Taiwan reveals new findings to treat Park... - Cure Parkinson's

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Taiwan reveals new findings to treat Parkinson's disease

Farooqji profile image

In this pioneer study, PS128 was used as adjunct treatment for a group of twenty-five PD patients for three months. Participants continued to take their own prescribed anti-Parkinsonian medications throughout the study. Significant improvements were shown in motor symptoms and in subjective reported quality of life.

biospectrumasia.com/news/98...

55 Replies

Lactobacillus plantarum PS128 is a specific strain of Lactobacillus plantarum, a bacterium of the genus Lactobacillus. It won "Probiotic Product of the Year" at the 2018 NutraingredientsAsia Awardsen.wikipedia.org/wiki/Lacto...

its readily available and can be started taking right away

amazon.fr/Synergia-PS128-Ne...

medicine photo
parkylot profile image
parkylot in reply to Farooqji

Thank you for this. Although my search for this PS128 strain on US Amazon failed to bring up the same product. I would imagine the probiotic should specify PS128. Not all probiotics are the same ?

park_bear profile image
park_bear in reply to parkylot

Lots of products with Lactobacillus plantarum on Amazon US but none are PS128. Presumably PS128 needed.

laglag profile image
laglag in reply to park_bear

I found this on Amazon & ordered 60 days worth. I hope it's the same thing.solaceprobiotic.com/product...

park_bear profile image
park_bear in reply to laglag

Good find. As far as I can tell you have to order direct from the vendor rather than from Amazon.

simonasays profile image
simonasays in reply to laglag

wondering if you have anything to report on Solace? My father is considering trying it...

laglag profile image
laglag in reply to simonasays

No I haven't tried it yet. I keep thinking about it, but it kind of scares me. I want to talk to my neurologist first. Something made me buy it. It's not going to help me sitting in the refrigerator! I'll let you know when I start it.

in reply to laglag

I have ordered it too. It’s in my fridge waiting for me also!

simonasays profile image
simonasays in reply to

well, my dad purchased it without talking to me and in his usual impulsive fashion is giving it a go. So I will be sure to report it once he has anything to report.

AmyLindy profile image
AmyLindy in reply to simonasays

Sounds familiar;)

Farooqji profile image
Farooqji in reply to simonasays

He is using his impulsive behaviour in a good way

Sapeye2020 profile image
Sapeye2020 in reply to laglag

here is some details about the owner and their research.

oryxbiomed.com/

Nanismami profile image
Nanismami in reply to Farooqji

I have been taking ps128. Product can be purchased at solace.comIt comes from Taiwanese fermented mustard greens

Farooqji profile image
Farooqji in reply to Nanismami

Have you felt any improvement so far

Bit more detail here:prnewswire.com/news-release...

Its basically an ad for the company. 3 month trial without placebo essentially proves nothing. No harm trying it though.

The company seems genuine as they have straight away refused to sell it to me due to the reason for not being able to send it under controlled temperature to my country

Ya, I'm not saying it's a scam. Was just saying tye trial design makes it pointless

Please see link

solaceprobiotic.com/pages/w...

solaceprobiotic.com/pages/b...

solaceprobiotic.com/product...

laglag profile image
laglag in reply to John_morris71

Do you know if anyone has tried this or if anyone knows much about it? It sounds promising??

John_morris71 profile image
John_morris71 in reply to laglag

No, I have not yet tried it for my mother. I just found it. Will try in another month or two. I would want to try it for at least 4-6 months at a stretch before deciding.

Please let us know about the results after use for some time. Unfortunately none of the supplier provide shipping to my country

laglag profile image
laglag in reply to Farooqji

I appreciate you sending this information. I'm going to ask my neurologist and internist to see if they know anything about it.

Hi There,

Wondering if you began Solace for your mother?

Yes, I have started Solace and it has been a couple of weeks. Giving her 1-0-1 for now. Plan on giving her this dose for another 6 months. I may make it 1-1-1 the max dose as suggested in the box ( after a couple of months). Will provide an update by end of June/early July.

Despe profile image
Despe in reply to John_morris71

Hi John and everyone on Bio-Kult,

Will you stop Bio-Kult and start Solace? Solace sounds very promising but so did Bio-Kult. :)

Has anyone come across this?

I had contacted the main Taiwanese manufacturer about their sub-suppliers. Their reply was as under:"I’m glad to receive your email. Currently, we do not have a distributor that covers your country. PS128 is a delicate probiotic that is best kept refrigerated and shipped via cold chain, and logistically, that is quite difficult in your country. Our Singapore distributor, Multibiotics | Activhealth | Healthy Mind, Healthy Body, may be an option. Please contact them directly and see.

If there is anything else I can help with, please let me know.

Only the best,

Sam Noble

Int'l Dept. Product Manager, Bened Biomedical

mob: +886-9-7831-4917 | tel: +886-2-2511-1122

benedbiomed.com"

Leslim profile image
Leslim in reply to Farooqji

Singapore activhealth.com.sg/

Thank you Farooqji for this post .

here is a report on LB PS 128 by Science Direct

published Nov. 2020

sciencedirect.com/science/a...

Abstract

Evidence suggests that the Parkinson’s disease (PD) pathogenesis is strongly associated with bidirectional pathways in the microbiota-gut-brain axis (MGBA), and psychobiotics may inhibit PD progression. We previously reported that the novel psychobiotic strain, Lactobacillus plantarum PS128 (PS128), ameliorated abnormal behaviors and modulated neurotransmissions in dopaminergic pathways in rodent models. Here, we report that orally administering PS128 for 4 weeks significantly alleviated the motor deficits, elevation in corticosterone, nigrostriatal dopaminergic neuronal death, and striatal dopamine reduction in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mouse models. PS128 ingestion suppressed glial cell hyperactivation and increased norepinephrine and neurotrophic factors in the striatum of the PD-model mice. PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the gut microbiota. L. plantarum abundance was significantly increased along with methionine biosynthesis-related microbial modules. PS128 also suppressed the increased family Enterobacteriaceae and lipopolysaccharide and peptidoglycan biosynthesis-related microbial modules caused by MPTP. In conclude, PS128 ingestion alleviated MPTP-induced motor deficits and neurotoxicity. PS128 supplementation inhibited neurodegenerative processes in PD-model mice and may help prevent PD.

Enjoy!

Hi Jaberal. Welcome back

Thanks

I have received mine today from Solace and will start with one per day and gradually up to 3 per day.

laglag profile image
laglag in reply to mauigirl18

Keep us updated please. I have some in my fridge but haven't tried them yet. Good luck!

mauigirl18 profile image
mauigirl18 in reply to laglag

I will! Thank you!

laglag profile image
laglag in reply to mauigirl18

I started using cinnamon a few weeks ago. I'll let you know how that works.

mauigirl18 profile image
mauigirl18 in reply to laglag

Great! I used it briefly and then stopped. Curious to know how you do with it.

laglag profile image
laglag in reply to mauigirl18

Did it help you even a little bit?

mauigirl18 profile image
mauigirl18 in reply to laglag

It may have. I wasn't sure. I started other things at the same time and am trying to isolate to see what really works.

B1 seems to really help. I'm not on any meds yet. Trying supplements etc first.

Farooqji profile image
Farooqji in reply to laglag

Why are you hesitating to use it? If it doesn't benefit you, It will not harm you either

laglag profile image
laglag in reply to Farooqji

The description includes the word "psychobiotic" . That kind of scares me.

Farooqji profile image
Farooqji in reply to laglag

By definition Psychobiotics is a term used in preliminary research to refer to live bacteria that, when ingested in appropriate amounts, might confer a mental health benefit by affecting microbiota of the host organism.[1] Whether bacteria might play a role in the gut-brain axis is under research.en.m.wikipedia.org/wiki/Psy....

laglag profile image
laglag in reply to Farooqji

Thanks for your help, knowledge, encouragement.About a week ago I started taking Protandim, again, (I took it a few yrs ago, but I took 1/day & now I've been taking 2/day (1 morning and 1 night). Taking 1 helped give me an overall feeling of well-being. Recently a friend talked to a lady from India in the drugstore and she was buying 1,000 mg of Ashwagandha. My friend was looking for something to help with stress so she asked the lady if it worked. The lady said yes & it also is really good for PD. My friend, which happens to be my boxing coach, was shocked because she had nothing on that would show that she was involved with any thing about PD. The lady said in India they use it a lot for PD. My coach thinks it was a "sign" for her to be there at that particular place and time. So I started taking 2 Protandim a day and I've been feeling remarkably good. I'm going to keep taking the Protandim for another week and see how I feel and at that time I will try the PS128 and I'll let you know how that goes.

BTW.... In 1 Protandim there is:

Milk thistle 225 mg

Bacopa 150 mg

Ashwagandha. 150 mg

Green tea. 75mg

Turmeric. 75 mg

Keep fighting!🥊

in reply to laglag

Hi DebbieAre you still taking this? I use powder forms of these same supplements but I wonder if pills would be better at making it past my stomach acid.

laglag profile image
laglag in reply to

Yes, but not every day.

Farooqji profile image
Farooqji in reply to mauigirl18

Thanks for sharing. Anxious to know the results. Please keep us updated. I can't purchase it due to the reason mentioned above

Hello are all,Any update you care to share?

Protansim? Solace? PS128?

Leslim profile image
Leslim in reply to enjoy2013

activhealth.com.sg/ Singapore

Millbrook profile image
Millbrook in reply to Leslim

Please share your results on PS 128

Leslim profile image
Leslim in reply to Millbrook

Hi Millbrook, I just started on the following multibiotics today.. Will keep u all posted

Multibiotics from Activ Health
Millbrook profile image
Millbrook in reply to Leslim

How is it going Les? My husband is still on it. Can’t do without and he is as well as can be. Praise God!

laglag profile image
laglag in reply to enjoy2013

I bought PS128 from Solace a couple of months ago and have tried it 2 different times and after a couple of days it makes me start shaking. he shaking is more like being cold rather than a tremor. It happens about an hour before my meds are due and it lasts about 45 minutes after I take my meds. That's happened to me when I've tried other probiotics and I'm not sure why.

Protandim helps after I take it for about a week but doesn't seem to help more than 2 weeks, so I take it every once in awhile. The way it helps is it takes most of my symptoms away during my on periods and my off times are shorter and not as bad.

I know this sounds confusing but it's confusing to me also.

Unless it's some type of "placebo effect"?

I don't feel it looks like placebo effect.It sounds like you are maybe more responsive to dopamine so you have less "dopa-resistant symptoms" in on times and you are less deeply off in off times, it seems to be a change on the response amplitude rather than length (time). To make the difference with dopamine synthesis you could try increasing a bit your levodopa dose.

But my interpretation is very human-centric. Biology works in very mysterious and unpredictable ways. This is why, we don't always understand.

And the shaking, could it feel like chills?

laglag profile image
laglag in reply to enjoy2013

They are similar to chills, but they aren't.

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