I have double snips in the above genes and so I think re-cyling B12 is compromised. Gambit, Clare and May may find this interesting. Wikipedia article on Allergic rhinitis and scroll down to management using B12.
MTRR A66g and MTRR 11 double snips an... - Pernicious Anaemi...
MTRR A66g and MTRR 11 double snips and B12
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Hmmm. I've just checked and I have two mutations on that gene - rs2287780(C;T) and rs3776463(C;T) - both of which are only present in 5% of the population. So the combination should only be in 25 per 10,000 people.
Here's a description of this gene -
"Yasko Methylation Methionine synthase, coded by the MTR gene, has a B12 attached to it. The Methionine synthase takes a methyl group from methyl folate and attaches it to its B12, then it attaches it to a molecule of homocysteine, turning it into methionine, which in turn becomes SAMe. After 1000-2000 times doing this, the B12 gets turned into a useless form, and MTRR turns the B12 back into the useful form so that the molecule of MTR can keep working. The MTRR mutations make this enzyme less active, suggesting a need for more B12."
Hi
I wondered where you got the genetic info from? Thanks
Hi,
A few years ago I had my autosomal DNA tested at FTDNA. This was done purely for genealogical purposes. I was investigating my family tree and wanted to see if any relatives had also been tested (the answer was 'no').
Some time later I discovered a website - Promethease - that, for a very small fee, would check your data for known medical mutations (Single Nucleotide Polymorphisms - SNPs or snips).
On FTDNA - familytreedna.com - the test is called 'Family Finder' and costs $99 (a lot cheaper than when I had it done).