Hello ladies! I was wondering if anyone else has had really high liver enzyme levels?
I was diagnosed with HGSOC 3c in December 23, started chemo (paclitaxel , carboplatin & Bevacizumab) in Jan 24. Debulking surgery April 24. Two more chemo cycles post op, (NED) then onto Bev as maintenance, which I’m due to finish in July. I’ve had stubbornly high liver enzyme readings, which they previously put down to the chemo, and while they’ve come down, they remain high even though Bev (Avastin) is not supposed to affect the liver. (Last week ALT had come down to 85 but ALP had gone up to 411. I had an ultrasound last week which showed I have fatty liver disease! I’m not overweight (BMI 23), don’t smoke, don’t drink, eat extremely healthily and exercise (moderately, mostly walking) every day. The doctors are puzzled.
Anyone had similar? They keep postponing my treatment because of it.
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DevonPaddleboarder
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I was diagnosed 3b HGS in 2007, given 2 years. Treated with carbo/taxol alongside trialling Avastin. I was told I had a fatty liver. That was mentioned twice. Despite 2 recurrences, 2 further clinical trials, still here 11.5 years NED. Fatty Liver didn’t seem an issue.
Hi Katmal, thank you for your reply. I just read your bio and you’ve given me so much hope for the future, when half of this battle with this disease is with your own mind, of what the future holds etc. Hopefully lots of good stuff for a long time!🤞 🤞 🤞Life is what goes on while you’re busy doing other things, or something like that. I try to enjoy every single day now as it definitely changes your perspective on life!
And really good to hear you’ve had no issues from the fatty liver; do you know if it’s cleared up or if you still have it?
I have no symptoms but worried they’re going to stop my treatment altogether because of it, or that it is caused by something more sinister.
To be honest It’s not been mentioned again. Given I’m overweight I assumed I still have it. It never stopped me having chemo for my 2 recurrences or taking part in 3 clinical trials. I’m still on my third clinical trial/study and I do get my liver checked (via blood tests) every 12 weeks and it seems to be working fine. My mindset is ‘I was told my prognosis is poor, I went back to work full time as soon as I could, no phased return etc and got on with life, nobody is guaranteed tomorrow and nobody gets out of life alive so I kept going. Now in my 18th year and living life. I feel so well and I’ll deal with tomorrow when it happens.’ I dare say there’s lots of ladies out there doing the same. Good luck xx
That’s the way to go Kathy! Just get on with life, try & fill it with joy and things that matter. Keep busy. I’m learning to do that gradually. I do have the occasional wobble but you’re right, no one lives forever but some people live to 100 but have done very little.
I’m putting my faith in better and better treatments that will hopefully keep me going for a long while yet. Well done for taking part in the trials. You’re certainly an inspiration. Xx
My liver enzymes have been slightly elevated since I started taking zejula about 3 years ago. Even though I haven’t taken it for two years, my ast and alt are consistently slightly elevated. None of my doctors have ever shown any concern about it, and it never interfered with my treatment. I am not overweight, but I do drink occasionally which my doctors know and aren’t concerned about; they of course discourage regular/heavy drinking. Ihave been NED for 2 years.
Glad it’s not been an issue for you. I’m hoping mine will normalise a bit more once I finish the maintenance treatment this summer (fingers crossed 🤞 I can!)
I had a few drinks over new year but only a couple of glasses of wine since then and nothing in the last month, so I don’t think it can be alcohol related. Will completely stay off the booze from now on though.
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To chemo or not to chemo?
Stage 4 no more treatment options 
CA125 increased during Chemo 
Chemo delayed again as I’m 0.7 neutrapenic
