Methotrexate side affect

[arvine]

I did my 4th weeklybinjection of 20 mgs of methotrxexate yesterday morning, yesterday afternoon and all day today felt worse than ever, severe body pain, jpints and muscles,spent all daybon couch hurting and verybtired , thought this was at least not increase pain, seriously thinking of stopping, anyone out there had similar experience?

[Jadamski]

Sorry you’re not feeling great!

I’ve been on Metoject for over 12 years and it’s fine but early days I think it took a while to settle down. I tend to inject before I go to bed so I’m asleep and not aware of what’s happening . Perhaps give that a try?

[Marylyn]

sorry but I can not recommend methotrexate.Your Drs are not telling you it depletes folate & vit B12 which is essential for nerve & blood maintenance .I saw my next door neighbour deteriorate waste away taking it & folic acid .She told her Dr I saved her life by ceasing her meds She took vit b12 sublingual , methyl folate in an active vit BComplex She is alive & well still supplementing with vit b supplements. .

[arvine in reply to Marylyn]

Thank you, I was hesitant to take it, but grasping at straws, and so looking fwd to continuing prednisone taper, as I feel afrer 8 yrs has contributed to a lot of other health issues in the last year, Ivebonly taken 4’injections in last 4 weeks, with no pain relief yet of course, but seriously considering stopping before any of the several possible side affects happen to me,

[Marylyn]

Can I ask why you are taking all these heavy meds ? I believe you are experiencing inflammatory nerve pain from nutritional deficiencies eg vit D ,Vit B12 ,magnesium,calcuim,zinc,vit C .I haven’t met anyone yet that has received good pain relief from drugs or injections of ,cortisone,Lyrica,Neurontin,Gabapentin.50 yrs ago I had injected into my spine x3 caudal blocks cortisone for supposively sciatica .Now my all my spine has degenerated especially lumbar .I have scoliosis,spondylosis & severe cervix& multi level spinal stenosis I take only vitamins & minerals bi weekly b12 injections to repair nerve damage .I have Pernicious Anaemia.

[arvine in reply to Marylyn]

Yesvwelln8!yrs ago was diagnosed with polymyalgia rheumatica, had never heard of ot, it s autoimune disease, pit on 40 mgs of prednisone, gradually tapered to 4 mgs until Dec 2022 had GCA symptons, so rheumy put me back to 40 gs, as you can lose your eyesight if not treated, had tests done , result negative, only showed subacute stroke, anyway started tapering again, but slow process , ot of stressful events especially July 2022 lost son to cancer, leukemia, been fighting since 2018, anyway ast year and onward health problems, MRI s exrsys etc detetmined osteoarthritis, back, hip hands, since June of this year been in chronic pain, hard to taper prednisone but did get down to 4 mgs by april of this year, so now as said rheumy said only med may help is methotrexate, that s why I started on it, I take calcium and vit d3, and that is why Im on prednisone and methotrexate,