6, has often been discussed here. I, along with several others, have pointed out that high doses of B6 should be avoided as they can cause neuropathy - one of the symptoms that it is sometimes taken to help relieve.

This paper, from 2017 has an explanation for this phenomenon.

What it doesn't do is give information about doses. It appears to say that, while pyridoxine can cause neuropathy, other forms of B6, such as pyridoxal-5'-phosphate, do not cause this issue.

Toxicol In Vitro. 2017 Oct;44:206-212. doi: 10.1016/j.tiv.2017.07.009. Epub 2017 Jul 14.

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function.

Vrolijk MF1, Opperhuizen A2, Jansen EHJM3, Hageman GJ4, Bast A4, Haenen GRMM4.

Author information

1 Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands. Electronic address: [e-mail].

2 Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands; Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The Netherlands.

3 National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

4 Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands.

Abstract

Vitamin B6 is a water-soluble vitamin that functions as a coenzyme in many reactions involved in amino acid, carbohydrates and lipid metabolism. Since 2014, >50 cases of sensory neuronal pain due to vitamin B6 supplementation were reported. Up to now, the mechanism of this toxicity is enigmatic and the contribution of the various B6 vitamers to this toxicity is largely unknown. In the present study, the neurotoxicity of the different forms of vitamin B6 is tested on SHSY5Y and CaCo-2 cells. Cells were exposed to pyridoxine, pyridoxamine, pyridoxal, pyridoxal-5-phosphate or pyridoxamine-5-phosphate for 24h, after which cell viability was measured using the MTT assay. The expression of Bax and caspase-8 was tested after the 24h exposure. The effect of the vitamers on two pyridoxal-5-phosphate dependent enzymes was also tested. Pyridoxine induced cell death in a concentration-dependent way in SHSY5Y cells. The other vitamers did not affect cell viability. Pyridoxine significantly increased the expression of Bax and caspase-8. Moreover, both pyridoxal-5-phosphate dependent enzymes were inhibited by pyridoxine. In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5'-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

Copyright © 2017 Elsevier Ltd. All rights reserved.

KEYWORDS:

Neuropathy; Neurotoxic; Pyridoxine; Supplements; Vitamin B6

PMID: 28716455

DOI: 10.1016/j.tiv.2017.07.009

ncbi.nlm.nih.gov/pubmed/287...

healthunlocked.com/thyroidu...

[DrLarry in reply to DrLarry]

Thanks for reading and responding to my post. I was looking for some discussion about the numbness that you helped me get.