MELATONIN FOR COVID-19: One possible... - Parkinson's Movement

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MELATONIN FOR COVID-19

chartist
chartist

One possible problem for moderate to severe Covid-19 patients is the potential for significant damage to the lungs and possibly other organs like the liver based on what is being seen in patients. At this point, treatment options to try and prevent, repair or ameliorate this damage is very limited and not necessarily a very high priority for doctors yet, but still important to the patient in the long run to maintain good health quality overall. Toward that end, I would like to talk about one of my favorite supplements that I have previously mentioned on this forum that may have benefit to help these patients have a more complete recovery of the lungs and possibly other organs. The aftermath for patients with Covid-19 has not been discussed at length yet because it is not currently the highest priority for doctor's treating these patients. Keeping them alive is obviously a primary concern right now, but preventing or ameliorating the significant amount of collateral and direct damage caused by Covid-19 is very important also. That subject, in time, will be quite popular as more people reach the recovery phase of Covid-19. For many people who fall into the "high risk groups", this information may be useful and timely to reduce your chances of succumbing to the disease if infected and if some scientists are right in their thinking that the virus can potentially mutate and return seasonally, similarly to the seasonal flu, then melatonin certainly seems like a very useful adjuvant treatment to keep in mind from this point forward! If you survive the virus once and develop antibodies to it that will be very good, but if the virus mutates extensively, there is a chance that those antibodies may not be effective against the new strain similarly to vaccines for the flu, which sometimes work against the new strain and sometimes don't as witnessed by people who have gotten the flu shot and still got the flu.

Melatonin, has shown itself to be protective of the major organs of the body in many studies, which includes the lungs among its many potential health benefits. There are several forum members currently using melatonin including myself so this could be useful information for them as well as other members who are trying to be as prepared as possible to deal with Covid-19. Below is a link to a recent article that discusses the potential utility of melatonin as it would relate to Covid-19. Melatonin is just at the beginning of testing in Covid-19 patients with initial positive results. This article mainly discusses the effects of melatonin as it might relate to Covid-19 and includes its antiviral and anti-ARDS qualities among many other qualities. The article describes melatonin as "having a high safety profile" and suggests it might be useful before, during and after the disease process has ended. Doctors may have a bit more latitude in using melatonin compared to all of the prescription drugs that have been mentioned on this forum and across the internet since melatonin is an OTC supplement sold at drug stores and big box item stores and almost all online supplement suppliers. I will copy and paste the link to the complete article from PubMed first and then copy and paste the abstract below that link :

ncbi.nlm.nih.gov/pmc/articl...

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Life Sci. 2020 Jun 1; 250: 117583.

Published online 2020 Mar 23. doi: 10.1016/j.lfs.2020.117583

PMCID: PMC7102583

PMID: 32217117

COVID-19: Melatonin as a potential adjuvant treatment

Rui Zhang,a Xuebin Wang,a Leng Ni,a Xiao Di,a Baitao Ma,a Shuai Niu,a Changwei Liu,a,⁎ and Russel J. Reiterb,⁎⁎

Author information Article notes Copyright and License information Disclaimer

Go to:

Abstract

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.

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Here is a link to an article that gives an idea of which organs can be impacted by Covid-19 which further illustrates why melatonin might be a very useful adjuvant treatment option which doctors can add to their arsenal against Covid-19. That arsenal is relatively small at this point, but hopefully will continue to expand.

washingtonpost.com/health/c...

Since the multiple health benefits associated with melatonin may apply in the case of this disease in multiple ways, it may be worth saving this post for future reference for yourself or a family member or friend to show to their doctor to see if it is something that will be compatible with all that they are taking and safe for you to take. ""I can not recommend melatonin to anyone as I am not a doctor"", but your doctor can. I do use it daily myself as I have previously stated on the forum for multiple reasons. Melatonin is mainly thought of as an over the counter sleep aid, but its abilities go far beyond being a common sleep aid for some people. Not everyone can tolerate melatonin and that is another good reason to include your doctor in that decision making process. The majority of people do tolerate melatonin well and it is naturally produced in the body by the pineal gland as daylight turns to night time. There are melatonin receptors found throughout the body suggesting that the body does have uses for it. Unfortunately melatonin production declines very significantly as we age and that may possibly be one contributing factor as to why older people do not fair as well as younger people with Covid-19. Here is another article that discusses the potential for melatonin in respiratory diseases. If you want to read the full article, you will have to click on the blue rectangular button that says "Download full-text PDF" once you follow this link :

researchgate.net/publicatio...

This very recent (March 20, 2020), brief and interesting link takes you to an opinion page where a doctor is discussing how melatonin might be used as adjunctive treatment for Covid-19 in patients with and without pneumonia and is relatively short and straight forward. He is advocating for use of melatonin "now" in Covid-19 patients. He feels that melatonin also would be an effective antiviral and antibacterial, but that is not yet known in Covid-19. This is worth reading!

devinenews.com/opinion-on-c...

The same doctor from the article just above, Dr. Richard L. Neel M.D., MPH., has actually

started treating Covid-19 patients with melatonin and vitamin C as the following link explains.I like what he is doing by practicing what he is preaching. His treated patient count is low at this point, but you have to start somewhere and a hospital seems a safe place to do that if you are already infected with Covid-19! A quick mention to the fact that there are a couple of ads at the 1/3 point and 2/3 point in the following article so please scroll past each ad to make sure you read the whole article, its interesting. This is a good read.

devinenews.com/dr-neel-trea...

One more update about Dr. Neel. He says he has treated 10 patients now giving them 80 mgs of melatonin per day. One of my supplement experiments involved taking 70 mgs of melatonin per day so I already have an idea of what 80 mgs will be like for me. Another good read and not long.

news4sanantonio.com/news/lo...

The following article highlights a lot of the known health benefits and effects in the human body of melatonin and then illustrates how these would apply toward treatment of Covid-19 patients and mentions that melatonin may go a long way in ameliorating or preventing the cytokine storm, pneumonia and damage to other organs. It is an easy read and is written in an easy to understand and follow way. Once you click on the link, it will show you the abstract and there will be a small rectangular blue button that says, "Download full-text PDF". Once you download the PDF, you can read the entire article for free. It's a good read!

researchgate.net/publicatio...

The following abstract suggests that the combination of Melatonin and Quercetin may help reduce inflammation related to hypoxia (oxygen deprivation to the tissues ) and modulate the measured parameters of the study to near normal levels, possibly helping to ameliorate or prevent the cytokine storm which has shown itself to be deadly in many people. Hypoxia can also cause damage to other organs that are starved of oxygen and this is seen in Covid-19 patients so it is very important in understanding the value of melatonin in Covid-19 patients!

ncbi.nlm.nih.gov/pubmed/282...

The following very recent article (March 2020) goes into greater detail on the role of melatonin as it relates to Covid-19, inflammation and pneumonia :

evolutamente.it/covid-19-pn...

Melatonin stops cytokine storms by inhibiting NLRP3 inflammasomes, reducing damage from pneumonia as result of A...

The following short abstract suggests that melatonin alleviates lung injury :

ncbi.nlm.nih.gov/pubmed/268...

The following article explains how Covid-19 can negatively affect the liver in a fairly high percentage of cases. Melatonin has shown itself to be a liver protectant.

the-hospitalist.org/hospita...

The following article discusses many facets of melatonin as it applies to Covid -19 and also discusses concomitant use with hydroxychloroquine as well as whether melatonin may preclude the need for mechanical ventilation and other relevant points. An important point that it covers is fibrosis as seen in the wake of Covid-19 and how melatonin may also ameliorate this growing problem. After reaching the abstract page, you will have to download the PDF by selecting the black rectangular button that says, "Download PDF" to read the entire article which gives some insight as to the multiple reasons why melatonin may be of great value in the treatment of Covid-19 patients.

preprints.org/manuscript/20...

The following article discusses a hospital in the Philippines that is using melatonin in their Covid-19 patients with apparently good results. They are using a lower dose than Dr. Neel with dosing in the 36 to 72 mg range. This may be because Filipinos are generally smaller people. Dr. Neel is using an 80 mg dose for the adults he has treated. The article is a little long and covers other topics related to Covid-19, but here is a quote from the article :

' One of the young cardiologists we’re mentoring texted me the good news about her father, a prominent physician in one of the teaching universities in the country, who has just been discharged after battling COVID-19. He was already about to be intubated and hooked to a breathing machine because all drugs given him didn’t seem to work and his pneumonia was getting worse. After three days on high-dose melatonin, he turned around, and nine days later, he was sent home.

We’re reporting our experience in a scientific journal, so hopefully, it could help save some COVID-19 patients, especially the elderly, who are reportedly left to die in some cities in Italy and Spain, so that doctors could allocate their resources to younger patients. If this information could save a few of these lives, it shall have been worth all that we’ve gone through convincing our local colleagues about it. '

Here is a link to that article:

lifestyle.inquirer.net/3610...

The following link discusses repurposing of existing drugs including melatonin. It is quite lengthy if you are pressed for time and don't have time to read it, here is a quote from the article :

nature.com/articles/s41421-...

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Inflammatory pathways play essential roles in viral infections56,57. As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59. Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60. The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients’ clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62. In addition, the application of melatonin may prolong patients’ survival time, which may provide a chance for patients’ immune systems to recover and eventually eradicate the virus. As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB. Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin. By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63.

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The following 2 links, while not related to Covid-19, takes you to two abstracts of a study where melatonin was used at a dose of 70 mg per day in children with Duchenne muscular dystrophy for 9 months to good effect. I'm adding this one just to show that melatonin is relatively safe in children who might get Covid-19, even at 70 mg/day. They used it everyday for 9 months, whereas it may only have to be used for a much shorter time period in Covid-19 patients.

ncbi.nlm.nih.gov/pubmed/202...

ncbi.nlm.nih.gov/pubmed/215...

The following link discusses the known side effects of melatonin.

mayoclinic.org/healthy-life...

I am not recommending melatonin, just putting the information out on the forum so anyone interested can discuss it with their doctor or health care professional and to also make sure it is compatible with everything you may be taking. I hope that you will be able to get enough information from this post to see that what Dr. Neel is suggesting is a non-invasive way to assist in the treatment of Covid-19 and possibly in the interim period where you might be told to stay home and rest and then go to the emergency room if you have trouble breathing. Remember, there are drugs which are working to various degrees, but will we be able to get them and how long will we have to wait before we are tested and accepted as a patient in the hospital to receive those treatments if they are available? If melatonin is as effective as Dr. Neel and the Philippines have seen so far, melatonin may be a consideration between you and your doctor during that period while you are waiting for your breathing to become difficult enough to be allowed into the hospital. If it works as they have seen so far, perhaps that trip to the hospital may never be needed! Dr. Neel is talking about positive effects in as little as one day.

Some of the drugs that are being tested for Covid-19 have significant side effects and judging by what is already known about melatonin, it may even help to ameliorate the severity of some of those effects while also helping to alleviate symptoms of the disease itself. His hope, as he mentioned is that melatonin may prevent a patient from ever needing to go on a ventilator in the first place. Given that some hospitals don't want to accept you in until you are having a hard time breathing, to me, if I feel I am getting sick in any way, I will continue to take the melatonin that I am already taking plus the difference to get up to his dosing schedule in the hope that I never even have to go to the hospital!

These are just more reasons why I refer to melatonin as one of my favorites! I would also like to mention that I recently restocked my melatonin supply and they came very quickly compared to my zinc picolinate order and my vitamin D and C orders! Since I have been taking melatonin for years, much of this is information about melatonin I was aware of and why I looked for a possible connection in the first place. I was not aware of its potential use as adjuvant treatment for Covid-19. Melatonin's ability to help protect the lungs and other major organs could be a very useful adjuvant treatment in trying to protect the body as a whole from most of the potential damage which Covid-19 has shown the ability to inflict on people infected with SARS CoV-2 and act as a potent antioxidant and also act as a potent antiinflammatory,all well known melatonin attributes and this is a very big thing for Covid-19 patients to help protect almost all of the organs that Covid-19 is now thought to involve in addition to the lungs. A drug that can safely destroy the virus is extremely important, but ameliorating or preventing the damage caused by the virus is important now and later for the patient!

I am sorry for the length of this post, but since melatonin has not previously been discussed for this purpose on this forum, I wanted to include as much relevant information as possible to give some background.

This post will be easy to search for if you ever want to draw on this information again by searching for "Melatonin" or you can click on my icon and select it from the few posts listed. I think there is also an option to "follow post" in which case you will be notified anytime the post is added to or replied to.

Art

157 Replies
oldestnewest

Interesting! Why is it some people can’t tolerate melatonin? I seem to be one of those people. I’ve tried it a few times to try to get a better sleep — It starts to make me feel sleepy but after a couple hours it makes me feel jittery and keeps me awake even more! I’m feel like I’m missing out on a great supplement.

chartist
chartist
in reply to Oceanflow

Yes, It is like many other supplements and drugs, some you can tolerate and some you can't, but if it only causes you to be jittery, that might mean that you can tolerate it long enough to be useful against Covid-19 . The doctor who is using it and the hospital in the Philippines who are using it on their C-19 patients are talking about a relatively short course.

Art

Thank you for the dedication you have given to helping us Art. I appreciate you very much.

Thank you very much, Ernie!

If the doctor and the hospital are correct about how Melatonin seems to be working against C-19, it takes some of the fear away to me of the idea that this virus may come back each year. It makes me feel like the at risk groups, may not be so at risk any more.

Art

ConnieD
ConnieD
in reply to chartist

Such great info Art! Thank you! 😊

chartist
chartist
in reply to ConnieD

Thank you, Connie! I hope it works out just as the hospital and Dr. Neel are finding!

Art

Gigi216
Gigi216
in reply to chartist

Yes I’ve been in a bit of a panic honestly so this information is so welcome!

chartist
chartist
in reply to Gigi216

Gigi,

What is good about this is that since melatonin is an over the counter supplement here in the US, doctors do not have to wait for trials and FDA approval if they opt to offer it to their patients and that will be a tremendous time saver. Dr. Neel is an example of this. He just chose to offer this option to his C-19 patients and did it with good results. I'm sure one of his main concerns was the safety of melatonin at that dose, but since he has studied melatonin for years, he was already aware of its safety profile. I'm really interested in how the hospital does because they said they are in the process of publishing their report on the use of melatonin for C-19!

Art

Gigi216
Gigi216
in reply to chartist

Yes wonderful news and I’m thankful smart men like him are willing to share their knowledge with everyone this will certainly save lives

chartist
chartist
in reply to Gigi216

I worry about the availability of any drug that proves out in their respective trials and ultimately gets FDA approval. Availability to the masses is going to be an issue. At least melatonin is available right now if doctors want to recommend it to their patients. It just seems like doctors should have something to offer you in that period where they will not accept you into the hospital until you have difficulty breathing. The period when you first show symptoms. It seems like melatonin would be ideal during that period before the disease gets a foothold.

Art

Gigi216
Gigi216
in reply to chartist

Yes I feel so badly for the people who didn’t make it and didn’t have access to information like this! This is a lifesaver! Yes who wants to wait around and get in critical condition

Please keep us posted on the hospital report if possible.

I am going to keep an eye out for that report from the hospital, Ernie and will post it if I find it.

Art

Thank you 😊

Awesome and extensive info! Thanks so much!

chartist
chartist
in reply to Gigi216

Thank You for saying so, Gigi!

Art

Thank you Art. This is valuable information. You are such a gifted man and very patient to go through all that information and post & send it (and understand it). Very much appreciated.

chartist
chartist
in reply to laglag

Thank you for that, laglag!

I really wanted to make it a much shorter post so more people would read it, because melatonin has not been previously discussed on this forum for Covid-19, I wanted to give more background information. Nothing right now has a ton of information when it comes to Covid-19, but data is being reported daily to update what is out there. Melatonin just happens to be one that has not been reported much and is definitely new for this purpose.

Art

laglag
laglag
in reply to chartist

Well, I will need to read your post from 2 months ago a little closer. My dad, who is in a nursing home, was just diagnosed yesterday with covid-19, he's asymptomatic but they still need to isolate him.

Have your thoughts or research changed any from 2 months ago? He had neck surgery about 7 months ago, he was in pretty bad shape but has worked hard to be able to walk with no assistance, except a walker, just getting ready to go back to assisted living. I would hate for him to have a setback. I read only 30% of asymptomatic end up never having symptoms. I pray he's one of the 30%.🙏😷

chartist
chartist
in reply to laglag

First, because he is asymptomatic and the testing is not close to 100% accurate, there is the slight possibility that he is a false positive. Dr. Costantini was tested 3 times and two were negative while one test was positive. If Dr. Neel is correct, the melatonin should help tremendously if he does develop symptoms, but will they allow you in to see him?

One change I see from two months ago is that it is now known melatonin can potentially deplete vitamin D and vitamin D can potentially deplete melatonin and it turns out the two are likely synergistic against Covid-19.

At last report, Dr. Neel has 20 or more patients and he reports that they are all doing well and some are down to a low maintenance dose of melatonin.

Art

Priceless! Thank you Art!

chartist
chartist
in reply to faridaro

Thank you very much for saying so, faridaro!

Art

Art, I may have missed it in your post, but is there a particular form of melatonin that is preferable, i.e., sublingual vs capsule?

chartist
chartist
in reply to rebtar

Dr. Neel only stated 80 mg in divided doses and that was it. They do make 20 mg capsules, but the 10 mg caps are generally less expensive. So that would be 2, ten milligram caps 4 times per day. I haven't checked the sublingual versions, but I don't think they make those in 20 mg and I am not sure about 10 mg sublinguals. The largest sublingual melatonin I have seen is only 5 mg and that would mean 4 pills per dose.I saw a quick dissolve 12 mg, but it didn't say it was sublingual and the directions did not say to place it under the tongue.

As far as the hospital in the Philippines, they gave their dose range as 36 to 72 mg per day in 4 divided doses. I don't think they want to give to much of their information right now because they mentioned that they are going to be putting their data into a scientific paper with an as yet unnamed journal.

Art

rebtar
rebtar
in reply to chartist

Thanks! For all of it!

chartist
chartist
in reply to rebtar

I found a quote from Dr. Neel where he answers your question.

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“I think this could help a lot of people a lot faster, and it has a great safety profile. Melatonin is sublingual so it will dissolve on the tongue, and that is another great thing about it.”

Art

Here's a 10mg sublingual Melatonin I've used: amazon.com/gp/product/B01E1...

I generally sleep very well when I take it! Based on some of the other replies on this thread, maybe I need to take it earlier in the evening.

Thanks for all the great info, Art!

Thomas

chartist
chartist
in reply to rebtar

I finally found out why Dr. Neel was using sublingual melatonin. It is because he was thinking that the sublingual form may work for a patient who is on a ventilator, but as far as I know he has not had to put any of his patients on a ventilator.

Art

AHA that makes sense.

Melatonin stopped the sun downing my husband was experiencing which was wonderful. I gave it to him at 4 pm (10 mgs;) or close to the sun going down.

I wish more doctors were like yours, where the doctor actually recommended melatonin for "sundowning" at the right time and right dose???

Art

I was the" doctor. " I am a retired RN, though .My husband ended up in the emergency room with hypothermia after laying outside all night in the dirt when he wandered off. It had gotten so bad we tried to lock him in his room but the even the cat who could open levered doors, let him out. As we were leaving the hospital, the emergency room doctor said," You want to keep him out of a home , he's more likely to start sun downing. there." I went home and looked up sun

downing and realized that's exactly what he was doing. I decided to start giving him 10 mg at 4pm and 6-10 mg at 10 pm.He had been on melatonin just at bed time. I don't think anyone has ever had a melatonin overdose.

He didn't sun down again (he died in February) except once, when my son was taking care of him and he got it late ,after the sun went down.

I remember your sundowning story, albeit incorrectly, but I did remember the earlier dose being the important aspect! I have seen nurses that are very impressive in their medical knowledge and it sounds like you could be one of those. I had a cousin who was a head nurse, and while she could be bossy at times, doctors were willing to listen to her ideas. She had been a nurse longer than some of the doctors were old, so I guess she picked up a lot of knowledge along the way! Thank you for the correction and for the sundowning information and melatonin that it seems like you may have posted about two months ago? It confirms what the studies show regarding sundowning and melatonin.

Art

Yes, I did post it several months ago, I thought it was very interesting that it worked. His sun downing was ruining our lives, I really thought he would have to go into a care home (at least $5000 a month here in California). I like medical stuff and enjoy sleuthing around for ways to "fix" things. Thanks for your compliments!

I still read the Health Unlocked to see if I can help others with what worked for me, from the Veilight 810, to drugs that worked for psychosis and hallucinations.

Thanks Arte, beautiful post. Thanks to this, in my family (Italy) we are very interested to use it. Do you have a product to recommend us?

chartist
chartist
in reply to Fed1000

Fed1000,

I've used different brands of melatonin and have never noticed a difference between brands, so I would use any brand.

Art

Fed1000
Fed1000
in reply to chartist

Hi Arte, I started Melatonin for a few days: 5 mg. in the morning and 5mg. the night before going to bed. The problem with Melatonin is that it makes me very tired and it becomes very complicated with physical activity. What do you think about that? Thanks Arte.

chartist
chartist
in reply to Fed1000

Generally speaking, I only take it at night, because that is when melatonin is naturally deployed by the body. Daylight diminishes melatonin production levels and as daylight turns to early evening, melatonin production and excretion by the pineal gland starts. Melatonin is supposed to make you sleepy and that is why I do not take it before 6 pm.

I mainly intend to use the high dose if I get Covid-19.

Art

Fed1000
Fed1000
in reply to chartist

Yes, I will try to exclude the morning dose and I will take 5mg before going to bed. As well as improving sleep quality, what other effects does Melatonin on Parkinson's disesase? Thank Arte

chartist
chartist
in reply to Fed1000

Fed1000,

You just want to open up a can worms!

This is what melatonin is likely to do in PD. First it up regulates the gene expression of the bodies own potent antioxidant system which includes Glutathione Peroxidase(GPx), Catalase (Cat), Superoxide Dismutase (SOD) and Glucose-6-Phosphate Dehydrogenase(G6PD).

Next it will act as a potent scavenger of multiple radicals such as Reactive Oxygen Species(ROS), hydroxyl radicals, Reactive Nitrogen Species (RNS), Peroxynitrite and Hydrogen Peroxide(H2O2).

It will cross the blood brain barrier(BBB) to neutralize radicals in the brain and lower inflammation. Both of these entities are known to be elevated in PD and cause damage to neurons. Melatonin can readily enter all tissues of the body including the brain.

A forum member posted in the last two weeks to say that they have been taking high dose melatonin (HDM) in place of meds and have had no apparent symptoms or progression for years, but unfortunately it does not seem to work this way for everyone and you also have to consider that some can not tolerate HDM.

Melatonin is known to be brain protective as well as protective of all major organs of the body including the heart which is sometimes compromised in PWP. As part of this protective process, melatonin is protective of endothelial cells which can also be damaged in cases such as atherosclerosis which is commonly seen in senior citizens. Melatonin can help to alleviate atherosclerosis through its potent antiinflammatory and antioxidative activities. Melatonin is a 5-Lipoxygenase inhibitor which is inflammatory.

Melatonin protects the mitochondria function through its potent antioxidant activities and increases the efficacy of mitochondrial electron transport chain and reduces electron leakage. Through its potent antioxidative actions, it prevents tissue damage and blocks transcriptional factors of proinflammatory cytokines. Melatonin can help to lower the chronic neuroinflammation and oxidative stress that is seen in PD and other neurodegenerative disorders.

Here is a link to a very brief abstract that outlines some of the actions of melatonin in the brain :

ncbi.nlm.nih.gov/pubmed/321...

There are quite a few studies now which suggest potential benefit from melatonin in neurodegenerative disorders including PD.

In more recent studies it is suggested that excess artificial lighting at night may be a pro-PD factor that can cause further damage to the substantia nigra. This same type of light pollution is known to also lower melatonin levels which are already in decline from puberty forward.

Current research is working on detection of melatonin in the brain using electromechanical methods which when improved should be able to accurately detect melatonin concentrations in many areas of the brain which will be highly useful in determining optimum dosing and its effects in the brain.

This last abstract gives an idea that melatonin is likely to be useful in multiple neurodegenerative disorders :

ncbi.nlm.nih.gov/pubmed/317...

Art

Fed1000
Fed1000
in reply to chartist

Hi Arte and thanks again. I don't know what it means to open a worm worm, the truth is that, thanks to your posts, I am increasingly interested in knowing the seems, from a lot of studies that I have read, more and more suitable for PWPs. There is talk of taking high doses of Melatonin to obtain good results (I refer to Parkinson's not to Covid19), which do you think could be an effective and tolerable dose? In Italy there are no products that exceed 3mg. otherwise you need a prescription. Arte excuse me if I still take advantage of your availability, I promise not to bother you for a long time. Best regards

chartist
chartist
in reply to Fed1000

Fed1000,

Sorry about that, it is a common US term. Here is what it means :

'Metaphorically speaking, to open a can of worms is to examine or attempt to solve some problem, only to inadvertently complicate it and create even more trouble. Literally speaking, opening a can of worms, as most fishermen can attest, can also mean more trouble than you bargained for.'

No problem with questions.😊

As far as taking melatonin for PD, "in theory", it looks like it could be useful, but actual human studies are lacking to give a definitive answer. A forum member recently posted something about taking 80 mg/day of melatonin and no meds with very good results as far as PD symptoms if I remember correctly, but they did not give a lot of details and I did not see a follow up post from that forum member. The post caught my attention because he/she happened to be taking 80 mg/day which is the same dose that Dr. Neel recommends and gives to his Covid-19 patients.

Art

Fed1000
Fed1000
in reply to chartist

For me they are unsustainable levels. All clear Arte. Thanks again. Best regards

chartist
chartist
in reply to Fed1000

For me it would be interesting to see how much melatonin you would have to take to reach childhood levels again.

Art

Fed1000
Fed1000
in reply to chartist

It would be fantastic, you would also get useful information for other pwps which could add melatonin to their options.

Amazing information, thank you for this. Think it’s on prescription only in U.K. but we have an amazing GP who is really supportive with my husbands treatment and is willing to listen and help with PD.

Listening as I type this to Professor Sarah Gilbert, a vaccinologist, from Oxford University who has a vaccine for Covid 19 starting trials at the moment in U.K. she’s saying it should be available by September! Please God.

chartist
chartist
in reply to Zella23

Zella23,

Great to know a vaccine is coming soon!

Art

Thanks Art. Lucky for me, I've been taking 10 mg a day for years. I will up my dose for a few months now.

Marc. See my reply to Art about anti-inflammatories. Richard

chartist
chartist
in reply to MBAnderson

Marc,

No wonder you look so young in your icon picture, it looks like it is working really well for you!!! 😜😜😜

MBAnderson
MBAnderson
in reply to chartist

ha

🤣🤣

This is an amazing amount of material and really interesting. Thank you so much! I feel it is very relevant to me as I have asthma which is not very well controlled and another inflammatory autoimmune condition as well as Parkinson’s, so I feel very at risk and will certainly be giving this a try. I have only read the first article so far. The only slight note of caution I can see is when the therapy should be started. The first paper seems to suggest using melatonin when the infection is more severe rather than the early stages (mouse model):

“There is probably a balance of the protective and damaging actions of NLRP3 in the lung. Thus, in a mouse experiment, inhibition of NLRP3 in the early phase of infection increased mortality, whereas suppression of NLRP3 at the peak of infection allowed for a protective effect [51]. This supports the use of melatonin in ALI/ARDS when inflammation is most severe.”

I don’t currently take melatonin and was just wondering if you have come across any information about timing, detailing when the best time to start this would be for those of us who are not presently taking melatonin?

For those on other medications, please check out side effects and interactions.

webmd.com/vitamins/ai/ingre...

Many thanks again Art!

LoveSunflowers,

In the articles below where you currently are, Dr. Neel is giving it to his patients as soon as they call and report symptoms to him. It sounds like he tests them and if they are positive he starts them right away on melatonin and he reports the beginning of improvement in 24 hours.

Art

Thank you so much for getting back to me. That’s great, It’s definitely worth a try! Thank you

LoveSunflowers,

Since you mentioned asthma, I thought you might find this very brief abstract of interest :

ncbi.nlm.nih.gov/pubmed/275...

Art

Great, thank you very much. 😊

This is very informative. I have just discovered that melatonin is only available on prescription in the uk so that is a bit of a problem.

Does anyone have any suggestions on what I can do about getting some melatonin?

Seamus6
Seamus6
in reply to M-o-ggy

I'm in UK. I got my GP to prescribe Melatonin, it helps somewhat with sleeping @4mg.

Rgds

P. S big thanks to Art for this post 👍

M-o-ggy
M-o-ggy
in reply to Seamus6

Thank you. Are you saying that you take 4mg a day?

Seamus6
Seamus6
in reply to M-o-ggy

Yep 4mg, not every night just now and again. Seemed to work really well when I first used it, not so much now. I might try 6.0mg

M-o-ggy
M-o-ggy
in reply to Seamus6

Thank you

Art

It's very long. I read to the end of COVID-19: Melatonin as a potential adjuvant treatment, which was speculation.

My caution (alarm?) is that Melatonin is an anti-inflammatory. Whilst it might be helpful in post-infection recovery, I am concerned about its use as a prophylactic and during infection. The body's natural response to infection is inflammation. Suppressing that inflammation weakens the body's resistance.

In France , the government has issued a warning about using ibuprofen (the most commonly available OTC NSAID) because it is linked to higher mortality in Covid 19 patients. In the UK patients with rheumatoid arthritis are required to self-isolate as a high risk group due to their anti-inflammatory medication.

Have you considered this?

Richard

Hi Richard,

When you get to the links below where you currently are, the doctor describes using it on his patients as soon as they report symptoms and test positive. He is hopeful that it reduces inflammation enough to prevent a cytokine storm and pneumonia. In one of the links it takes you to an article that describes where the virus goes once it is in the body and it pretty much is found throughout the body, but it is damaging the liver, lungs, kidneys and heart from what they have seen in autopsies of Covid-19 patients. I was not aware of just how much damage this virus is doing to the major organs and Dr. Neel is trying to prevent or ameliorate as much of that damage as possible by starting his patients as soon as symptoms appear and they test positive. He is reporting continued improvement after 24 hours on melatonin and that sounds similar to what the Philippine hospital is reporting in their patients.

Art

Bedankt Arte, zeer nuttige informatie.

Kimdur24591,

Herzlich willkommen!

You're welcome!

Art

Thanks, Art! You are an amazing person. Learned so much from you, and I am eternally grateful for your knowledge and compassion to help PwP.

The benefits of Melatonin are incredible! Let me add a link:

articles.mercola.com/sites/...

chartist
chartist
in reply to Despe

Interesting read, Despe!

I had read about the potential utility of HBOT in Covid-19, but the problem was that the chamber has to be thoroughly sanitized after each use and there is a problem for the worker who is transferring the patient to the chamber of increased risk of infection, so though HBOT has great potential for patients, that issue will need to be worked out.

As far as Dr. Fauci's predictions on cases, that will probably change even further if they open the economy backup and that will be even harder to estimate since Trump is putting the decision on individual governors. With that decision by Trump, it will be even harder to make any predictions, because nobody knows which governor will open back up and when. It would be my guess that as soon as individual states start to open, both the cases and the deaths will start to rise again. It may speed the herd immunity process up, but what good is herd immunity if the virus mutates extensively and the antibodies created by the initial infection are not effective against the new strain? In any case, it is senior citizens who are going to account for the majority of the increased death rate.

This article covers a lot of ground! The part discussing vitamin C and D as well as other supplements like zinc and selenium is useful, but many of those supplements are sold out until further notice. Melatonin is still available.

Art

Despe
Despe
in reply to chartist

So many X factors, Art, for the right approach and successful outcome! In the meanwhile, my husband and I stay home as much as we can and take precautionary measures when we go to the grocery store (our only entertainment now a days :( ) We also take vitamins/supplements/minerals, but most importantly we have not panicked and try to live our lives as normal as possible. We don't watch daily updates on TV either as they add to our already bad psychology. Figure if there is breaking news, we will hear about it.

Husband will start Ozone therapy on April 22 for PD not COVID-19. Guess with one stone two birds. :)

PS. Better order more Melatonin before it becomes unavailable, too.

chartist
chartist
in reply to Despe

Despe,

Yeah, lock down is boring isn't it!

I gave that melatonin post to a friend of mine who is going to put it up on her site so there may be a temporary demand for it, but it is not talked about the way that zinc, vitamin D and C are, so it should not be a problem. Let us know how the ozone therapy goes! What concerns me a lot is the way that C-19 goes after other major organs as outlined here :

washingtonpost.com/health/c...

Hopefully melatonin will be effective in stopping or limiting that damage!

Art

I found this article on melatonin being both inflammatory and anti-inflammatory in different moments of disease or different situations. Admittedly I didn’t understand it all, but if those of you who are more scientifically inclined find it useful, please share what you find.

onlinelibrary.wiley.com/doi...

In the main post above, I mentioned that melatonin declines with age and in one of the links in the post is a graph which clearly illustrates this. This may be a very important point because it can potentially explain 4 things about melatonin and Covid-19. 1. Is that it can possibly explain why young children seem to be resistant to catching C-19 and two, it may explain why the oldest are much more susceptible to catching and being killed by C-19, 3, why bats which are considered to be a likely source of SARS CoV-2 are not apparently affected by it and 4, why Dr. Neel and the hospital in the Philippines are having success giving it to their C-19 patients.

Bats have much higher levels of melatonin (up to 500 pg/ml) which may protect them, senior citizens contain way less melatonin (15 pg/ml) than young children ( up to 125 pg/ml) as the graph link below will clearly illustrate.

evolutamente.it/wp-content/...

Art

chartist
chartist
in reply to MBAnderson

It's already in the post, Marc, but the post is so long it takes a little looking!😉

Art

This quote from the following study may be of interest to those who are concerned about any potential negative effects from Hydroxychloroquine or Chloroquine.

' At the same time, even the research on the anti-malaria effect of melatonin antagonists noticed that high doses of melatonin are beneficial for malaria treatment because they inhibit programmed cell death and oxidative stress. Thus, applying melatonin as an adjuvant to chloroquine and hydroxychloroquine treatments of Covid-19 may reduce the necessary doses, and thus toxicity, of these agents. '

researchgate.net/publicatio...

Art

Here is another recent article showing that melatonin is likely to be helpful in the treatment of Covid-19 and it goes on to describe how melatonin can reduce the chance of or diminish any potential cytokine storm! Further it goes on to discuss how melatonin may be useful for many other deadly infectious viruses in limiting the damage they may cause while buying time for the body to mount a strong, but controlled immune response to kill the virus itself and likely generating many antibodies to the virus along the way. This tends to confirm what Dr. Neel is seeing in his C-19/melatonin patients that in just one day he is seeing noticeably reduced symptomatology in his patients. This is likely what they are describing in saying that melatonin can attenuate symptoms to a manageable and safer level, allowing the body to mount a safer and measured response instead of a cytokine storm which has shown itself to be deadly in some patients.

Overall, the article is long, but informative and does tend to confirm what Dr. Neel is seeing in his C-19/melatonin patients! It tends to show that melatonin can be a gentle way to help the body to do what it is supposed to do in terms of dealing with C-19 and other similar viruses.

melatonin-research.net/inde...

Art

Gigi216
Gigi216
in reply to chartist

I feel with this information I can finally take a breath. I’ve been under such stress like everyone is about this virus. We all worry about our loved ones and ourselves and this is lifesaving and I’m very grateful

chartist
chartist
in reply to Gigi216

Gigi,

Thank you for saying so! Stress is not good for us!

I was thinking about Dr. Neel and his background in determining counter measures for biological weapons. That job is what got him to find melatonin and his knowledge of melatonin is what got him to think of using it for Covid-19! Without that previous training, he may never had even considered melatonin for C-19!

Art

Gigi216
Gigi216
in reply to chartist

I was thinking the same thing! He knows what he’s talking about!

chartist
chartist
in reply to Gigi216

Here is an important quote from the article link.

' For the hosts, melatonin improves the defense system by upregulating the expression of antioxidant enzymes such as SOD, CAT, and glutathione peroxidase(163), effects that reduce the oxidative tissue damage caused by the pathogens. Most importantly, melatonin redirects the host immune response, i.e., by controlling the potentially over reactive innate response and promoting the adaptive immune response. ' (as in less chance of the potentially deadly cytokine storm)

melatonin-research.net/inde...

Art

Gigi216
Gigi216
in reply to chartist

You know I think experts are freely sharing what they know because they realize the stakes for humanity I’ve never seen the scientific community and medical community come together like this, they want to save as many as they can. Bless them for letting us know and bless you for bringing to everyone here

Hi Art,

Speaking of anti-inflammatories, here is something that was recently discovered here in Italy by an authoritative cardiologist: “In a period in which the news overlap and hope is placed deep in the heart of all of us, in the Coronavirus emergency we have sought to avoid both alarmism and news that were not linked to a reality at least concrete. We report a news that has been circulating for a couple of days on social media and that to us, despite the delicacy of the moment, it seemed appropriate to read it with the utmost caution. (The editorial staff).

Bologna - From social media comes good news about the Coronavirus, perhaps a solution, which has scientific foundations and is spread by an authoritative doctor from Rizzoli of Bologna, Sandro Giannini. His is a highly qualified curriculum: Full Professor of Orthopedics and Traumatology and of Physical Medicine at the University of Bologna since 1989, director of Clinic I at the Rizzoli Orthopedic Institute and of the Gait Analysis Laboratory, partner in European projects and in national and international research programs, author of more than 600 presentations at national and international conferences and more than 400 articles in Science Citation Index journals. His message gives great hope. Let's read:

“I don't want to seem overwhelming to you, but I think I've demonstrated the cause of coronavirus lethality. Only at Blessed Matthew are there 2 cardiologists who turn over 150 beds to do echocardium with enormous effort and one is me. Terrible fatigue! However, of what some supposed, but could not be sure, we now have the first data. People go to resuscitation for generalized venous thromboembolism, especially pulmonary. If this were the case, resuscitations and intubations are of no use because first of all you have to dissolve, or rather prevent these thromboembolisms. If you ventilate a lung where blood does not reach, it is not needed! In fact 9 out of 10 die. Because the problem is cardiovascular, not respiratory! It is venous microthrombosis, not pneumonia that determines fatality!

And why are thrombi formed? Because inflammation, as per school text, induces thrombosis through a complex but well-known pathophysiological mechanism. Then? Contrary to what scientific literature, especially Chinese, said until mid-March, it was that anti-inflammatories should not be used. Now in Italy anti-inflammatories and antibiotics are used (as in the influences) and the number of inpatients collapses. Many deaths, even 40 years old, had a history of high fever for 10-15 days that was not treated properly. Here inflammation has destroyed everything and prepared the ground for thrombi formation. Because the main problem is not the virus, but the immune reaction that destroys the cells where the virus enters. In fact, our COVID departments have never entered patients with rheumatoid arthritis! Because they make cortisone, a powerful anti-inflammatory!

Therefore, hospitalizations in Italy are decreasing and it is becoming a disease that is treated at home. By taking care of it well at home, you avoid not only hospitalization, but also the thrombotic risk. It was not easy to understand it because the signs of microembolism have faded, even at the echocardium. But this weekend I compared the data of the first 50 patients between those who breathe badly and those who don't and the situation appeared very clear. For me you can go back to playing and reopen the business. Quarantine street. Not now. But time to publish this data. Vaccine can arrive calmly. In America and other states that follow the scientific literature that calls for NOT to use anti-inflammatories is a disaster! Worse than in Italy. And they are old and cheap drugs. "

mesagne.net/cronaca/12133-c...

Gigi216
Gigi216
in reply to GioCas

So you are saying it should be fine to use NSAIDS? And probably needed? Thank you so much for this information!

GioCas
GioCas
in reply to Gigi216

Hi Gigi,

Nonsteroidal anti-inflammatory drugs (NSAIDs)

I do not, I have only cited a study which, if confirmed, seems interesting for the most serious cases which, if canceled by a cure, would give another aspect to this disease.

Gigi216
Gigi216
in reply to GioCas

Ok thank you for clarifying! I will probably incorporate some anti inflammatory herbs that may help

chartist
chartist
in reply to Gigi216

Nsaids are generally used to lower fever, but there is some evidence to show the benefit of the fever in helping to defeat the virus. So if the fever is mild, nsaids may not be needed. If the fever is high you should be in the hospital and the doctor may choose another method to lower the fever or not.

I remember when I was a kid and my mom always put a cold cloth on my head to help keep my head cool during the fever. Aspirin was more of a last resort if the fever was too high. Fever is a natural mechanism to help fight some pathogens, so it has a purpose.

Fortunately melatonin seems to help in respect to fevers. Here is a quote from Dr. Neel about one of his patients :

“The third patient who began treatment last Thursday, April 9th, has no more fever or body aches, and only a slight cough left,” Dr. Neel said.

Art

Gigi216
Gigi216
in reply to chartist

Yes I read that too! Boy you came across such a find with the melatonin!

That is really great information, Gio!

I never really understood why there was the period of not recommending anti inflammatories. They knew early on that the potent IL-6 inhibitor, Tocilizumab/Actemra would likely be useful to stifle the cytokine storm and it does, as does melatonin apparently.

Melatonin seems to modulate the immune system to not be as reactive to the virus and instead allows the immune system to mount a more controlled and productive response in a timely manner while significantly reducing symptoms for the patient. Melatonin is well know for its antiinflammatory qualities as well as its potent antioxidative abilities which are both needed in order to minimize viral damage to the human organism. Dr. Neel is reporting that melatonin takes to that roll very quickly in his Covid-19 patients. Melatonin looks likely to help establish herd immunity with less deaths as it seems to effectively limit the possibility of a cytokine storm, pneumonia and intubation/ventilation, the three things about Covid-19 that have sometimes led to death.

I know it is early days and not enough experience with melatonin in patients yet, but if it continues to show the benefit that Dr. Neel has reported, perhaps it will offer a way to more safely open the economy back up and offer a means for the at risk groups to survive any potential attack from Covid-19? More time and testing will be needed to know for sure, but this is the case for everything that is being tried on the virus right now, but melatonin does seem to offer a glimmer of hope so far.

Doctors can suggest melatonin to their patients now if they choose to as the current options seem less than optimal. Hopefully since Dr. Neel is just west of San Antonio, other local doctors will take his lead and start using melatonin on their Covid-19 patients given the good safety profile of melatonin.

Art

A basic update on Dr. Neel suggests other doctors are now considering use of high dose melatonin(HDM) for their Covid-19 patients and one Florida doctor who started a Covid-19 patient on HDM with initial good results!

devinenews.com/idea-of-usin...

Art

parkie13
parkie13
in reply to chartist

Hi Art, can you outline the basic dosages of melatonin and vitamin C that doctor Neel is talking about. Thank you

chartist
chartist
in reply to parkie13

Hi, Mary,

For adults, he is using 80 mg per day in 4 divided doses of 20 mg each dose. For vitamin C, I don't think he has stated the dose. I had a feeling that the use of vitamin C was based on the possibility that one of his first patients was already taking it so he had them just continue since vitamin C is likely to have synergy with melatonin just as quercetin does!

In the Doctors Hospital in the Philippines who is also using melatonin, they are not using any vitamins, just melatonin by itself or melatonin with Tocilizumab which is a very potent IL-6 inhibitor used for arthritis and to help fight a cytokine storm, but melatonin does that on its own and more!

Art

parkie13
parkie13
in reply to chartist

Thank you. From what I have been reading is that hydroxychloroquine is working also. It's working better with zinc added to it and the dosage isn't the highest dosage. Also they do add z-pack to it, but some of them did not add z pack. Mary

chartist
chartist
in reply to parkie13

Mary, for some of the best information on hydroxychloroquine that is up to date as of a couple of days ago, I added a MedCram video to my covid-19 information post yesterday, that gives, at least to me, an unbiased opinion of how it has done in various trials. Here is a link, it is the very last post in the thread and it is the bottom video :

healthunlocked.com/parkinso...

It seems there are issues with some of the trial designs and I'm not sure if the trial that rescuema has discussed was mentioned in his discussion, but he does discuss the other post that is up on the forum where it said it hurt more than it helped and again this could be at least partially due to poor trial design.

Art

Dr. Neel is recommending adult patients take 80 mg of melatonin every 24 hours and has seen improvement in each of his patients in just 24 hours with a reduction in symptoms. Since that is his suggestion and it is my intention to use melatonin if I were to get Covid-19, assuming I have not already had it, I tried taking 80 mgs last night in 4 divided doses. I took 20 mgs at 7:00 pm, 20 mg at 8:30 pm, 20 mg at 10 pm and 20 mg at 11:30 pm. I woke up this morning expecting the "melatonin hangover" that I initially felt in a previous months long test of melatonin at 70 mg, but to my surprise, there was no melatonin hangover! I actually felt quite rested and not sluggish at all! I did not include vitamin C even though he has mentioned its use with the melatonin because in the Doctor's Hospital trial of melatonin, they didn't use vitamin C and they got rapid results with melatonin, so I just thought I would keep it simple for now. Well that and my vitamin C order has not arrived yet!

To be fair, I do take 30 mg of melatonin a night in 3 divided doses as what I have previously described as melatonin 123, almost every night, so I'm sure that is a contributing factor to why going from 30 mg to 80 mg didn't produce the hangover or have any other obvious effect on me. So now I know that 80 mg / day of melatonin should not be a problem for me and again I reiterate that I am not recommending that anyone else do what I am doing, I am only describing my own experience. If anyone chooses to utilize Dr. Neels melatonin protocol it should be done under a doctor's supervision in order to be safe and make sure melatonin is compatible with everything you are taking.

I have an idea (speculation at this time) about melatonin and Covid-19 that is based on the available literature about melatonin and Dr. Neel's results in his small group of patients as well as the little information that the Doctors Hospital in Manila has shared so far. I think that melatonin may alter the immune environment in such a way that the virus can not cause a cytokine storm or allow pneumonia to get started because melatonin's potent reactive oxygen species scavenging abilities as well as its reactive nitrogen species scavenging abilities in conjunction with its potent antiinflammatory qualities including inhibition of IL-6 and other inflammatory mediators and inhibition of lung inflammation by way of modulated expression of Apelin 13 as well as inhibition of NLRP3 inflammasome, very effectively seems to reduce lung inflammation and damage to a level that is no longer dangerous and it does it very quickly based on Dr. Neels results. In the Philippines, it even seems to work fast and well with patients who already have pneumonia.

Three main things attributed to Covid-19 that has shown the ability to kill patients are severe Covid-19 induced pneumonia, the now famous cytokine storm and the addition of a ventilator. Melatonin seems to be able to prevent or ameliorate the first two items which automatically ends the need for a ventilator! Melatonin is also protective of all major organs which is important since autopsies are showing liver, lung, kidneys and heart damage that is attributed to Covid-19. Viral particles are also found in the brain, so it is felt that it is possible that Covid-19 could also cause damage to the brain if not checked early enough.

So if you eliminate or greatly limit the 3 ways that Covid-19 has shown the ability to kill patients, then how much of a threat is Covid-19 once melatonin is introduced? My speculative answer to that question is very minimal. All of these actions of melatonin that work contrary to the normal disease process can allow the body to do what it is naturally supposed to do, destroy invaders to the system which in this case is the SARS CoV-2 virus. The body can now defend itself without the deadly cytokine storm, against the now marginalized virus. This is what studies suggest as possible and what Dr. Neel is showing in his patients which means that the studies tend to confirm Dr. Neels results and those results tend to confirm the studies.

Given the above, melatonin seems to convert the killer virus into something that is not deadly at all. If the virus mutates as it has already with the known A strain, B strain and C strains that are already seen in different areas, there is a chance that by the time a vaccine is developed it may not be effective against the current strain if that strain has mutated extensively. These mutations have occurred fairly quickly suggesting that extensive mutation is a very real prospect when it comes to SARS CoV-2. Whereas the known actions of melatonin are likely to be able to deal with mutations of this virus.

It will take further testing of melatonin against SARS CoV-2 in Covid-19 patients to take this from speculation to fact, but if Dr. Neel's patient base continues to grow and other doctors take his lead as it appears may be likely, then that point of clarification and understanding may not be far away at all. Melatonin is showing the potential, via its ability to control and reverse the ability of Covid-19 to be so destructive within the human body, to actually take many people in the "at risk groups"off of that list! So this could make the virus more of a nuisance than a killer!

Melatonin may actually be the answer to safely controlling the virus while allowing the economy to open again because it makes the virus tolerable to humans with minimal to no deleterious effects. Yes, people will still get infected, but melatonin appears to make such infection "livable" while allowing the body to make plenty of antibodies against SARS CoV-2. Still speculation at this point, but continued positive reports on melatonin can potentially turn speculation to reality!

My other thought is, how many other practical choices do we have with what is currently known and available?

Art

chartist
chartist
in reply to chartist

I decided to try another evening of melatonin at 80 mg as I did in the post just above.

What I noticed is that once again I slept through the night and woke up a little earlier than normal, but once again, I felt well rested. I really don't notice anything different than usual, so, so far it is a good test. I may do one more night of melatonin testing at 80 mg.

Art

chartist
chartist
in reply to chartist

So I ended up doing three evenings of melatonin at 80 mgs per evening in four 20 mg doses per night and it seems I was able to tolerate it with no apparent problems. I didn't really notice anything while taking it except that a cough I have had since the first week of February after catching a Flu/cold the day after Superbowl, that is a choking cough when I would talk and would seem to worsen each day starting in the early evening, but more recently was starting first thing in the morning and worsening as the day went on. I was considering trying a lot of things on it, but I didn't because I figured it would just go away on its own, but I should have known better because I have had a cough like this at least five times in my life and each time it took 6 months to a year to go away on its own. It is different than the productive coughs I have had because this one is like a spasm when I talk, so I found that I kept talking softer and softer so I wouldn't get the spasm and cough to try and relieve the cough. There was no apparent phlegm at all once the cold was gone.

Well I am very happy to say that it appears that cough is now just a bad memory! The day after my melatonin experiment, I thought the cough might be gone, but now I know it's gone and I can talk at normal level again! Okay, I've always referred to melatonin as one of my favorite supplements, but it just went up a notch for me!

That flu, in hindsight, had quite a few aspects that are considered Covid-19 symptoms, but at the time, February third, I was not aware of Covid-19 so I didn't really give it much thought then. Now I realize I had a sore throat for 3 to 4 days accompanied by fatigue, headache, bodyache and fever which I didn't bother measuring and that was followed with a cold and in total it took me a month to get over everything except that horrible nagging cough! I hope eventually that my doctor can do an antibody test to determine if it was Covid-19.

That's the update for today!

Art

That is something definitely to keep in mind. Thank you hopefully none of us are going to need to try that.

Mary,

It sounds like the plan is to start opening the economy soon, at least on a state by state basis. If that happens this soon, the case rate will start to rise rapidly again and the death rate will continue to climb, melatonin may be the solution to the problems as I mentioned above. To be straight forward, we may not have a choice! Although apparently some government officials feel that seniors are expendable, to that I say, "over my dead body"!

Art

parkie13
parkie13
in reply to chartist

I have upped my vitamin D, vitamin A, iodine drops, and of course I've been taking magnesium for quite a while. I am also taking baking soda once in awhile and I do take only 5 mg of melatonin at night. I do have a nebulizer, that I have never used, and I do have hydrogen peroxide. I have one n95 mask, that I've been using when I go out. Well, it's going to be interesting. Mary

chartist
chartist
in reply to parkie13

Mary, you sound like you are prepared as you can be within reason!

Art

parkie13
parkie13
in reply to chartist

I wish it was true. But taking unpredictability of covid-19 I kind of doubt it.

Gigi216
Gigi216
in reply to chartist

My husband has been working the whole time he is considered essential at his place of employment he just has to work with one other person and a couple of security guards but it has still been nerve wracking

chartist
chartist
in reply to Gigi216

It's good that he is able to work in a relatively safe environment! I feel bad for the people who are unable to work, but need to in order to pay their bills!

Art

Gigi216
Gigi216
in reply to chartist

Yes my son in law works at same place and he has been layed off luckily my daughter works from home teaching Chinese children English so they aren’t doing too badly and of course we help them out

chartist
chartist
in reply to Gigi216

That's what parents do, take care of their children, even when they're not children any more!

Art

Yes, I got a feeling we're going to be doing over, after the number of cases climbs. It could have been so much different, if only we had PPE and the test from the beginning. So far, we see no Rhyme or Reason to this virus. So many people escape it unscathed and so many people have such horrible, debilitating conditions. Mary

chartist
chartist
in reply to parkie13

Mary, my feeling is that melatonin can allow a safer reopening of the economy while affording protection for the at risk groups and saving an endless number of lives.

Art

parkie13
parkie13
in reply to chartist

Except, how do we spread the message?

chartist
chartist
in reply to parkie13

A friend of mine owns a health discussion site and she put it up there and I am trying to get a lady who has a fairly good size audience for her podcasts, but she hasn't responded so I will just have to keep trying wherever I think it can help!

Art

parkie13
parkie13
in reply to chartist

ijr.org/massive-wisconsin-p...

Here is the latest from Wisconsin, a protest to be able to go back to work, right now.

chartist
chartist
in reply to parkie13

It's a tough choice when you are living from paycheck to paycheck. Do you stay home and lose what you have and possibly become homeless or do you go back to work and risk getting sick and possibly dying? Tough choices to be sure!

Art

I skimmed over this post once again and it is definitely worth a second look. Thanks again Art!

Thank you, Ernie!

I've tried to keep up with as much information about Covid-19 as possible and from everything I have read to date, it looks like melatonin is one of the best things I have seen in terms of treatment results, practicality, cost, availability, comprehensiveness of treating symptoms, safety and if done at the first symptoms with a confirmed positive test is showing the capability to reverse the disease process quickly! It does not destroy the virus directly, but rather modulates the bodies response to SARS CoV-2 by multiple methods and pathways including significant reduction of lung inflammation and oxidation which seems to put the potential for the sometimes deadly cytokine storm in check. It seems to work well at preventing, reversing or ameliorating Covid-19 pneumonia. These two actions of melatonin means that a ventilator may never be needed. Those are the three things that are associated with death from C-19. I feel that the elimination or alleviation of those three things makes C-19 a much different disease that the body should be able to destroy on its own with a more controlled and appropriate immune response and antibody production, exactly as it should. These actions of melatonin may negate the need for an antiviral medication that is likely to have potential for significant side effects.

Another benefit of melatonin is that it is also working to prevent damage to the organs that C-19 has shown in autopsies to also attack such as the heart, kidneys, liver and lungs and possibly even the brain!

If you were looking for a perfect drug to treat Covid-19, melatonin seems to check most of the boxes and will not require lengthy studies or government approval before it can be implemented! It only requires doctors who are willing to offer it to their Covid-19 patients the same way that Dr. Neel is doing.

Melatonin could offer a safer way to open the economy back up, because once that happens, increased cases of infection and death will occur, but melatonin seems to offer a way to treat those new infections in a safe and rapid manner which is likely to take a huge bite out of any death toll.

Art

There are a few excellent sources of naturally occuring melatonin in foods:

Fruits and vegetables (tart cherries, corn, asparagus, tomatoes, pomegranate, olives, grapes, broccoli, cucumber)

Grai ns (rice, barley, rolled oats)

Nuts and Seeds (walnuts, peanuts, sunflower seeds, mustard seeds, flaxseed)

Based on today's MedCram video, there is a lot of C-19 related damage to cells throughout the body including endothelial damage plus blood clotting which is resulting in hyper elevated levels of reactive oxygen species and inflammation and ultimately stroke or heart attack in C-19 patients of relatively young age who may also be symptomless right up to the stroke or heart attack.

Among all of the things that melatonin is known for, increaser of the bodies own potent antioxidant system , oxidant neutralization and radical scavenging, cardiovascular protectant, antiinflammatory, anti-clotting/anticoagulating, anti-ARDS activity, anti-ALI activity, endothelial protectant and blood thinning are part of its healthful effects. Imo this video adds to the case for melatonin in multiple ways to help ameliorate many of these viral related activities that are resulting in stroke and heart attacks in the relatively young, sometimes before any symptoms are apparent!

His comments on hydroxychloroquine did not sound very promising.

Art


This really different MedCram video from yesterday pointed out something that has been mentioned about Covid-19 that is unusual and that is the fact that more men seem to get the disease than women. They don't offer a reason for this difference, but they do point out that in the context of the video, 60% of the patients were men and 40% of the patients were women. Just speculation on my part, but I think it is worth noting that women seem to have significantly higher melatonin levels than men as outlined in this study :

ncbi.nlm.nih.gov/pmc/articl...

Here is a link to the MedCram video that highlighted this difference:


Art

I read something about this, I don’t remember where. Said that the double X chromosomes that women have has something to do with it. That much of the immune related genes are in the X chromosomes.

chartist
chartist
in reply to rebtar

More things are pointing at the idea that higher melatonin levels are associated with diminished viral infectiveness and severity!

1. Bats are known to carry these viruses yet don't seem to be affected by them. Bats have approximately 4 times the melatonin levels of young children.

2. Melatonin level seems to peak around age 4 to 6 and this group of children seems to be almost unaffected by the virus.

3. Seniors over 65 are clearly more prone to getting the virus and having the poorest outcomes. Their melatonin levels are almost nil with the sharp decline in melatonin seen at almost any time point after puberty.

4. Dr. Neel is having very positive results in just one day of giving his Covid-19 patients high dose melatonin (HDM).

5. Women appear to be less likely than men to get Covid-19 and women have significantly higher levels of melatonin than men.

6. Night shift workers are thought to have lower melatonin levels. It would be interesting to see how that group is fairing against Covid-19 compared to similar daytime workers.

Another stat that would be very interesting under the circumstances, is the melatonin level of every patient to see if there is any correlation between melatonin level and disease outcome.

Art

In yesterday's MedCram video (62) as well as today's video (63), Dr. Seheult goes into greater detail about the damage being done to the endothelium as well as the effects of this damage at same and downstream points, one of which is the reduction of Angiotensin 1,7 and the runaway oxidation that ensues. Today's video goes into more detail about the downstream effects of the damage to the endothelium as well as the massive generation of ROS.

Melatonin is also a signaling molecule that upregulates gene expression of antioxidant enzymes while itself being a potent ROS, RNS and hydroxyl radical scavenger while having antiinflammatory effects when systemic inflammation becomes elevated. Melatonin has shown itself to be a protector of the endothelium which this video shows is damaged as part of the disease process resulting in downstream damage in this cascade of events. Melatonin also helps prevent reduction of Angiotensin 1,7 which would be useful in diminishing disease progression. Dr. Seheult describes how Covid-19 greatly reduces angiotensin 1,7. If that isn't enough, melatonin is also an inhibitor of NADPH Oxidase!

This video series is continuing to show how melatonin has shown many pathways by which it can negatively impact the disease process of Covid-19.

Dr. Seheult and MedCram are generating a very lengthy list about known aspects of the method of action of this disease. What would make a great video at this point is one that compares their list to the known activities of melatonin! MELATONIN VS COVID-19!



Art

I've done more digging to get a better idea of what exactly melatonin may be doing to help Covid-19 patients and I am using Dr. Seheults video series to point me in the right directions to get a better understanding of what C-19 is doing in the body, especially in light of the fairly recent news that it is causing heart attack and stroke in younger patients who appear to be asymptomatic.

Covid-19 appears to affect almost every major organ of the body such as the heart, lungs, kidneys, liver and skin!

Given what is currently known about the virus, it is easier to see the utility of melatonin in trying to ameliorate the negative effects on the body of Covid-19, of which there are many.

Here is a compilation of anti-Covid-19 effects that melatonin potentially delivers against the virus in the human body.

Art

-------

Ways Melatonin Can Fight Viruses Including SARS CoV-2

The following items would be of great use in trying to effectively neutralize many of the adverse effects caused by Covid-19 in humans and are known effects of melatonin as well illustrated in the literature.

1. Melatonin has a potent anti-inflammatory action, especially in the lungs. Melatonin has shown the ability to break the ROS/inflammation vicious cycle.

2. Melatonin is a potent scavenger of many radicals, including reactive oxygen species(ROS), reactive nitrogen species(RNS), hydroxyl radicals, hydrogen peroxide and peroxynitrite.

3. Melatonin is a protector of major organs, including heart, lungs, liver, kidneys, skin and brain that are now known to be injured or damaged by Covid-19. Melatonin or its metabolites can cross the blood-brain barrier(BBB).

4. Melatonin upregulates gene expression of the body's potent antioxidants such as superoxide dismutase(SOD), glutathione peroxidase(GPx), catalase, and glucose-6-phosphate dehydrogenase (G6PD). These can all go a long way in improving the damage induced by Covid-19.

5. Melatonin protects the mitochondria function through its potent antioxidant activities and increases the efficacy of mitochondrial electron transport chain and reduces electron leakage. Through its potent antioxidative actions, it prevents tissue damage and blocks transcriptional factors of proinflammatory cytokines. These are all crucial points relating to Covid-19 and the damage it is known to cause.

6. Melatonin reduces free radical damage to DNA. Melatonin receptors are found throughout the body suggesting that the body has many uses for it.

7. Melatonin is an inhibitor of NADPH Oxidase, which becomes significantly elevated in Covid-19 patients and can do very significant damage to the epithelium via elevated superoxide level if left unchecked as outlined in the MedCram video series.

8. Melatonin and its metabolites are neuroprotectant and can cross the BBB, which is vital since Covid-19 is known to enter the brain and do damage.

9. Melatonin is an endothelial protectant, which is important because Covid-19 is now known to damage the endothelium, which is a significant part of a cascade of damage that Covid-19 leaves in its wake.

10. Melatonin exerts a direct antioxidant effect on tissues/organs and antiapoptotic effects on cells. Melatonin inhibits neutrophil activation and reduces the damage they cause to endothelial cells, which is thought to occur in Covid-19 patients.

11. Melatonin can improve sleep, which can be crucial in keeping the immune system in good operating order.

12. Melatonin increases very significantly from birth to around age 4 to 7 years (a specific age group that seems very resistant to Covid-19) and then declines slightly until puberty, at which point its production and secretion by the pineal gland reduces sharply by age 60/65.

From that point on, melatonin levels are negligible. This 65+ age group with the lowest melatonin levels is also the group that seems to be most susceptible to the adverse health effects of Covid-19.

Obviously, with age, in general, comes multiple health issues that can account for part of the problem. Still, you can see where a lack of melatonin could be an additional factor that can be resolved through appropriate supplementation of melatonin. Add in the fact that many pre-existing conditions have shown to lower native melatonin levels in this already higher risk group and melatonin starts to take on even more significance for this high risk group.

Melatonin Graph

- Sorry, the graph would not copy into this post.

13. Melatonin in bats is approximately four times that found in humans at its highest levels for each. Bats are believed to be carriers of SARS CoV-2, yet bats seem unaffected by the virus. Is melatonin a contributing factor for this feature of bats? Melatonin may be causing the more controlled innate immune response seen in bats, but this is as yet not proven that melatonin is the reason for this process in bats.

14. Melatonin in women is generally at significantly higher levels than men. In the study that Dr. Seheult refers to in one of his videos, he mentions that out of the 100% of patients admitted to the hospital for Covid-19, 60% were men, and 40% were women. Could the significant difference in melatonin levels be a contributing factor to this phenomenon? Another possible contributing factor is that women are thought to have more ACE-2 than men. The virus can exhaust or destroy ACE-2 once it binds or docks to it to manufacture more viruses. Since melatonin has shown that it can increase ACE-2, is the higher melatonin in women the reason that they are thought to have more ACE-2?

15. Melatonin is released in the blood and can penetrate all body tissues, which suggests it can probably get to every place that the virus does within the body. Melatonin and Catalase reduce the cytotoxicity of Neutrophils in a dose dependent manner and this is important because this is a potential reason for the Endothelial damage that is likely occurring in Covid-19 patients. Melatonin upregulates gene expression of Catalase.

16. Melatonin can down-regulate the innate immunity overreaction response to SARS CoV-2, limiting the potential for the cytokine storm that has been seen in Covid-19 patients and has resulted in death. While doing this, it is promoting the adaptive immune response, which can aid in the production of antibodies to SARS CoV-2.

17. Melatonin at higher dosing, such as used by Dr. Neel, can downregulate NLRP3 inflammasome activation to help protect the lungs. The anti-inflammatory effect of melatonin can be enhanced by higher-dose vitamin C, just as Dr. Neel is using in his Covid-19 patients. Quercetin is also likely to have synergy with melatonin in terms of being anti-inflammatory. On the other hand, high dose vitamin D (4,300 IU+/day) reduces melatonin production. Bats have little vitamin D. Vitamin C is useful and likely synergistic with melatonin, but pales in comparison to the potential broad ranging utility of melatonin in Covid-19 patients.

18. Melatonin acts to ameliorate atherosclerosis through inflammation reduction, radical scavenging and mitophagy activation. Covid-19 may rapidly add to existing atherosclerosis and contribute to these vascular complications seen in patients with Covid-19. Melatonin reduces vascular permeability.

19. Melatonin has been shown to increase ACE2, and this is important because the virus pretty much exhausts or destroys ACE2 as its primary means of virus replication and this is an early point in the infection process that ultimately results in further damage to the cardiovascular system and other parts of the body.

20. Melatonin, through its potent antioxidant and anti-inflammatory qualities, ameliorates the very significant levels of ROS that damage the lungs and contribute to pneumonia. If you can eliminate pneumonia and the cytokine storm, then a ventilator will never be needed. Those three things have shown themselves to be three main things associated with death in Covid-19.

21. Melatonin, through its anticoagulation effects, can reduce thrombosis. Covid-19 is showing the ability to induce thrombosis that can lead to stroke and heart attack in patients with Covid-19. Melatonin's potent antioxidant actions reduce oxidative stress to reduce the potential for thrombosis. Melatonin also reduces edema that can be caused by blood clotting.

22. Melatonin lowers C-Reactive Protein (CRP), which is a marker for inflammation which is elevated in the presence of inflammation and at elevated levels in Covid-19 patients. CRP is a known target in many diseases in which CRP is significantly elevated, including Covid-19. Higher levels of CRP are associated with non-survivors in Wuhan, China.

23. Melatonin lowers Interleukin-6 (IL-6) levels. IL-6 is a cytokine and another inflammatory mediator that is at significantly elevated levels in Covid-19 patients and is known to be a significant contributing factor to the "cytokine storm." Melatonin also inhibits the chemokine IL-8, an upstream inflammatory mediator which draws other inflammatory cytokines and other inflammatory mediators into the fray.

24. Melatonin is useful before, during and after a stroke. This is important because of the increased reporting of strokes and heart attacks caused by Covid-19 disease. Melatonin is heart protective. Melatonin lowers homocysteine and increase nitric oxide. It is good to keep in mind that multiple disease states can diminish native melatonin levels and if you combine that, with the fact that the elderly are already at the very low end of the human melatonin scale, the importance of melatonin starts to become clearer as people with certain pre-existing health conditions are more likely to succumb to the disease and melatonin may help to level the playing field and improve patient outcome and mortality.

25. Melatonin is also available in cream and suppository forms, which may make it an option for patients already on a ventilator. If you are a senior citizen on a ventilator and aware of the survival rate for same, would you want melatonin cream applied or a melatonin suppository or both? Covid-19 increases the cytokine IL-1b which is known to suppress melatonin production. If this is the case, the little melatonin that senior citizen patients have is likely to be depleted even further.

Based on Dr. Neels clinical experience with his Covid-19 patients and their apparent excellent response to his use of high dose melatonin(HDM) in them, all of the above may start to give an idea of what melatonin is doing in those patients to achieve the very beneficial responses Dr. Neel is reporting !

Potential Side Effects of Melatonin

The above is an incomplete list of potential health benefits of melatonin as they might apply to Covid-19 infection in patients.

After going through this list, you may feel that melatonin checks many of the boxes as a molecule to be used against Covid-19, but like anything else, melatonin can have its downsides. Here is a list of known melatonin side effects :

Melatonin use has been associated with drowsiness, alterations in sleep patterns, altered mental status, disorientation, tachycardia, flushing, pruritus, abdominal cramps, headaches, trouble sleeping, bad dreams, and hypothermia.

So this adds further evidence to the idea that your doctor needs to be involved in your decision to use melatonin for Covid-19. Although this side effect list is significant, the drugs currently being tested for Covid-19 are very likely to have more side effects, more severe side effects and adverse events.

Side Effects of two Drugs Currently Being Tested for COVID-19

Here is a link describing the side effects of Remdesivir, one of the drugs currently being tested that is showing modest result against Covid-19 while still allowing a certain percentage of deaths (8 % in the five-day treatment group and 11% in the ten-day treatment group).

heavy.com/news/2020/04/what...

Here is a list of known side effects of Hydroxychloroquine, another popular drug being tested for Covid-19.

rxlist.com/plaquenil-side-e...

Resources and References :

intechopen.com/books/melato...

melatonin-research.net/inde...

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/182...

The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review a... - PubMed - NCBI

ncbi.nlm.nih.gov/pmc/articl...

Effects of melatonin on enzyme activities of glucose-6-phosphate dehydrogenase from human erythrocytes in vitro and from rat erythrocytes in vivo. - PubMed - NCBI

Melatonin and its relation to the immune system and inflammation. - PubMed - NCBI

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

content.sciendo.com/view/jo...

Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release

sciencedirect.com/science/a...

(PDF) Therapeutic effects of melatonin and quercetin on carbon tetrachloride-induced cardiac damage in rats /Sicanlarda karbon tetraklorur ile induklenen kardiyak hasar uzerine melatonin ve quercetin'in tedavi edici etkileri

Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins

journalofdairyscience.org/a...

ncbi.nlm.nih.gov/pubmed/166...

ncbi.nlm.nih.gov/pubmed/166...

hindawi.com/journals/mi/201...

researchgate.net/publicatio...

Interesting about vitamin D amount and the amount of melatonin.

chartist
chartist
in reply to parkie13

Mary,

Yes, it appears to be a balancing act. I think HDM is just a temporary use item, so probably not much of a problem in the short term as far as temporary alteration of that balance!

Art

Here is a link to a brief article about a biomedical scientist who agrees on the use of melatonin for Covid-19 and the latest update on Dr. Neel showing that he is now treating 14 patients successfully with high dose melatonin (HDM) and vitamin C!

devinenews.com/biomed-scien...

tandfonline.com/doi/full/10...

Art

Let's discuss the bad first 😩😩😩 and the good second!

Covid-19 was originally thought to zero in on the lungs and the ACE-2 receptors located there. More recently it has been found that C-19 is attracted to ACE-2 receptors in other areas of the body and the virus is now known to attack much more than the lungs!

C-19 autopsied patients are showing that it is attacking the heart, kidneys, liver, lungs, brain, skin, endothelium and is causing blood clotting which is causing heart attacks and strokes in patients who are otherwise asymptomatic and not considered to be in the high risk groups. Yes, the virus is causing much more damage system wide than initially thought.

C-19 is causing a 4 times increase in Kawasaki disease reports in New York. The disease is attacking the vascular system and causing very elevated oxidative stress levels as well as significantly elevated inflammation. It also seems to be causing significantly more problems in black people who are not necessarily in the at risk groups, but possibly should be.

C-19 is causing heart attacks, strokes, heart damage, pneumonia, liver damage, lung damage, organ failure, Kawasaki or Kawasaki like disease, rash up to full body coverage, blood clotting in different areas of the body that can potentially result in the need for amputation, neuronal damage, intestinal issues and death and this is an incomplete list! Yes, this disease is very serious indeed, even for those not to be considered in the high risk groups. Many of the heart attack and stroke victims are much younger than these two conditions are generally associated with, with no previous symptoms and doctors are only finding out these patients have C-19 when they start working on them and see the damage that is known to be associated with C-19 and that is when they are tested and confirmed to have C-19.

Yes, this is one f'd up disease that is considerably worse than initially thought and it seems like new troubling aspects of this disease are being discovered each week if not almost daily !!!

Now let's discuss the good! 😂😂😂

The good news is that melatonin works against this disease process at multiple levels of disease progression and at every place in the body where the disease has been found because melatonin can readily penetrate body tissues (including its metabolites) and easily cross the BBB to express its very potent antioxidant and antiinflammatory effects as well as other positive effects.

Melatonin is a protector of all major organs and is protective of endothelial cells as well as the skin. Melatonin has anti-clotting abilities. Melatonin has shown itself to "upregulate the gene expression" of some of the bodies own very potent antioxidants such as Catalase(CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) and this aspect of melatonin is very important because it is very likely that all of these natural antioxidant defense mechanisms of the body are being depleted very significantly trying to fight this disease because of the multiple areas of the body being affected simultaneously, so melatonin boosting their production can help to level the playing field giving the body more than a fighting chance to defeat this virus.

Since it has been proven in autopsy that C-19 is attacking multiple areas of the body simultaneously, it is as though the body is fighting multiple diseases all at the same time!Never show up to a gang fight with just yourself! Melatonin's boosting of the body's potent antioxidant system is absolutely needed to deal with something worse than it would normally ever have to deal with in moderate and severe patients. Add to this melatonin's potent and broad antiinflammatory abilities and things are starting to look hopeful!

To add a little more brightness to that light at the end of the tunnel, melatonin itself is a highly potent scavenger of Reactive Oxygen Species (ROS), Reactive Nitrogen Species(RNS), hydroxyl radicals, Hydrogen Peroxide(H2O2) and Peroxynitrite (ONOO). All of these radicals are thought to be highly active in C-19 and doing a lot of damage. One melatonin molecule can scavenge up to 10 oxygen radicals while many other antioxidants can only scavenge and neutralize one oxygen radical 1:1. Melatonin inhibits NADPH Oxidase which is a very bad player that ends up generating ROS in large amounts and damaging almost all cells in its path.

Now let's add in the vitamin C that Dr. Neel is using alongside melatonin in his C-19 patients. Vitamin C is synergistic with the antioxidant and antiinflammatory aspects of melatonin! Together they are better than either one alone and vitamin C pales in comparison to the broad ranging effects that are melatonin, but adding it to melatonin makes melatonin more potent. That light at the end of the tunnel is looking brighter! 💡🔦💡🔦💡🔦💡

A couple of points I would like to make. Originally some people thought that inhalation of food grade hydrogen peroxide via a nebulizer or ultrasonic vaporizer would be sufficient to kill the virus and it likely will in the lungs if you use HP as early as possible, but HP is an oxidant and Catalase will come along and neutralize it soon enough, turning it into water and oxygen, which means HP will not have staying power and more importantly, it suggests that HP will never make it past the lungs to other areas of the body where the virus may be thriving. So I would not want to rely on HP alone.

Though I am a believer and user of silver nanoparticles (AgNPs), although inhaled AgNPs are likely to have staying power in the lungs before being absorbed into the blood I do not believe that by itself it will be enough. It will require drinking the AgNPs also and that combination with melatonin and vitamin C, may just be what it will take to put this virus down as quickly as possible, in my opinion. Although I think melatonin and vitamin C may be sufficient, I think that the addition of AgNPs will speed the process considerably!

Art

chartist
chartist
in reply to chartist

In my post just above this post, I listed many of the known bad health effects of Covid-19 to areas of the body that were previously not thought to be affected by SARS CoV-2 / Covid-19, but this new article suggests that we can add the eyes to this growing list (16 items so far)! As if this disease is not already bad enough!

medpagetoday.com/infectious...

thailandmedical.news/news/c...

Fortunately. small amounts of melatonin are produced in the eyes! Still glad that melatonin may be the answer!

Dr. Neel is up to 14 patients now, all with good response to melatonin!

Art

This new article in Psychology Today discusses Melatonin and Covid-19:

psychologytoday.com/us/blog...

Art

Thailand gets that melatonin may treat Covid-19 too!!!

thailandmedical.news/news/b...

Art

Dr. Neel is currently at 14 patients and according to him, all are doing very well. This is a far cry from what the reports are saying about the drugs that are currently being tested for Covid-19. With any of those drugs, people still die!

It just seems odd that they will not even consider testing melatonin when they already know that none of the current drugs being tested are showing as good results or even just fair results. Melatonin, from hundreds of previous studies has already shown that its multiple methods of action are very likely to have a very significant impact against Covid-19, but the direction seems to remain testing drugs that are not doing much of anything against this virus. In the meantime, people continue to die. Melatonin has a better safety profile than any of the drugs being tested. Melatonin is available over the counter here in the US and production can be ramped up quickly if it proves to work because there are multiple manufacturers already making it. Here is an incomplete list of everything that they currently know Covid-19 can do to humans:

1. Heart attacks

2. Strokes

3. Neuronal damage

4. Liver damage

5. Kidney damage

6. Damage to the spleen

7. Skin damage

8. Heart damage

9. Lung damage

10. Pneumonia

11. Loss of taste and smell

12. Kawasaki or Kawasaki like disease

13. Seizures

14. Death

15. Damage to the eyes

16. Blood clots

17. Damage to the endothelium

18. Oxygen deprivation to tissues and organs

19. Fibrosis

20. Damage to the brain

21. Cytokine storm

22. Covid-19 toes

23. Tissue damage throughout the body

24. Organ failure

25. Fever and oxidative stress

Just about any of the above items would require significant treatment, but with Covid-19, you are almost guaranteed to get at least 5 of these symptoms, which means that it is like your body is fighting multiple diseases all at one time! Melatonin is known through studies to ameliorate symptoms related to this whole list. Furthermore, it is one of the most potent antioxidants in the human body and it upregulates gene expression of the most potent antioxidants of the body and has potent antiinflammatory qualities which are thought to potentially prevent the potential for a cytokine storm.

Given the above, it seems like melatonin would be high on the list for potential drug candidates to treat and test against Covid-19, but such is not the case. I wonder why that is? There is only one study scheduled to use melatonin in Covid-19, but that study is only going to use two milligrams/day. That's not a study, it's a joke and a waste of time and money! Dr. Neel is using 40 times that dose!

Art

Dr. Neel is now at 17 Covid-19 patients as of 5/13/2020, that he has treated with high dose melatonin and vitamin C and all are doing well! The article also mentions that the doctor in Florida who conferred with him has had similar results in her two Covid-19 patients who are both doing well after starting HDM. Here is a link to the article:

devinenews.com/dr-neel-cont...

Art

Here is the latest from Dr. Neel and he is now up to at least 20 patients who are all doing well with rapid response to the combination of high dose melatonin and vitamin C. This latest update sounds very promising and now he reports that patients are now calling him from across the country including New York, Boston and Chicago and they are also doing well with similar results to what he has been reporting!

devinenews.com/dr-neel-sees...

Art

Hi Art. Thanks so much for the info on melatonin.

Here is some information on how melatonin can be used for cancer patients and even as a preventative.


This video also mentions melatonin for Parkinson’s


Russell Reiter has researched melatonin for most of his life

chartist
chartist
in reply to Millbrook

Millbrook,

I often mention that melatonin is one of my favorite supplements and people often look at me funny when I say that because the majority of people only know it as an over the counter sleep aid, but if they knew everything that melatonin can do, they would also call it one of their favorite supplements! In the first video, Dr. Shallenberger mentions a researcher named Pierpaoli who dedicated at least a decade of his life to melatonin research in cancer. I read his studies in the late 90's and that is when I realized that melatonin is so much more than the majority of people realize.

What I like about Dr. Shallenberger is that he pulls no punches when it comes to dosing and this is so very important! The great majority of people would think you were crazy to ever consider such dosing of melatonin, but here he is telling us it is no problem for the majority of people!

Okay, I am just going to blurt it out here, but when you look at all that melatonin does and that does not mean that all is known about what melatonin does in the body, but just based on what is known, melatonin should be an excellent treatment for many neurodegenerative diseases including PD! Melatonin and its metabolites can easily cross the blood brain barrier while also exhibiting the ability to repair it, easily enter body tissues, is one of the most potent antioxidants in the human body, upregulates gene expression of the bodies own potent antioxidants such as Catalase, Superoxide Dismutase and Glutathione Peroxidase while itself being a potent scavenger of Reactive Nitrogen Species, Reactive Oxygen Species/ Hydroxyl Radicals and Peroxynitrite. It is protective of all major organs and that is a critical aspect for Covid-19, but protecting the brain and gut is extremely important in PD and that is what melatonin does!

Melatonin is a potent antiinflammatory and inhibits IL-6, TNF- alpha, IL-8, IL-17, IL-1b and NF- kappa b to name just a few. Melatonin can enter the cerebrospinal fluid(CSF) and if you remember from a post I did about elevated IL-8 in PD patients CSF, that is a very important point about melatonin because reducing IL-8 levels means that other downstream cytokines and inflammatory mediators are also going to be reduced and that is huge!

Melatonin is a mitochondria protector also and again this is very important in PD! There is much more, but the human studies in PD are lacking, so I can't even suggest it to anyone. Listen to what he says about melatonin vs glutathione. PWP are always looking for a way to boost glutathione, especially in the brain, but he knows that melatonin is clearly the superior antioxidant and this is what studies show!!! Sadly, Dr. Shallenberger is the exception and not the rule, but I feel he is doing what should have been done over 30 years ago regarding melatonin!!!

I can only speak for myself and am DEFINITELY NOT RECOMMENDING THAT ANYONE ELSE TRY THIS OR DO WHAT I DO, but if I had PD, I would definitely try melatonin at high dose for 3 months minimum at the type of dosing that Dr. Shallenberger uses for cancer. For me, I don't mind self experimenting, but I would never recommend others try or do what I do!!! He says side effects are minimal to non-existent in his patients and I am currently doing a 1 to 2 month self experiment at 80 mg / day. I already did my initial 3 day experiment at that dose and that went fine as I expected it would because I had previously done a 90 day experiment at 70 mg/day. I am so far not seeing any problems and will continue.

I said it earlier in this thread that any pharmaceutical company would be more than happy to have melatonin as a drug in their catalog and they would make a fortune off of it!

The doctor in the second video, Dr Reitter is well known as a melatonin proponent and also a proponent of the use of melatonin to treat Covid-19!

Thank you for the links!

Art

Millbrook
Millbrook
in reply to chartist

Thank you Art for your detailed reply.

Here is a synopsis of what Dr Shallenberger said in the video that I posted above.

riordanclinic.org/wp-conten...

I baulk at taking 180 mg😬

I shall start at 20 mg and slowly top up. I have just ordered nutricology melatonin but saw on amazon the 60 mg ones. Will keep you posted.

Thanks again Art. You hv been a great help to all of us here

chartist
chartist
in reply to Millbrook

Millbrook,

I watched the videos and I was and am a big melatonin fan and I do not think Dr. Shallenberger covered everything it is likely to help, just some big ones other than cancer, but the studies are steadily pointing out more and more benefits to melatonin in humans with each passing week! I guess you can tell I'm passionate about melatonin by what I wrote to you in my first reply! Just the cancer and Covid-19 benefits are huge and then you add in the other known benefits and it is.....!

Art

Thank you!

Do you think i would derive any benefit from melatonin,i.ve PD for 18 years and feel like it is advancing quicker lately

chartist
chartist
in reply to alanrob

alanrob,

That information is not yet known about melatonin and PD. Many people on this forum have gotten good results with HDT/B-1 if you haven't already tested it. The study that I referenced in the original post to this thread only came out this month, so it is way too early to say how melatonin will work out over time for PWP, but that initial study sounded very promising and they did use a relatively low dose compared to other melatonin studies such as the 300 mg/day study referenced higher up in this thread.

Art

alanrob
alanrob
in reply to chartist

What sort of dose HDT/B-1 is best to start with?

Apparently melatonin and vitamin D may have synergy against Covid-19 lung issues according to this new article :

ncbi.nlm.nih.gov/pmc/articl...

Art

Here is a link to another study suggesting that the known mechanisms of melatonin are likely to be useful against Covid-19. They also include andrographolide derived from andrographis paniculata (well known as an antiviral herb), a very popular and multifaceted herb for its known metabolic activities that are likely to work against Covid-19.

ncbi.nlm.nih.gov/pmc/articl...

Art

Dr. R. Reiter, on the use of melatonin for Covid-19 :

frontiersin.org/articles/10...

Art

Hi again. I have tried to read thru everything on this post but there is so much to read. Since you are so understanding of this, will you give me your opinion on what my dad should start on tomorrow? He doesn't have PD, I do. He's pretty healthy, no high BP, no high cholesterol, etc. I understand you are not a Dr but you seem highly educated and you care.

Thanks, Debbie

chartist
chartist
in reply to laglag

I would say that Dr. Neel has the experience and success with his protocol, so it seems worth considering his protocol because compared to everything else, he has had the best results that I have heard of.

Dr Shallenberger has stated that he feels about 5% of his patients can not tolerate melatonin, so it makes sense to consider an initial low dose for a person to determine if they tolerate melatonin or not. Once it is established that that person can tolerate melatonin, then his protocol seems worth considering.

Another consideration is that he has reported patients and doctors from around the country and world have contacted him to get more information on implementing his protocol and maybe this is something you might consider. It seems pretty straightforward, but as far as I know, he has not mentioned the vitamin C dose he is using with melatonin, just that he has used it. I think it is worth considering the addition of vitamin D since melatonin and vitamin D have recently shown synergy against Covid-19.

Art

FYI....As you can see from the post earlier , my dad tested positive for covid-19 but he's asymptomatic.

The study link below suggests that melatonin also reduces the risk of testing positive for Covid-19!

What will it take for mainstream medicine to consider melatonin as a potential drug candidate for Covid-19? In very limited testing has so far shown itself to be superior to Remedesivir, Hydroxychloroquine, Ritonavir, Favipiravir, Lopinavir and many more.

pubmed.ncbi.nlm.nih.gov/325...

Art

This new article explains how melatonin inhibits the cytokine storm seen in some Covid-19 patients.

sciencedirect.com/science/a...

Art

GREAT NEWS!!!

Dr. Neel's latest report shows that he now has 50 patients who have recovered from Covid-19!!! Best report yet with more details!

devinenews.com/50-covid-pat...

It turns out the hospital in Manila had 10 patients treated with HDM who recovered and now they are funding a trial of 350 patients who they will treat with melatonin, but this time they are only going to take patients who have Covid-19 and pneumonia! Pretty confident on their part to take on 350 of what are some of the worst cases!

Dr. Neel has also clarified the dosing for other doctors who want to use HDM for their Covid-19 patients. It is 1 mg per kilogram, that's it! He no longer makes mention of the use of Vitamin C.

Art

ConnieD
ConnieD
in reply to chartist

Excuse my ignorance Art but is that just 1mg Per day or do you mean based on an individuals weight? Thank you 😊

chartist
chartist
in reply to ConnieD

Connie,

The dose that Dr. Neel has determined as effective for his Covid-19 patients is one (1) mg of melatonin per kilogram that the patient weighs. Here is a converter to convert kilograms to pounds or pounds to kilograms :

google.com/search?q=convert...

Just enter the number that you are in pounds or kilograms and it will show the correct kilogram or pound equivalence.

Art

ConnieD
ConnieD
in reply to chartist

Thank you so much Art, This is such hopeful information, Thank you for your research!

chartist
chartist
in reply to ConnieD

You're welcome, Connie!

When you combine Dr. Neels 50 patient melatonin recovery experience with what the Philippine hospital in Manila has reported about the 10 patients they used melatonin on along with their new trial to treat 350 more covid-19 patients who have pneumonia, it is very hopeful! I have not seen anything comparable to what Dr. Neel is reporting in other trials.

I haven't seen any other trial where the researchers have said they only want to treat Covid-19 patients who also have pneumonia. That is a huge challenge to try and take on because Covid-19 patients with pneumonia have a significantly higher chance of dying than non pneumonia Covid-19 patients. With Covid-19 pneumonia, it is probable that the patient had Acute Respiratory Distress Syndrome (ARDS) leading up to the pneumonia. Currently it appears that patients who got ARDS had a 50% higher death rate than those who didn't! Doctors Hospital of Manila may have their work cut out for them.

statnews.com/2020/03/03/who...

Art

So glad you found and shared this hopeful information, it will be interesting to see how the patients with pneumonia do once treated with melatonin. I will definitely be watching for any new information! Thank you again Art!

Here is the latest update from Dr. Neel. It appears that he now has 100 patients which makes sense since Texas is one of the states that are getting cases at an increased rate. He also reiterates about the synergy between melatonin and vitamin D. His patients continue to respond very well to HDM and he has had no deaths. Here is a link to his update :

devinenews.com/cases-come-b...

Here is a new report by a nurse who was treated by Dr. Neel for Covid-19 and what her experience was like :

devinenews.com/medina-count...

Art

Here is a link to a new abstract suggesting that melatonin may be useful for restoring the glutathione redox system as well as for Covid-19 :

pubmed.ncbi.nlm.nih.gov/325...

Art

parkie13
parkie13
in reply to chartist

Hi Art , did you see, perhaps in another article the dosages?

chartist
chartist
in reply to parkie13

It appears they were using a high dose at approximately 2.85 mg per kg. So if you weighed 70 kg it would be about 200 mg.

Art

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