High ALT, ALP & GGT & fatty liver!

[DevonPaddleboarder]

Hello ladies! I was wondering if anyone else has had really high liver enzyme levels?

I was diagnosed with HGSOC 3c in December 23, started chemo (paclitaxel , carboplatin & Bevacizumab) in Jan 24. Debulking surgery April 24. Two more chemo cycles post op, (NED) then onto Bev as maintenance, which I’m due to finish in July. I’ve had stubbornly high liver enzyme readings, which they previously put down to the chemo, and while they’ve come down, they remain high even though Bev (Avastin) is not supposed to affect the liver. (Last week ALT had come down to 85 but ALP had gone up to 411. I had an ultrasound last week which showed I have fatty liver disease! I’m not overweight (BMI 23), don’t smoke, don’t drink, eat extremely healthily and exercise (moderately, mostly walking) every day. The doctors are puzzled.

Anyone had similar? They keep postponing my treatment because of it.

[Katmal-UK]

I was diagnosed 3b HGS in 2007, given 2 years. Treated with carbo/taxol alongside trialling Avastin. I was told I had a fatty liver. That was mentioned twice. Despite 2 recurrences, 2 further clinical trials, still here 11.5 years NED. Fatty Liver didn’t seem an issue.

[DevonPaddleboarder in reply to Katmal-UK]

Hi Katmal, thank you for your reply. I just read your bio and you’ve given me so much hope for the future, when half of this battle with this disease is with your own mind, of what the future holds etc. Hopefully lots of good stuff for a long time!🤞 🤞 🤞Life is what goes on while you’re busy doing other things, or something like that. I try to enjoy every single day now as it definitely changes your perspective on life!

And really good to hear you’ve had no issues from the fatty liver; do you know if it’s cleared up or if you still have it?

I have no symptoms but worried they’re going to stop my treatment altogether because of it, or that it is caused by something more sinister.

Anyway; wonderful to hear some good outcomes. 🤗

[Katmal-UK in reply to DevonPaddleboarder]

To be honest It’s not been mentioned again. Given I’m overweight I assumed I still have it. It never stopped me having chemo for my 2 recurrences or taking part in 3 clinical trials. I’m still on my third clinical trial/study and I do get my liver checked (via blood tests) every 12 weeks and it seems to be working fine. My mindset is ‘I was told my prognosis is poor, I went back to work full time as soon as I could, no phased return etc and got on with life, nobody is guaranteed tomorrow and nobody gets out of life alive so I kept going. Now in my 18th year and living life. I feel so well and I’ll deal with tomorrow when it happens.’ I dare say there’s lots of ladies out there doing the same. Good luck xx

[SuffolkJen in reply to Katmal-UK]

You are such an inspiration Katmal-UK xxJen

[DevonPaddleboarder in reply to Katmal-UK]

That’s the way to go Kathy! Just get on with life, try & fill it with joy and things that matter. Keep busy. I’m learning to do that gradually. I do have the occasional wobble but you’re right, no one lives forever but some people live to 100 but have done very little.

I’m putting my faith in better and better treatments that will hopefully keep me going for a long while yet. Well done for taking part in the trials. You’re certainly an inspiration. Xx

[thejoannabell]

My liver enzymes have been slightly elevated since I started taking zejula about 3 years ago. Even though I haven’t taken it for two years, my ast and alt are consistently slightly elevated. None of my doctors have ever shown any concern about it, and it never interfered with my treatment. I am not overweight, but I do drink occasionally which my doctors know and aren’t concerned about; they of course discourage regular/heavy drinking. Ihave been NED for 2 years.

[DevonPaddleboarder in reply to thejoannabell]

Glad it’s not been an issue for you. I’m hoping mine will normalise a bit more once I finish the maintenance treatment this summer (fingers crossed 🤞 I can!)

I had a few drinks over new year but only a couple of glasses of wine since then and nothing in the last month, so I don’t think it can be alcohol related. Will completely stay off the booze from now on though.

Xx

[Katmal-UK]

Thank Jen. Wishing you well xx Kathy

[Barlow1951]

Hello,

I’ve had elevated ALP levels since chemo in February 2016 and have been under a liver consultant since 2019. My levels have varied between 200 plus and 400 plus and I am on 4 tablets daily. I was also told last time that I had a fatty liver, first time this has been mentioned. I have never been told that this is anything to be concerned about but they just monitor me every few months. I reckon it must be a rare side effect from chemo but have no symptoms and don’t let it concern me. Hope that helps put your mind at rest.

[DevonPaddleboarder in reply to Barlow1951]

Hi, glad to hear it’s not caused you any issues. My ALP was 800 at worst but quite high even before I started the chemo and did go down after I started the treatment. I’ve now on Avastin maintenance, and the ALP seemed stuck around 200-300 but my last reading was over 400. So i’m not sure it’s the chemo… 🤔 they’re doing further tests…

[DevonPaddleboarder in reply to Barlow1951]

I meant to ask what the tablets are you are taking?

[Barlow1951]

I am taking Ursodeoxycholic acid 250 mg capsules- 4 to be taken each day, but I can’t say I’ve noticed any changes. The blood readings continue to fluctuate between 200 plus and 400 plus for no identifiable reason, but as the liver causes me no problems, I largely ignore it, until I have my regular monitoring appointment. Hope that will reassure you..

[LornaNZ]

Hi Devon is your GGT liver enzyme elevated too? My ALT and GGT liver is elevated too. Im on 9 months post chemo.

[DevonPaddleboarder in reply to LornaNZ]

Hi Lorna, yes my GGT is currently 517! (ALP 411, ALT 83) Are you still on a maintenance treatment? I’m 8 months past chemo but still on Bev.

[LornaNZ in reply to DevonPaddleboarder]

No after my chemo last June 2024 I dont have any maintenance at all but for some reasons my GGT was 146 and ALT was 100.Still elevated after 9 months of chemo,hopefully its not a recurrence to the liver.Thank you.