Another Potential Benefit Of Melatonin for PwP

[chartist]

People with PD have a higher prevalence of cataracts compared to the general older population as discussed in the following link :

ajmc.com/view/cataract-surg...

Here is a relevant quote from the article :

' Patients with PD additionally have higher prevalence of cataract compared with the general older population, which if left untreated can result in poor vision and vision loss. '

This new study ( May 2023) suggests that melatonin may be a useful supplement in helping to delay cataract progression based on an AI review of the literature that created a list of the top 10 drugs that showed potential in inhibiting cataract formation and progression :

pubmed.ncbi.nlm.nih.gov/372...

Here is a relevant quote from the study :

' The suppressive effects of aspirin, acetylcysteine, and ibuprofen waned over time, while those of melatonin became stronger in both genders. Thus, the four repositioned drugs have the potential to delay cataract progression in both genders. All four drugs share the ability to directly or indirectly inhibit cyclooxygenase-2 (COX-2), an enzyme that is increased by multiple cataractogenic stimuli. '

Art

[Gigi216]

I’ll have to mention that to my daughter, she developed cataracts at age 5. She had surgery at 15 and she’s 34 now. She has been noticing more glare at night lately. Always nice to find things that can be helpful, thanks

[chartist in reply to Gigi216]

How is she doing with the P?

Art

[Gigi216 in reply to chartist]

She is doing great! She’s very happy with the progress. She did the diet for several months you suggested and saw major improvements. She’s not following it now but it hasn’t returned so far, thanks for the info and if it does worsen I’m sure she will follow it again

[chartist in reply to Gigi216]

Very good to hear and I am very happy for her!

Art

[gomelgo]

what's the diet?

[chartist in reply to gomelgo]

It wasn't actually a diet, but rather a slight change to the way you look at eating. I had suggested rather than just saying you are going to go on a strict diet which can be overwhelming for many people once they realize they won't be able to eat many or most of the things they like to eat, rather to look at each food item as they are considering consuming it and deciding right then whether they want to eat it or not, knowing the consequences in terms of weight gain. In this way you can still eat what you want, but make an immediate decision right at the time of consumption instead of saying that I can never eat something like ice cream again. It doesn't work for everyone, but it does for some people.

Art

[gomelgo in reply to chartist]

I love that mind habit! Thanks for sharing.

[LindaP50]

Hubby with PD age 83 1/2 doesn't have cataracts. Me at 71 have the start of cataracts. HWPD was diagnosed with macular degeneration. Will have to research to see if any positive benefits with Melatonin for macular degeneration.

[chartist in reply to LindaP50]

Yes, melatonin does offer benefit for age related macular degeneration.

Art

[LindaP50 in reply to chartist]

Thanks. By the way, I keep saying hubby is 83 1/2 but he's 84 1/2. Already revised one of my posts!!!

[opera1968 in reply to chartist]

What is the dose of Melatonin for Age related Macular Degeneration?

[chartist in reply to opera1968]

Studies have shown that as little as 3 mg/night are helpful for AMD.

Art

[opera1968]

Art, Thank you,

Andy

[chartist in reply to opera1968]

You're welcome Andy.

ncbi.nlm.nih.gov/pmc/articl...

A relevant quote :

' These results indicate that melatonin attenuated NaIO3-induced mitophagy of ARPE-19 cells via reduction in ROS-mediated HIF-1α targeted BNIP3/LC3B signaling in vitro and in vivo. Melatonin may be a potential therapeutic drug in the treatment of AMD. '

sciencedirect.com/science/a...

A relevant study quote :

' Our findings suggest that MT can effectively ameliorate retinal degeneration and regulate immune homeostasis via Tregs. Modulation of the immune response may provide a key therapeutic strategy. '

Melatonin has a very good safety profile. I take 132 mg+ per night as a preventative against a multitude of health issues such as AMD.

Art

[opera1968]

Art, Thank you for sharing your experience and knowledge of Melatonin. I am considering taking it too.

Andy

[chartist in reply to opera1968]

opera1968,

Good luck and keep us posted on how you do with it!

Art

[LindaP50]

Hubby and I both took Melatonin 10 mg. Results 10mg too high. Hubby took Melatonin an hour before going to bed and had difficultly walking. Same with taking 30 minutes before bed. Local store only has 10mg or 5mg. Searched online and there is a 2mg which we will both try because there are so many benefits.

[chartist in reply to LindaP50]

There are also .3 mg available online as some people get improved sleep with that very low dose :

amazon.com/Carlyle-Melatoni...

Art