Fat-soluble B1, for a 25x enhancement at the brain ?

[Pa-zzi69]

My question to you and to a neurologist who supports Dr Costantini’s Thiamine B1 protocol:

Given the information below, I am curious to know your opinion about a switch from water-soluble Thiamine B1 to a fat-soluble B1, for a much enhanced [25 times] efficiency at the brain…

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An interesting 16min. video on the importance of vitamin B1 to a surprising number of bodily functions, and the diseases caused by lack of it.

youtube.com/watch?v=rjVXFqi...(Not working as expected?)

Table of content of Dr Berg’s video:

- min 0-10: the importance of B1 to many organic functions and diseases caused by lack of it.

- min 10-14 : B1-deficiency factors,

- min 14-15 : 13 nutritional sources of B1 including these new to me: nutritional yeast, unfortified; pork;

Note: avoid excess coffee, tea [Is decafeinated harmless ?]

- min 15-16: B1 synthetic supplement, fat-soluble 25 times more efficient than water-soluble:

BENFOTIAMINE to be taken with nutritional yeast, unfortified, particularly recommended for nerve issues, as in Parkinson. Fat-soluble, it impacts the brain 25 times more than water soluble B1, such as Thiamine HCL. This is confirmed in the 2008 Scientific opinion by the European Food Safety Authority which recommends a maximum intake of 100 mg/day [10-to-20 times less than Dr Costantini’s Parkinson protocol], reports no adverse effect at 400mg, yet does not commit on safety based on insufficient data...

Note: Strangely, while a photo of a bottle of L-Tyrosine Caps, 500mg appears on the video, Dr Berg speaks instead of Benfotiamine.

Note: A commercial presentation of L-Tyrosine by Country Life makes no mention of vitamin B1: « L-Tyrosine is an amino acid that supports the production of brain neurotransmitters dopamine and norepinephrine. Country Life uses vitamin B6 in order to aid in utilization.» [whatever utilization means… maybe absorption ?]

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[Gioc]

Here a research by L. Bettendorff that he is one of the greatest researchers of B1 in all its forms. You could find the answer to the "conclusions" chapter.

Definition:”sulbutiamine, a lipid-soluble thiamine disulfide derivative.”

It is different of Benfothiamine.

ncbi.nlm.nih.gov/pmc/articl...

[Pa-zzi69 in reply to Gioc]

Thank you ! I'll try to digest this scientific paper...

[Gioc in reply to Pa-zzi69]

It is a series of research on mice that in the conclusion chapter says that benfothiamines are good for the body but do not reach the brain ... in mice. Then there is also the "lipid-soluble thiamine disulfide derivatives" that are another series of liposoluble vitamins derived from garlic that go a little better. But it is my opinion that the old, good genuine HCL hydrosoluble thiamina is the safest. This is an imprecise simplification of what I understood.

[Pa-zzi69 in reply to Gioc]

Thank you again for your helpful clarification !

[LAJ12345]

I wonder if part of the effect of thiamine HCl is that the HCl helps acidify the stomach to aid digestion. As well as the thiamine effect.

[MarionP in reply to LAJ12345]

No, that is incorrect. The acid your stomach produces is the closest thing in quantity and pH to battery acid that you will encounter outside an auto parts store.

[MarionP]

I sure wouldn't do it. Could easily become toxic at low quantities built up in your adipose tissue. The thing about water soluble is that whatever your system uses, the excess is drained right back out of you. There could be significant negative effects of not being able to flush out overdoses. Do some more homework and research on that and report back.

[Pa-zzi69 in reply to MarionP]

Thank you ! I'll heed your warning. It makes intuitive sense, yet I'm curious to understand what you base it on, other than intuition plus common sense. Could it be that you have an appropriate scientific background ? Thank you again for your eye-opening response ! MarcP

[genesurf]

I don't have PD but I have some experience with fat-soluble thiamine. At one point I was taking six capsules (50mg each) of Allithiamine per day, and had no side effects.

It worked well to reduce my paresthesia and fatigue before I discovered B12 injections. Currently I take one Allithiamine per day.