Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease

[Farooqji]

nature.com/articles/s41467-...

[park_bear]

The title of this paper is not very informative, but they came up with an interesting result. They found that bacteria in the gut can convert levodopa into dopamine even in the presence of carbidopa. That explains why I get nauseous with enough Sinemet.

[Fed1000]

It is becoming increasingly likely that the intestinal microbiota interferes with the efficacy of drug treatment.

[reedboat2]

Interesting article. In light of this research are there specific ways to influence the microbiome to become more treatment friendly?

[Gioc]

very interesting. This could open the way to a more appropriate and less intense use of levodopa, which is what we would need at any stage of the disease.

[Hidden]

This doesn't sound good for PWPs and the general population if you are taking omeprazole or other PPIs! I wonder if a L/C patch is a work around for this problem or are we back to fecal microbiome transplants as one way forward and around this problem?

Art

[Hidden]

I've been thinking about this bacterial gut issue discussed by the study and the thing that keeps coming to mind, aside from the PPI problem which is a real and proven problem already, is that Dr. C has always maintained that patients who start on HDT and are stable at their optimum dose and with a good push test, will never need to increase their levodopa dose and in some cases are able to actually reduce their levodopa dose and so far that positive effect has also been mentioned by some forum members who have incorporated HDT into their treatment regimen. Since Dr. C seems to be correct on this point, then possibly thiamine / HDT / B-1 may be affecting a microbiome change that may be nullifying or negating the bacterial alteration described by this study! Another point worth considering is that none of the HDT testers on this forum have reported having to deal with SIBO, yet in the study, SIBO seems to be heavily associated with the bacterial change that they studied! Apparently this could potentially be one or two of the methods of action that HDT utilizes to do what it does for some PWPs.

Art

[Dehlia in reply to Hidden]

What is HDT?

[bibsie in reply to Dehlia]

High dose thiamine (B1 HCl)

[Hidden]

Based on my post above I found this study which suggests that thiamine can and does have wide ranging effects on the gut microbiome which we have discussed before.

ncbi.nlm.nih.gov/pmc/articl...

Perhaps thiamine does have a nullifying effect on the bacterial process described in the study and possibly why HDT users do not have the problem with the need for increasing levodopa / mucuna dosing over time!

Art

[Dehlia in reply to Hidden]

Thanks for assurance

[Dehlia]

that abundance of bacterial tyrosine decarboxylase in the proximal small intestine can explain the increased dosage regimen of levodopa treatment in Parkinson’s disease patients

Any suggestions on how one with PD can safely minimize this bacteria?

[Gioc in reply to Dehlia]

Good question

[Hidden in reply to Dehlia]

Apparently, HDT does this.

Art

[billiards]

From, Billiards.

To,

Community parkinson’s

The following materials came across through the “whats’up” and i am conveying the same as appeared: if anyone has come across and found it useful please inform

Pakistani Student invents a technology to cure paralysis disease

Neha Chaudhary is Pakistani student at University of West England

She develops a STICK to cure Parkinson’s disease : this disease affect nerve system of Brain

Which cause disability in movement of muscles. Until now this disease has no proper treatment and all depends on patients WILL POWER to be able. Neha invented this stick when her father got paralyzed . neha said, she started work on it in 2014. As her university’s final project. This stick has been tested on a lot of people in England. National Health Services England showed interest on her project . for this Neha started her own company named “Walk to Beat “. Stick is made of plastic light weight to carry and have High-tech sensors and help patients to move their limbs . smart sticks are available for trial. Share this video to them