Parkinson's Movement
12,683 members11,273 posts

Did you know that only half of our disease is being treated?

It has long been known that we also lose a lot of our noradrenaline neurons too. Recent research shows that it may be that noradrenaline loss is primary cause of most PD symptoms including the motor ones. It also is looking like it is the locus of dyskinesia, So what does this mean for me? It means you may have another way to treat this without experiencing the dark side of levodopa. It means you may be able to significantly decrease your intake of ldopa and live many more years without invasive brain surgeries. If you are at all considering DBS, please read it and discuss with your doctor. The drug classes involved are used for other conditions but it is worth asking your doctor.

Here is the skinny (the abstract)

In the present review, we analyze the latest evidence for the implication of NA in the pathophysiology of PD obtained from animal models of parkinsonism and from parkinsonian patients. Recent studies have shown that NA depletion alone, or combined with DA depletion, results in motor as well as in non-motor dysfunctions. In addition, by using selective agonists and antagonists of noradrenaline alpha receptors we, and others, have shown that a2 receptors are implicated in the control of motor activity and that a2 receptor antagonists can improve PD motor symptoms as well as l-Dopa-induced dyskinesia. In this review we argue that the loss of NA neurons in PD has an impact on all PD symptoms and that the addition of NAergic agents to dopaminergic medication could be beneficial in the treatment of the disease.

4 Replies

So what are the do we have to do. Too much medical jargon for me to understand. Please elaborate some of this information. Thanks.


I think that many of us think that the dopamine route is too narrow and this finding is exciting and extremely plausible. I hope this thread runs and runs so we increase our knowledge and can discuss other options with our neurologists.

Thank you Conductor 71 for bringing it to our attention.


1 like

Conductor71 could you please explain it in so I can understand what this means. I would like to discuss with my Dr. Anything that gives us hope!


A very on-target post from 5 years ago. Note that medical jargon has changed in recent years. Noradrenaline has come to be called norepinephrine. First cite in this thread provides an important link. See also posts about Locus coeruleus (ceruleus).

1 like

You may also like...