Onset Delay with Percocet/OxyContin - Pain Concern

Pain Concern

39,059 members12,025 posts

Onset Delay with Percocet/OxyContin

RBeard86 profile image
6 Replies

I've been taking Percocet and OxyContin for about a year now. I've noticed in the past couple of weeks that these medications take longer than normal to kick in; sometimes almost three hours.

This is all independent of my tolerance for the medication; I've seen the research and charts that indicate that both of these medications should reach therapeutics levels in the bloodstream 45-60min after administration, but I've noticed feeling no relief at all (and sometimes wondering if I took the wrong pill, or imagined it entirely), before it finally kicks in.

Has anyone else experienced this? Or does anybody know what may be causing this delay?

Written by
RBeard86 profile image
RBeard86
To view profiles and participate in discussions please or .
Read more about...
6 Replies
Candycane308308 profile image
Candycane308308

I am also on Percocet/OxyContin and it's been over five years the more pain I'm in the less the medicine works. The more active I am less my medicine works. Sorry I'm still not sure why.

johnsmith profile image
johnsmith in reply toCandycane308308

This is to be expected. Pain killers desensitise the body to further damage of the damaged part. So over a period of time the greater damage requires greater amount of pain killer to quieten the complaining damaged tissue.

Internal injury creates scar tissue of sorts. The area around the injury gets bruised with physical activity. Tissue inflames and hurts more.

This theory is different from the standard nerve damaged theory which sells pain killers.

Madlegs1 profile image
Madlegs1

Not fully sure of my facts- but is there a link between food intake and med efficacy? Something about high fat meal affecting the processing of medicine.

Might be worth googling that topic.

littlefloyd profile image
littlefloyd in reply toMadlegs1

A fatty meal slows absorption; an empty stomach should cause the mess to kick in - in 1/2 hour

littlefloyd profile image
littlefloyd

😎I mean - medicine to kick in😎

Madlegs1 profile image
Madlegs1 in reply tolittlefloyd

Nah! Your first answer was correct!!!😂

Thanks for the info- I was too lazy to check it out.

Cheers.

Not what you're looking for?

You may also like...

Oxycontin not lasting.?

I've been on oxycontin for lower back pain ( and also helping with restless legs) for six months....
Madlegs1 profile image

Oxycontin refusal

I'm not going to start with formalities, this is about the 50th place I have come to find help,...

Oxycontin failure

Hi all- just wondering if anyone on opiates has experienced this phenomenon? I take oxy 10 twice a...
Madlegs1 profile image

Oxycontin

Seem to have heard a little too much about this drug in the last few days but here goes.... Pain...
Bananas5 profile image

Oxycontin

David was put on Oxycontin 70mgs about 9 months ago with a 'spare' 10 extra if he needed. Oxynorm...
Bananas5 profile image

Moderation team

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.