My friend was diagnosed nearly 3 years ago and has been doing well until recently. She takes Sinemet 25/100mg four times a day along with 1 x Mirapex. She`s having more problems during her off time between Sinemet doses and has started to freeze on occasions which has caused her great concern. This has only occurred the last 2 or 3 months, does anyone know if this is typical or should she be looking at getting her medicine tweaked or maybe changed? would Sinemet SR be of any help? She has never got any known benefit from the Mirapex since she has been on it (18 months) Any feedback would be great.